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Paper · 19951971

Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia.

Park S and 9 others. Haematologica, 2010. Cited by 257 papers, by iCite.

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ConductScience Library. Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia. Papers, record 19951971. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/19951971

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia.
PubMed
Journal
Haematologica
PubMed
Year
2010
PubMed
Publication types
Journal Article, Review
PubMed
Citations, by iCite
257
iCite
Relative citation ratio, by iCite
5.97
iCite
Revised in PubMed
2026-01-28
PubMed

Authors10

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Park SSophie
2Chapuis NNicolas
3Tamburini JJérôme
4Bardet VValérie
5Cornillet-Lefebvre PPascale
6Willems LLise
7Green AAlexa
8Mayeux PPatrick
9Lacombe CCatherine
10Bouscary DDidier

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Leukemia, Myeloid, AcuteMajor topic
Phosphatidylinositol 3-KinasesMajor topic
Proto-Oncogene Proteins c-aktMajor topic
Signal TransductionMajor topic
TOR Serine-Threonine KinasesMajor topic
Animals
Antineoplastic Agents
Class I Phosphatidylinositol 3-Kinases
Drug Delivery Systems
Humans

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References115

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
118,697,750Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit.J Biol Chem2008https://conductscience.org/library/papers/18697750PubMed
217,502,453Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells.Blood2007https://conductscience.org/library/papers/17502453PubMed
39,778,245Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.Cell1998https://conductscience.org/library/papers/9778245PubMed
416,702,948A selective inhibitor of the p110delta isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16.Oncogene2006https://conductscience.org/library/papers/16702948PubMed
512,529,653Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia.Leukemia2003https://conductscience.org/library/papers/12529653PubMed
615,183,893Vascular endothelial growth factor receptor-1 and receptor-2 initiate a phosphatidylinositide 3-kinase-dependent clonogenic response in acute myeloid leukemia cells.Exp Hematol2004https://conductscience.org/library/papers/15183893PubMed
716,236,521The molecular pathogenesis of acute myeloid leukemia.Crit Rev Oncol Hematol2005https://conductscience.org/library/papers/16236521PubMed
819,049,823The c-Kit/D816V mutation eliminates the differences in signal transduction and biological responses between two isoforms of c-Kit.Cell Signal2009https://conductscience.org/library/papers/19049823PubMed
918,337,767Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.Leukemia2008https://conductscience.org/library/papers/18337767PubMed
1019,644,473Targeting the phosphoinositide 3-kinase pathway in cancer.Nat Rev Drug Discov2009https://conductscience.org/library/papers/19644473PubMed

1 to 10 of 115

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Cited by162

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 257 citations.

PMIDTitleJournalYearIn PapersSource
42,634,207Emetine and Its Derivatives as Anticancer Agents Targeting the PI3K/AKT/mTOR Pathway: A Narrative Review of Mechanisms, Pharmacology, and Clinical Insights.J Cell Mol Med2026https://conductscience.org/library/papers/42634207PubMed
42,466,468FLT3 inhibitors in AML: from classic scaffolds to next-generation approaches.RSC Adv2026https://conductscience.org/library/papers/42466468PubMed
41,884,472Deciphering Multitarget Mechanisms of Cardiac Glycosides in Acute Myeloid Leukemia Using a Network Pharmacology and Molecular Docking.Drug Des Devel Ther2026https://conductscience.org/library/papers/41884472PubMed
41,827,900Cytokines, Signaling and Epigenetic Mechanisms: Shaping the Acute Lymphoblastic Leukemia Microenvironment.Cells2026https://conductscience.org/library/papers/41827900PubMed
41,595,108Implementation of Natural Products and Derivatives in Acute Myeloid Leukemia Management: Current Treatments, Clinical Trials and Future Directions.Cancers (Basel)2026https://conductscience.org/library/papers/41595108PubMed
41,544,107DC-STAMP activates the PI3K/AKT/mTOR signaling pathway to regulate PANoptosis in acute myeloid leukemia.PLoS One2026https://conductscience.org/library/papers/41544107PubMed
41,182,553Unveiling the role of microRNAs, the PI3K/AKT pathway, and their associations in various types of leukemia: a comprehensive review.Blood Res2025https://conductscience.org/library/papers/41182553PubMed
41,164,126Integrated machine learning-based establishment of a prognostic model in multicenter cohorts for acute myeloid leukemia.Front Oncol2025https://conductscience.org/library/papers/41164126PubMed
41,104,252Expression Modulation of Immune Inhibitory Molecules by Small Molecule Inhibitor Drugs in Leukemic Cells of Chronic Lymphocytic Leukemia.Iran J Pharm Res2025https://conductscience.org/library/papers/41104252PubMed
41,080,716Bioinformatics differential expression analysis of the effect of cannabidiol in chronic myeloid leukaemia cell line.Glob Med Genet2025https://conductscience.org/library/papers/41080716PubMed

1 to 10 of 162

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Genes6

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
AKT1207PubTator's text mininghttps://conductscience.org/library/genes/207NCBI Gene
IGF13,479PubTator's text mininghttps://conductscience.org/library/genes/3479NCBI Gene
IGF1R3,480PubTator's text mininghttps://conductscience.org/library/genes/3480NCBI Gene
IRS28,660PubTator's text mininghttps://conductscience.org/library/genes/8660NCBI Gene
MTOR2,475PubTator's text mininghttps://conductscience.org/library/genes/2475NCBI Gene
PIK3CD5,293PubTator's text mininghttps://conductscience.org/library/genes/5293NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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