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Paper · 21397859

The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma.

Mehta S and 11 others. Cancer Cell, 2011. Cited by 146 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma. Papers, record 21397859. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/21397859

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma.
PubMed
Journal
Cancer Cell
PubMed
Year
2011
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
146
iCite
Relative citation ratio, by iCite
3.1
iCite
Revised in PubMed
2026-01-28
PubMed

Authors12

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Mehta SShwetal
2Huillard EEmmanuelle
3Kesari SSantosh
4Maire CLCecile L
5Golebiowski DDiane
6Harrington EPEmily P
7Alberta JAJohn A
8Kane MFMichael F
9Theisen MMatthew
10Ligon KLKeith L

1 to 10 of 12Source PubMed

See all 12 authors

Topics26

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Basic Helix-Loop-Helix ProteinsMajor topic
DNA DamageMajor topic
GliomaMajor topic
Nerve Tissue ProteinsMajor topic
Neural Stem CellsMajor topic
Tumor Suppressor Protein p53Major topic
Animals
Apoptosis
Cell Survival
Cells, Cultured
Central Nervous System
Cyclin-Dependent Kinase Inhibitor p21
Female
Flow Cytometry
HEK293 Cells
Humans
Immunoblotting
Male
Mice
Mice, 129 Strain
Mice, Knockout
Mice, SCID
Oligodendrocyte Transcription Factor 2
Phosphorylation
Promoter Regions, Genetic
Protein Binding

Source PubMed

Grants9

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
NS05563NINDS NIH HHSUnited StatesF32NS005563PubMed and NIHNIH RePORTER
R01 NS057727NINDS NIH HHSUnited StatesR01NS057727PubMed and NIHNIH RePORTER
F32 NS055631NINDS NIH HHSUnited StatesF32NS055631PubMed and NIHNIH RePORTER
Howard Hughes Medical InstituteUnited StatesPubMedPubMed
NS047213NINDS NIH HHSUnited StatesK08NS047213PubMed and NIHNIH RePORTER
NS057727NINDS NIH HHSUnited StatesR01NS057727PubMed and NIHNIH RePORTER
K08 NS047213NINDS NIH HHSUnited StatesK08NS047213PubMed and NIHNIH RePORTER
NS040511NINDS NIH HHSUnited StatesR01NS040511PubMed and NIHNIH RePORTER
R01 NS040511NINDS NIH HHSUnited StatesR01NS040511PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Comment in21,382,543All the embryo's a stage, and Olig2 in its time plays many parts.https://conductscience.org/library/papers/21382543

Source PubMed

References71

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
18,504,413Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.Cancer Res1993https://conductscience.org/library/papers/8504413PubMed
217,075,578The cancer stem cell hypothesis: a work in progress.Lab Invest2006https://conductscience.org/library/papers/17075578PubMed
320,596,026Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271.Nature2010https://conductscience.org/library/papers/20596026PubMed
415,198,128The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas.J Neuropathol Exp Neurol2004https://conductscience.org/library/papers/15198128PubMed
58,242,752WAF1, a potential mediator of p53 tumor suppression.Cell1993https://conductscience.org/library/papers/8242752PubMed
69,049,885Treatment of pediatric low-grade gliomas with a nitrosourea-based multiagent chemotherapy regimen.J Neurooncol1997https://conductscience.org/library/papers/9049885PubMed
719,052,611Cancer stem cells: Here, there, everywhere?Nature2008https://conductscience.org/library/papers/19052611PubMed
812,121,626The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages.Curr Biol2002https://conductscience.org/library/papers/12121626PubMed
917,051,156Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.Nature2006https://conductscience.org/library/papers/17051156PubMed
101,552,940Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours.Nature1992https://conductscience.org/library/papers/1552940PubMed

1 to 10 of 71

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Cited by110

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 146 citations.

PMIDTitleJournalYearIn PapersSource
42,222,434OLIG2-STAT5 cooperation supports glioma stem cell maintenance and proliferation in glioblastoma.Neurooncol Adv2026https://conductscience.org/library/papers/42222434PubMed
42,222,374Modeling gliomas with organoids: reconstructing the human neural microenvironment for translational neuro-oncology.Front Oncol2026https://conductscience.org/library/papers/42222374PubMed
41,827,793Translating Molecular Insights into Effective Targeting of Glioblastoma Stem Cells.Cancers (Basel)2026https://conductscience.org/library/papers/41827793PubMed
41,683,962Targeting Pediatric Glioblastomas by Combining OLIG2 Inhibitor CT-179 with Fractionated Radiation in a Panel of Patient-Derived Orthotopic Xenograft Mouse Models.Int J Mol Sci2026https://conductscience.org/library/papers/41683962PubMed
40,369,078Oncogenic fusions converge on shared mechanisms in initiating astroblastoma.Nature2025https://conductscience.org/library/papers/40369078PubMed
40,277,888Glioblastoma Stem Cells at the Nexus of Tumor Heterogeneity, Immune Evasion, and Therapeutic Resistance.Cells2025https://conductscience.org/library/papers/40277888PubMed
39,970,230A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma.Sci Transl Med2025https://conductscience.org/library/papers/39970230PubMed
39,904,987OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma.Nat Commun2025https://conductscience.org/library/papers/39904987PubMed
39,374,171Diverse functions of DEAD-box proteins in oligodendrocyte development, differentiation, and homeostasis.J Neurochem2025https://conductscience.org/library/papers/39374171PubMed
39,273,649Roles of Histone H2B, H3 and H4 Variants in Cancer Development and Prognosis.Int J Mol Sci2024https://conductscience.org/library/papers/39273649PubMed

1 to 10 of 110

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Genes23

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ATM472PubTator's text mininghttps://conductscience.org/library/genes/472NCBI Gene
BAX581PubTator's text mininghttps://conductscience.org/library/genes/581NCBI Gene
BBC327,113PubTator's text mininghttps://conductscience.org/library/genes/27113NCBI Gene
BRD729,117PubTator's text mininghttps://conductscience.org/library/genes/29117NCBI Gene
CASP3836PubTator's text mininghttps://conductscience.org/library/genes/836NCBI Gene
CDKN1A1,026PubTator's text mininghttps://conductscience.org/library/genes/1026NCBI Gene
CDKN2A1,029PubTator's text mininghttps://conductscience.org/library/genes/1029NCBI Gene
CSPG41,464PubTator's text mininghttps://conductscience.org/library/genes/1464NCBI Gene
EP3002,033PubTator's text mininghttps://conductscience.org/library/genes/2033NCBI Gene
FANCL55,120PubTator's text mininghttps://conductscience.org/library/genes/55120NCBI Gene

1 to 10 of 23

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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