Paper · 22001963

Heparanase expression is associated with histone modifications in glioblastoma.

Hong X and 3 others. Int J Oncol, 2012. Cited by 11 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Heparanase expression is associated with histone modifications in glioblastoma. Papers, record 22001963. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/22001963

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Heparanase expression is associated with histone modifications in glioblastoma.; PubMed
Journal: Int J Oncol; PubMed
Year: 2012; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/22001963/; PubMed
DOI: https://doi.org/10.3892/ijo.2011.1229; PubMed
The journal: https://conductscience.org/library/journal-index/9306042; PubMed
Citations, by iCite: 11; iCite
Relative citation ratio, by iCite: 0.28; iCite
Revised in PubMed: 2026-01-28; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Hong X	Xin
2	Nelson K	Kevin
3	Lemke N	Nancy
4	Kalkanis SN	Steven N

Source PubMed

Topics21

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Gene Expression	Major topic
Glioblastoma	Major topic
Glucuronidase	Major topic
Histones	Major topic
Azacitidine
Base Sequence
Cell Line, Tumor
CpG Islands
DNA Modification Methylases
Decitabine
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Histone Deacetylase Inhibitors
Humans
Hydroxamic Acids
Molecular Sequence Data
NF-kappa B p50 Subunit
Promoter Regions, Genetic
Protein Processing, Post-Translational
Transcription Factor RelA
Heparanase

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by9

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 11 citations.

PMID	Title	Journal	Year	In Papers	Source
42,449,924	Auranofin Suppresses Cancer Cell Invasion by Inhibiting Heparanase-1 Expression via the aPKC-NF-κB Pathway.	Int J Mol Sci	2026	https://conductscience.org/library/papers/42449924	PubMed
41,960,188	Acetylation modification in malignant progression and therapeutic resistance of gliomas.	Front Cell Dev Biol	2026	https://conductscience.org/library/papers/41960188	PubMed
33,748,723	Dissociation of DNA damage sensing by endoglycosidase HPSE.	iScience	2021	https://conductscience.org/library/papers/33748723	PubMed
33,621,216	Disruption of innate defense responses by endoglycosidase HPSE promotes cell survival.	JCI Insight	2021	https://conductscience.org/library/papers/33621216	PubMed
33,547,534	5-Aza-2'-deoxycytidine induces a greater inflammatory change, at the molecular levels, in normoxic than hypoxic tumor microenvironment.	Mol Biol Rep	2021	https://conductscience.org/library/papers/33547534	PubMed
32,075,104	Chemoradiotherapy Increases Intratumor Heterogeneity of HPSE Expression in the Relapsed Glioblastoma Tumors.	Int J Mol Sci	2020	https://conductscience.org/library/papers/32075104	PubMed
28,700,944	Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1.	Cell Rep	2017	https://conductscience.org/library/papers/28700944	PubMed
25,745,999	Nuclear heparanase-1 activity suppresses melanoma progression via its DNA-binding affinity.	Oncogene	2015	https://conductscience.org/library/papers/25745999	PubMed
24,632,672	DNA methylation of heparanase promoter influences its expression and associated with the progression of human breast cancer.	PLoS One	2014	https://conductscience.org/library/papers/24632672	PubMed

Genes6

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
EGR1	1,958	PubTator's text mining	https://conductscience.org/library/genes/1958	NCBI Gene
ETS1	2,113	PubTator's text mining	https://conductscience.org/library/genes/2113	NCBI Gene
GABPA	2,551	PubTator's text mining	https://conductscience.org/library/genes/2551	NCBI Gene
HPSE	10,855	PubTator's text mining	https://conductscience.org/library/genes/10855	NCBI Gene
NFKB1	4,790	PubTator's text mining	https://conductscience.org/library/genes/4790	NCBI Gene
RELA	5,970	PubTator's text mining	https://conductscience.org/library/genes/5970	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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