Paper · 24677718

Hyaluronan and hyaluronan-binding proteins accumulate in both human type 1 diabetic islets and lymphoid tissues and associate with inflammatory cells in insulitis.

Bogdani M and 6 others. Diabetes, 2014. Cited by 97 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Hyaluronan and hyaluronan-binding proteins accumulate in both human type 1 diabetic islets and lymphoid tissues and associate with inflammatory cells in insulitis. Papers, record 24677718. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/24677718

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Hyaluronan and hyaluronan-binding proteins accumulate in both human type 1 diabetic islets and lymphoid tissues and associate with inflammatory cells in insulitis.; PubMed
Journal: Diabetes; PubMed
Year: 2014; PubMed
Publication types: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/24677718/; PubMed
DOI: https://doi.org/10.2337/db13-1658; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC4113060/; PubMed
The journal: https://conductscience.org/library/journal-index/0372763; PubMed
Citations, by iCite: 97; iCite
Relative citation ratio, by iCite: 3.04; iCite
Revised in PubMed: 2021-10-21; PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Bogdani M	Marika
2	Johnson PY	Pamela Y
3	Potter-Perigo S	Susan
4	Nagy N	Nadine
5	Day AJ	Anthony J
6	Bollyky PL	Paul L
7	Wight TN	Thomas N

Source PubMed

Topics20

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Diabetes Mellitus, Type 1	Major topic
Hyaluronan Receptors	Major topic
Hyaluronic Acid	Major topic
Inflammation	Major topic
Islets of Langerhans	Major topic
Lymphoid Tissue	Major topic
Adult
Aged
Aging
Alpha-Globulins
Case-Control Studies
Cell Adhesion Molecules
Child
Child, Preschool
Gene Expression Regulation
Humans
Infant
Insulin
Middle Aged
Versicans

Source PubMed

Grants9

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
U01-AI-101984	NIAID NIH HHS	United States	U01AI101984	PubMed and NIH	NIH RePORTER
R01 DK096087	NIDDK NIH HHS	United States	R01DK096087	PubMed and NIH	NIH RePORTER
R01-DK-096087	NIDDK NIH HHS	United States	R01DK096087	PubMed and NIH	NIH RePORTER
R01-AR-03729	NIAMS NIH HHS	United States		PubMed	PubMed
P30-DK-17047	NIDDK NIH HHS	United States	P30DK017047	PubMed and NIH	NIH RePORTER
R01-HL-113294	NHLBI NIH HHS	United States	R01HL113294	PubMed and NIH	NIH RePORTER
P30 DK017047	NIDDK NIH HHS	United States	P30DK017047	PubMed and NIH	NIH RePORTER
R01 HL113294	NHLBI NIH HHS	United States	R01HL113294	PubMed and NIH	NIH RePORTER
U01 AI101984	NIAID NIH HHS	United States	U01AI101984	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References55

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	15,277,383	Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways.	Diabetes	2004	https://conductscience.org/library/papers/15277383	PubMed
2	19,352,320	The role of inflammation in insulitis and beta-cell loss in type 1 diabetes.	Nat Rev Endocrinol	2009	https://conductscience.org/library/papers/19352320	PubMed
3	8,724,014	The structure and function of hyaluronan: An overview.	Immunol Cell Biol	1996	https://conductscience.org/library/papers/8724014	PubMed
4	15,923,354	Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy.	J Histochem Cytochem	2005	https://conductscience.org/library/papers/15923354	PubMed
5	17,067,937	Normal structure, function, and histology of lymph nodes.	Toxicol Pathol	2006	https://conductscience.org/library/papers/17067937	PubMed
6	23,333,375	Hyaluronan oligosaccharides perturb lymphocyte slow rolling on brain vascular endothelial cells: implications for inflammatory demyelinating disease.	Matrix Biol	2013	https://conductscience.org/library/papers/23333375	PubMed
7	12,615,203	Hyaluronan--magic glue for the regulation of the immune response?	Trends Immunol	2003	https://conductscience.org/library/papers/12615203	PubMed
8	18,633,594	Molecular composition of the peri-islet basement membrane in NOD mice: a barrier against destructive insulitis.	Diabetologia	2008	https://conductscience.org/library/papers/18633594	PubMed
9	11,581,169	Spatial and molecular organization of lymph node T cell cortex: a labyrinthine cavity bounded by an epithelium-like monolayer of fibroblastic reticular cells anchored to basement membrane-like extracellular matrix.	Int Immunol	2001	https://conductscience.org/library/papers/11581169	PubMed
10	22,821,669	Hyaluronan and hyaluronan binding proteins are normal components of mouse pancreatic islets and are differentially expressed by islet endocrine cell types.	J Histochem Cytochem	2012	https://conductscience.org/library/papers/22821669	PubMed

