Paper22079

Human leukocytic pyrogen: purification and development of a radioimmunoassay.

Dinarello CA and 2 others. Proc Natl Acad Sci U S A, 1977. Cited by 269 papers, by iCite.

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ConductScience Library. Human leukocytic pyrogen: purification and development of a radioimmunoassay. Papers, record 22079. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/22079

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Human leukocytic pyrogen: purification and development of a radioimmunoassay.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 1977; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/22079/; PubMed
DOI: https://doi.org/10.1073/pnas.74.10.4624; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC431999/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 269; iCite
Relative citation ratio, by iCite: 5.32; iCite
Revised in PubMed: 2022-04-19; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Dinarello CA	C A
2	Renfer L	L
3	Wolff SM	S M

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Leukocytes	Major topic
Pyrogens	Major topic
Antibodies
Chromatography, Gel
Chromatography, Ion Exchange
Humans
Hydrogen-Ion Concentration
Immunosorbent Techniques
Iodine Radioisotopes
Methods
Radioimmunoassay

Source PubMed

Show 5 more topicsShow fewer topics

References10

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	4,550,084	Fever.	N Engl J Med	1972	https://conductscience.org/library/papers/4550084	PubMed
2	4,621,751	On the demonstration of circulating human endogenous pyrogen.	Proc Soc Exp Biol Med	1972	https://conductscience.org/library/papers/4621751	PubMed
3	4,733,239	The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent.	Biochem J	1973	https://conductscience.org/library/papers/4733239	PubMed
4	4,829,934	Demonstration and characterization of two distinct human leukocytic pyrogens.	J Exp Med	1974	https://conductscience.org/library/papers/4829934	PubMed
5	4,910,480	Factors affecting the quantitative production and assay of human leukocytic pyrogen.	J Lab Clin Med	1970	https://conductscience.org/library/papers/4910480	PubMed
6	4,971,842	Selective enzyme purification by affinity chromatography.	Proc Natl Acad Sci U S A	1968	https://conductscience.org/library/papers/4971842	PubMed
7	5,430,786	Studies on the origin of human leukocytic pyrogen.	J Exp Med	1970	https://conductscience.org/library/papers/5430786	PubMed
8	5,548,524	Transferable pyrogen in human experimental fever.	Clin Sci	1971	https://conductscience.org/library/papers/5548524	PubMed
9	559,692	The production of antibody against human leukocytic pyrogen.	J Clin Invest	1977	https://conductscience.org/library/papers/559692	PubMed
10	5,935,620	Human leukocyte pyrogen producing fever in rabbits.	Proc Soc Exp Biol Med	1966	https://conductscience.org/library/papers/5935620	PubMed

Show 4 more referencesShow fewer references

Cited by78

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 269 citations.

PMID	Title	Journal	Year	In Papers	Source
41,369,412	Linking AIM2 Inflammasome Activation, Mitochondrial Dysfunction and Chronic Inflammation in Ankylosing Spondylitis.	Cells	2025	https://conductscience.org/library/papers/41369412	PubMed
41,214,288	IL-1 family of cytokines in gastrointestinal and liver disorders.	Nat Rev Gastroenterol Hepatol	2026	https://conductscience.org/library/papers/41214288	PubMed
40,620,892	Interleukins as a potential link between obstructive sleep apnea and renal cell carcinoma.	Contemp Oncol (Pozn)	2025	https://conductscience.org/library/papers/40620892	PubMed
39,496,966	Targeting the NLRP3 inflammasome-IL-1β pathway in type 2 diabetes and obesity.	Diabetologia	2025	https://conductscience.org/library/papers/39496966	PubMed
39,117,838	IL-1 Family Blockade in Cytokine Storm Syndromes.	Adv Exp Med Biol	2024	https://conductscience.org/library/papers/39117838	PubMed
38,372,637	Role for Caspase-8 in the Release of IL-1β and Active Caspase-1 from Viable Human Monocytes during Toxoplasma gondii Infection.	J Immunol	2024	https://conductscience.org/library/papers/38372637	PubMed
37,031,383	Beyond an inflammatory mediator: Interleukin-1 in neurophysiology.	Exp Physiol	2023	https://conductscience.org/library/papers/37031383	PubMed
36,613,465	The IL-1 Family and Its Role in Atherosclerosis.	Int J Mol Sci	2022	https://conductscience.org/library/papers/36613465	PubMed
36,220,098	In situ cell-type-specific cell-surface proteomic profiling in mice.	Neuron	2022	https://conductscience.org/library/papers/36220098	PubMed
35,805,534	Analysis of the Serum Profile of Cytokines Involved in the T-Helper Cell Type 17 Immune Response Pathway in Atopic Children with Food Allergy.	Int J Environ Res Public Health	2022	https://conductscience.org/library/papers/35805534	PubMed
34,580,455	The inflammasome: from bench to bedside.	Nat Rev Immunol	2021	https://conductscience.org/library/papers/34580455	PubMed
34,285,393	Immune-based therapies in cardiovascular and metabolic diseases: past, present and future.	Nat Rev Immunol	2021	https://conductscience.org/library/papers/34285393	PubMed
34,054,881	Editorial: Cytokines and Intestinal Mucosal Immunity.	Front Immunol	2021	https://conductscience.org/library/papers/34054881	PubMed
33,916,672	Predictive Periodontitis: The Most Promising Salivary Biomarkers for Early Diagnosis of Periodontitis.	J Clin Med	2021	https://conductscience.org/library/papers/33916672	PubMed
31,515,542	The IL-1 family of cytokines and receptors in rheumatic diseases.	Nat Rev Rheumatol	2019	https://conductscience.org/library/papers/31515542	PubMed
31,124,430	Innate and Adaptive Immune Responses during Listeria monocytogenes Infection.	Microbiol Spectr	2019	https://conductscience.org/library/papers/31124430	PubMed
31,110,285	IL-1α promotes liver inflammation and necrosis during blood-stage Plasmodium chabaudi malaria.	Sci Rep	2019	https://conductscience.org/library/papers/31110285	PubMed
30,995,508	Cytokine Circuits in Cardiovascular Disease.	Immunity	2019	https://conductscience.org/library/papers/30995508	PubMed
30,459,597	Anakinra Therapy for Non-cancer Inflammatory Diseases.	Front Pharmacol	2018	https://conductscience.org/library/papers/30459597	PubMed
29,390,386	Hemophagocytic lymphohistiocytosis in an adult kidney transplant recipient successfully treated by plasmapheresis: A case report and review of the literature.	Medicine (Baltimore)	2017	https://conductscience.org/library/papers/29390386	PubMed

Show 14 more cited byShow fewer cited bySee all 78 cited by

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

None in this release

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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