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Paper23144635

A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation.

Yamtich J and 3 others. PLoS Genet, 2012. Cited by 68 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation. Papers, record 23144635. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/23144635

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation.
PubMed
Journal
PLoS Genet
PubMed
Year
2012
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural
PubMed
Citations, by iCite
68
iCite
Relative citation ratio, by iCite
1.6
iCite
Revised in PubMed
2022-02-23
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Yamtich JJennifer
2Nemec AAAntonia A
3Keh AAgnes
4Sweasy JBJoann B

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cell Transformation, NeoplasticMajor topic
Chromosome AberrationsMajor topic
DNA Polymerase betaMajor topic
Genomic InstabilityMajor topic
Polymorphism, Single NucleotideMajor topic
Animals
Cell Line
DNA Breaks, Double-Stranded
DNA Breaks, Single-Stranded
DNA Damage
DNA Repair
Disease Susceptibility
Gene Expression Regulation
Germ Cells
Humans
Mice
Oxidative Stress

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
F32 CA156843NCI NIH HHSUnited StatesF32CA156843PubMed and NIHNIH RePORTER
P01 CA129186NCI NIH HHSUnited StatesP01CA129186PubMed and NIHNIH RePORTER

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Comment in23,144,636Genome instability caused by a germline mutation in the human DNA repair gene POLB.https://conductscience.org/library/papers/23144636

Source PubMed

References36

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
112,376,507Identification of 127 amino acid substitution variants in screening 37 DNA repair genes in humans.Cancer Epidemiol Biomarkers Prev2002https://conductscience.org/library/papers/12376507PubMed
214,992,725A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology.Mol Cell2004https://conductscience.org/library/papers/14992725PubMed
315,751,954Hinge residue Ile260 of DNA polymerase beta is important for enzyme activity and fidelity.Biochemistry2005https://conductscience.org/library/papers/15751954PubMed
415,075,389A DNA polymerase beta mutant from colon cancer cells induces mutations.Proc Natl Acad Sci U S A2004https://conductscience.org/library/papers/15075389PubMed
58,469,282Instability and decay of the primary structure of DNA.Nature1993https://conductscience.org/library/papers/8469282PubMed
616,609,022Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer.Clin Cancer Res2006https://conductscience.org/library/papers/16609022PubMed
717,526,740The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation.Mol Cell Biol2007https://conductscience.org/library/papers/17526740PubMed
818,006,695Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis.Blood2008https://conductscience.org/library/papers/18006695PubMed
916,979,388DNA polymerase beta null mouse embryonic fibroblasts harbor a homozygous null mutation in DNA polymerase iota.DNA Repair (Amst)2007https://conductscience.org/library/papers/16979388PubMed
1017,855,454Genetic variation in the DNA repair genes is predictive of outcome in lung cancer.Hum Mol Genet2007https://conductscience.org/library/papers/17855454PubMed
1114,563,842The D246V mutant of DNA polymerase beta misincorporates nucleotides: evidence for a role for the flexible loop in DNA positioning within the active site.J Biol Chem2004https://conductscience.org/library/papers/14563842PubMed
1220,573,551Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks.DNA Repair (Amst)2010https://conductscience.org/library/papers/20573551PubMed
1321,452,873A triad interaction in the fingers subdomain of DNA polymerase beta controls polymerase activity.J Am Chem Soc2011https://conductscience.org/library/papers/21452873PubMed
1410,966,791DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA polymerase with a potential role in meiosis.J Mol Biol2000https://conductscience.org/library/papers/10966791PubMed
1510,585,471The E249K mutator mutant of DNA polymerase beta extends mispaired termini.J Biol Chem1999https://conductscience.org/library/papers/10585471PubMed
1610,716,939Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta.EMBO J2000https://conductscience.org/library/papers/10716939PubMed
1726,810Helper-independent transformation by unintegrated Harvey sarcoma virus DNA.J Virol1978https://conductscience.org/library/papers/26810PubMed
1816,464,010Structure and mechanism of DNA polymerase Beta.Chem Rev2006https://conductscience.org/library/papers/16464010PubMed
198,396,240High efficiency, restriction-deficient in vitro packaging extracts for bacteriophage lambda DNA using a new E.coli lysogen.Nucleic Acids Res1993https://conductscience.org/library/papers/8396240PubMed
2015,568,983Repair and genetic consequences of endogenous DNA base damage in mammalian cells.Annu Rev Genet2004https://conductscience.org/library/papers/15568983PubMed

See all 36 references

Cited by57

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 68 citations.

