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Paper · 214510

The biologic significance of alloreactivity. The ontogeny of T-cell sets specific for alloantigens or modified self antigens.

Burakoff SJ and 5 others. J Exp Med, 1978. Cited by 131 papers, by iCite.

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ConductScience Library. The biologic significance of alloreactivity. The ontogeny of T-cell sets specific for alloantigens or modified self antigens. Papers, record 214510. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/214510

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The biologic significance of alloreactivity. The ontogeny of T-cell sets specific for alloantigens or modified self antigens.
PubMed
Journal
J Exp Med
PubMed
Year
1978
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
131
iCite
Relative citation ratio, by iCite
2.83
iCite
Revised in PubMed
2019-05-08
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Burakoff SJS J
2Finberg RR
3Glimcher LL
4Lemonnier FF
5Benacerraf BB
6Cantor HH

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AntigensMajor topic
AutoantigensMajor topic
Cytotoxicity, ImmunologicMajor topic
Immunologic MemoryMajor topic
IsoantigensMajor topic
Major Histocompatibility ComplexMajor topic
T-LymphocytesMajor topic
Animals
Cross Reactions
Female
Immunity, Cellular
Male
Mice
Mice, Inbred Strains
Parainfluenza Virus 1, Human

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References18

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1233,899Histocompatibility antigen-activated cytotoxic T lymphocytes. II. Estimates of the frequency and specificity of precursors.J Exp Med1977https://conductscience.org/library/papers/233899PubMed
25,682,942Quantitative studies on the mixed lymphocyte interaction in rats. 3. Kinetics of the response.J Exp Med1968https://conductscience.org/library/papers/5682942PubMed
373,180Mouse cytolytic T lymphocytes induced by xenogeneic rat stimulator cells exhibit specificity for H-2 complex alloantigens.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/73180PubMed
4330,390Quantitative studies of the activation of cytotoxic lymphocyte precursor cells.Immunol Rev1977https://conductscience.org/library/papers/330390PubMed
5320,663Functional specificity of thymus- dependent lymphocytes.Science1977https://conductscience.org/library/papers/320663PubMed
6305,459On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?J Exp Med1978https://conductscience.org/library/papers/305459PubMed
7306,405Immunoregulatory circuits among T-cell sets. I. T-helper cells induce other T-cell sets to exert feedback inhibition.J Exp Med1978https://conductscience.org/library/papers/306405PubMed
8304,579Ly phenotype of T cells cytotoxic for syngeneic mouse mammary tumors: evidence for T cell interactions.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/304579PubMed
9300,484Cytolytic thymus-derived lymphocytes specific for allogeneic stimulator cells crossreact with chemically modified syngeneic cells.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/300484PubMed
10302,190Regulation of cellular and humoral immune responses by T-cell subclasses.Cold Spring Harb Symp Quant Biol1977https://conductscience.org/library/papers/302190PubMed

1 to 10 of 18

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Cited by35

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 131 citations.

PMIDTitleJournalYearIn PapersSource
22,457,931Anti H-2Dd alloreactivity mediated by herpes-simplex-virus specific cytotoxic H-2k T lymphocytes is associated with H-2Dk.Immunogenetics1980https://conductscience.org/library/papers/22457931PubMed
6,980,965Induction of neonatal tolerance to H-2k in B6 mice does not allow the emergence of T cells specific for H-2k plus vaccinia virus.J Exp Med1982https://conductscience.org/library/papers/6980965PubMed
6,972,039Effects of Lyt antibodies on T-cell functions: augmentation by anti-Lyt-1 as opposed to inhibition by anti-Lyt-2.Proc Natl Acad Sci U S A1981https://conductscience.org/library/papers/6972039PubMed
6,969,780Cytotoxic T lymphocyte responses by chimeric thymocytes. Self-recognition is determined early in T cell development.J Exp Med1981https://conductscience.org/library/papers/6969780PubMed
6,968,813Alloreactive and H-2-restricted Lyt 23 cytotoxic T lymphocytes derive from a common pool of antecedent Lyt 123 precursors.J Exp Med1980https://conductscience.org/library/papers/6968813PubMed
6,967,859Use of H-2 mutations to quantitate alloreactivity: Alloreactivity is strongest against H-2 antigens which are closet to self.Immunogenetics1980https://conductscience.org/library/papers/6967859PubMed
6,966,321Self H-2 antigens influence the specificity of alloreactive cells.J Exp Med1980https://conductscience.org/library/papers/6966321PubMed
6,965,305T cells that encounter virus in the complete absence of a particular H-2 antigen are nonresponsive when stimulated again in the context of that H-2 antigen.J Exp Med1980https://conductscience.org/library/papers/6965305PubMed
6,804,386Ontogeny of murine macrophages: functions related to antigen presentation.Infect Immun1982https://conductscience.org/library/papers/6804386PubMed
6,792,057The inductive requirements for the primary in vitro generation of delayed-type hypersensitivity response to influenza virus in mice.Immunology1981https://conductscience.org/library/papers/6792057PubMed

1 to 10 of 35

See all 35 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
HLA-C3,107PubTator's text mininghttps://conductscience.org/library/genes/3107

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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