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Paper · 2497464

Developmental control of lymphokine gene expression in fetal thymocytes during T-cell ontogeny.

Carding SR and 5 others. Proc Natl Acad Sci U S A, 1989. Cited by 74 papers, by iCite.

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ConductScience Library. Developmental control of lymphokine gene expression in fetal thymocytes during T-cell ontogeny. Papers, record 2497464. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/2497464

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Developmental control of lymphokine gene expression in fetal thymocytes during T-cell ontogeny.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1989
PubMed
Publication types
Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
74
iCite
Relative citation ratio, by iCite
1.3
iCite
Revised in PubMed
2019-05-01
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Carding SRS R
2Jenkinson EJE J
3Kingston RR
4Hayday ACA C
5Bottomly KK
6Owen JJJ J

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Gene Expression RegulationMajor topic
Interferon-gammaMajor topic
Interleukin-2Major topic
InterleukinsMajor topic
T-LymphocytesMajor topic
Thymus GlandMajor topic
Animals
DNA Probes
Gestational Age
Interleukin-4
Mice
Mice, Inbred CBA
Nucleic Acid Hybridization
RNA, Messenger
Receptors, Interleukin-2

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References27

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
16,832,211Flow microfluorometric analysis of mouse thymus development in vivo and in vitro.Eur J Immunol1983https://conductscience.org/library/papers/6832211PubMed
22,893,823Proliferation and production of IL-2 and B cell stimulatory factor 1/IL-4 in early fetal thymocytes by activation through Thy-1 and CD3.J Immunol1988https://conductscience.org/library/papers/2893823PubMed
36,195,289
Precursors of T cell growth factor producing cells in the thymus: ontogeny, frequency, and quantitative recovery in a subpopulation of phenotypically mature thymocytes defined by monoclonal antibody GK-1.5.
J Exp Med1983https://conductscience.org/library/papers/6195289PubMed
46,611,365Differentiation of thymocytes in fetal organ culture: analysis of phenotypic changes accompanying the appearance of cytolytic and interleukin 2-producing cells.J Immunol1984https://conductscience.org/library/papers/6611365PubMed
56,440,796
Detection and localization by the monoclonal anti-interleukin 2 receptor antibody AMT-13 of IL 2 receptor-bearing cells in the developing thymus of the mouse embryo and in the thymus of cortisone-treated mice.
Eur J Immunol1984https://conductscience.org/library/papers/6440796PubMed
62,578,624Unique structure of murine interleukin-2 as deduced from cloned cDNAs.Nature1985https://conductscience.org/library/papers/2578624PubMed
73,919,309Expression and function of interleukin-2 receptors on immature thymocytes.Nature1985https://conductscience.org/library/papers/3919309PubMed
83,921,613Developmentally controlled expression of IL 2 receptors and of sensitivity to IL 2 in a subset of embryonic thymocytes.J Immunol1985https://conductscience.org/library/papers/3921613PubMed
93,921,650Proliferation of thymic stem cells with and without receptors for interleukin 2. Implications for intrathymic antigen recognition.J Exp Med1985https://conductscience.org/library/papers/3921650PubMed
102,859,525Absence of growth by most receptor-expressing fetal thymocytes in the presence of interleukin-2.Nature1985https://conductscience.org/library/papers/2859525PubMed

1 to 10 of 27

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Cited by15

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 74 citations.

PMIDTitleJournalYearIn PapersSource
17,524,378Maternal microchimerism leads to the presence of interleukin-2 in interleukin-2 knock out mice: implications for the role of interleukin-2 in thymic function.Cell Immunol2007https://conductscience.org/library/papers/17524378PubMed
9,479,563Role of gamma delta T cells in immunity to infectious diseases and the regulation of hematolymphoid cell development.Immunol Res1998https://conductscience.org/library/papers/9479563PubMed
8,911,153In vivo expression of interleukin-1 beta (IL-1 beta), IL-2, IL-4, IL-6, tumour necrosis factor-alpha and interferon-gamma in the fetal murine thymus.Immunology1996https://conductscience.org/library/papers/8911153PubMed
8,426,123T cell receptor ligation induces interleukin (IL) 2R beta chain expression in rat CD4,8 double positive thymocytes, initiating an IL-2-dependent differentiation pathway of CD8 alpha+/beta- T cells.J Exp Med1993https://conductscience.org/library/papers/8426123PubMed
8,426,116Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia.J Exp Med1993https://conductscience.org/library/papers/8426116PubMed
7,931,079Positive and negative regulation of the composite octamer motif of the interleukin 2 enhancer by AP-1, Oct-2, and retinoic acid receptor.J Exp Med1994https://conductscience.org/library/papers/7931079PubMed
2,812,004Interleukin-2-dependent autocrine proliferation in T-cell development.Nature1989https://conductscience.org/library/papers/2812004PubMed
2,546,157Diversity in T-cell receptor gamma gene usage in intestinal epithelium.Proc Natl Acad Sci U S A1989https://conductscience.org/library/papers/2546157PubMed
2,373,988A role for interleukin 4 in the differentiation of mature T cell receptor gamma/delta + cells from human intrathymic T cell precursors.J Exp Med1990https://conductscience.org/library/papers/2373988PubMed
2,115,573A model of human cytokine regulation based on transfection of gamma interferon gene fragments directly into isolated peripheral blood T lymphocytes.J Exp Med1990https://conductscience.org/library/papers/2115573PubMed

1 to 10 of 15

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Genes4

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
IFNG3,458PubTator's text mininghttps://conductscience.org/library/genes/3458NCBI Gene
IL23,558PubTator's text mininghttps://conductscience.org/library/genes/3558NCBI Gene
IL2RB3,560PubTator's text mininghttps://conductscience.org/library/genes/3560NCBI Gene
IL43,565PubTator's text mininghttps://conductscience.org/library/genes/3565NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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