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Cited by77

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 97 citations.

PMID	Title	Journal	Year	In Papers	Source
42,836,088	Hyaluronan Accumulates in Inflamed Lymph Nodes and Promotes B-Cell Activation.	Proteoglycan Res	2025	https://conductscience.org/library/papers/42836088	PubMed
42,338,479	Naive CD4+ T cells synthesize a hyaluronan-rich glycocalyx that is diminished following activation.	iScience	2026	https://conductscience.org/library/papers/42338479	PubMed
41,816,223	Hyaluronan induces ERK activation with minimal transcriptomic changes in pancreatic α-cells.	Biochem Biophys Rep	2026	https://conductscience.org/library/papers/41816223	PubMed
39,767,698	Beneficial Actions of 4-Methylumbelliferone in Type 1 Diabetes by Promoting β Cell Renewal and Inhibiting Dedifferentiation.	Biomedicines	2024	https://conductscience.org/library/papers/39767698	PubMed
39,451,245	Hymecromone Promotes Longevity and Insulin Sensitivity in Mice.	Cells	2024	https://conductscience.org/library/papers/39451245	PubMed
39,329,947	Brain Ischemic Tolerance Triggered by Preconditioning Involves Modulation of Tumor Necrosis Factor-α-Stimulated Gene 6 (TSG-6) in Mice Subjected to Transient Middle Cerebral Artery Occlusion.	Curr Issues Mol Biol	2024	https://conductscience.org/library/papers/39329947	PubMed
39,316,441	Proteogenomic analysis integrated with electronic health records data reveals disease-associated variants in Black Americans.	J Clin Invest	2024	https://conductscience.org/library/papers/39316441	PubMed
38,803,329	Extracellular matrix stiffness mediates insulin secretion in pancreatic islets via mechanosensitive Piezo1 channel regulated Ca2+ dynamics.	Matrix Biol Plus	2024	https://conductscience.org/library/papers/38803329	PubMed
38,548,914	Role of endothelial hyaluronan in peritoneal membrane transport and disease conditions during peritoneal dialysis.	Sci Rep	2024	https://conductscience.org/library/papers/38548914	PubMed
38,454,609	Diabetes as a Pancreatic Microvascular Disease-A Pericytic Perspective.	J Histochem Cytochem	2024	https://conductscience.org/library/papers/38454609	PubMed

1 to 10 of 77

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Genes12

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
GCG	2,641	PubTator's text mining	https://conductscience.org/library/genes/2641	NCBI Gene
GRHL3	57,822	PubTator's text mining	https://conductscience.org/library/genes/57822	NCBI Gene
INS	3,630	PubTator's text mining	https://conductscience.org/library/genes/3630	NCBI Gene
KRT20	54,474	PubTator's text mining	https://conductscience.org/library/genes/54474	NCBI Gene
PECAM1	5,175	PubTator's text mining	https://conductscience.org/library/genes/5175	NCBI Gene
PPY	5,539	PubTator's text mining	https://conductscience.org/library/genes/5539	NCBI Gene
PTPRC	5,788	PubTator's text mining	https://conductscience.org/library/genes/5788	NCBI Gene
SST	6,750	PubTator's text mining	https://conductscience.org/library/genes/6750	NCBI Gene
SYP	6,855	PubTator's text mining	https://conductscience.org/library/genes/6855	NCBI Gene
TNFAIP6	7,130	PubTator's text mining	https://conductscience.org/library/genes/7130	NCBI Gene

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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