PMIDTitleJournalYearIn PapersSource
42,378,620Biochemical, structural and mutational landscapes of base excision repair enzymes and cancer: from atomic resolution to tumor signatures.Int J Radiat Biol2026https://conductscience.org/library/papers/42378620PubMed
41,568,291Harnessing DNA polymerase beta defect enhances synthetic lethality and treatment response in gastric cancer cells: implication for immunotherapy.J Pharm Pharm Sci2025https://conductscience.org/library/papers/41568291PubMed
40,081,282Repair pathway coordination from gap filling by polβ and subsequent nick sealing by LIG1 or LIG3α governs BER efficiency at the downstream steps.DNA Repair (Amst)2025https://conductscience.org/library/papers/40081282PubMed
39,402,431Aberrant DNA polymerase beta expression is associated with dysregulated tumor immune microenvironment and its prognostic value in gastric cancer.Clin Exp Med2024https://conductscience.org/library/papers/39402431PubMed
38,619,421Mouse models to explore the biological and organismic role of DNA polymerase beta.Environ Mol Mutagen2024https://conductscience.org/library/papers/38619421PubMed
38,366,780Unfilled gaps by polβ lead to aberrant ligation by LIG1 at the downstream steps of base excision repair pathway.Nucleic Acids Res2024https://conductscience.org/library/papers/38366780PubMed
38,245,510DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1.Cell Death Dis2024https://conductscience.org/library/papers/38245510PubMed
37,174,699The Activity of Natural Polymorphic Variants of Human DNA Polymerase β Having an Amino Acid Substitution in the Transferase Domain.Cells2023https://conductscience.org/library/papers/37174699PubMed
36,982,964Human Polβ Natural Polymorphic Variants G118V and R149I Affects Substate Binding and Catalysis.Int J Mol Sci2023https://conductscience.org/library/papers/36982964PubMed
35,794,098A novel mechanism for macrophage pyroptosis in rheumatoid arthritis induced by Pol β deficiency.Cell Death Dis2022https://conductscience.org/library/papers/35794098PubMed
35,327,359Role of Base Excision Repair in Innate Immune Cells and Its Relevance for Cancer Therapy.Biomedicines2022https://conductscience.org/library/papers/35327359PubMed
35,216,513The Role of Natural Polymorphic Variants of DNA Polymerase β in DNA Repair.Int J Mol Sci2022https://conductscience.org/library/papers/35216513PubMed
34,556,055Interplay and cooperation of Helicobacter pylori and gut microbiota in gastric carcinogenesis.BMC Microbiol2021https://conductscience.org/library/papers/34556055PubMed
34,144,266DNA polymerase β deficiency promotes the occurrence of esophageal precancerous lesions in mice.Neoplasia2021https://conductscience.org/library/papers/34144266PubMed
33,875,663STING enhances cell death through regulation of reactive oxygen species and DNA damage.Nat Commun2021https://conductscience.org/library/papers/33875663PubMed
33,673,690Silencing DNA Polymerase β Induces Aneuploidy as a Biomarker of Poor Prognosis in Oral Squamous Cell Cancer.Int J Mol Sci2021https://conductscience.org/library/papers/33673690PubMed
33,285,475Towards a comprehensive view of 8-oxo-7,8-dihydro-2'-deoxyguanosine: Highlighting the intertwined roles of DNA damage and epigenetics in genomic instability.DNA Repair (Amst)2021https://conductscience.org/library/papers/33285475PubMed
32,641,859DNA polymerase beta modulates cancer progression via enhancing CDH13 expression by promoter demethylation.Oncogene2020https://conductscience.org/library/papers/32641859PubMed
32,547,565Base Excision Repair in the Immune System: Small DNA Lesions With Big Consequences.Front Immunol2020https://conductscience.org/library/papers/32547565PubMed
31,880,305The double-edged sword of cancer mutations: exploiting neoepitopes for the fight against cancer.Mutagenesis2020https://conductscience.org/library/papers/31880305PubMed

See all 57 cited by

Genes6

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
EGF1,950PubTator's text mininghttps://conductscience.org/library/genes/1950NCBI Gene
INS3,630PubTator's text mininghttps://conductscience.org/library/genes/3630NCBI Gene
PARP1142PubTator's text mininghttps://conductscience.org/library/genes/142NCBI Gene
PCNA5,111PubTator's text mininghttps://conductscience.org/library/genes/5111NCBI Gene
POLB5,423PubTator's text mininghttps://conductscience.org/library/genes/5423NCBI Gene
PRMT13,276PubTator's text mininghttps://conductscience.org/library/genes/3276NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Trials
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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