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Paper · 3921650

Proliferation of thymic stem cells with and without receptors for interleukin 2. Implications for intrathymic antigen recognition.

Lugo JP and 5 others. J Exp Med, 1985. Cited by 55 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Proliferation of thymic stem cells with and without receptors for interleukin 2. Implications for intrathymic antigen recognition. Papers, record 3921650. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/3921650

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Proliferation of thymic stem cells with and without receptors for interleukin 2. Implications for intrathymic antigen recognition.
PubMed
Journal
J Exp Med
PubMed
Year
1985
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
55
iCite
Relative citation ratio, by iCite
1.09
iCite
Revised in PubMed
2019-05-08
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Lugo JPJ P
2Krishnan SNS N
3Sailor RDR D
4Koen PP
5Malek TT
6Rothenberg EE

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Lymphocyte ActivationMajor topic
Receptors, Antigen, T-CellMajor topic
Receptors, ImmunologicMajor topic
Stem CellsMajor topic
Thymus GlandMajor topic
Animals
Animals, Newborn
Cell Line
Cell Separation
Centrifugation
Female
Lectins
Mice
Mice, Inbred C57BL
Peanut Agglutinin
Phenotype
Receptors, Interleukin-2

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
AI 19752NIAID NIH HHSUnited StatesR01AI019752PubMed and NIHNIH RePORTER
CA 32911NCI NIH HHSUnited StatesP30CA032911PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References36

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
114,978,855The somatic generation of immune recognition.Eur J Immunol1971https://conductscience.org/library/papers/14978855PubMed
26,028,489Thymus cell migration.J Exp Med1967https://conductscience.org/library/papers/6028489PubMed
34,673,318Renewal and fate in the mammalian thymus: mechanisms and inferences of thymocytokinetics.Eur J Immunol1972https://conductscience.org/library/papers/4673318PubMed
4305,459On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?J Exp Med1978https://conductscience.org/library/papers/305459PubMed
5307,765Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.Proc Natl Acad Sci U S A1978https://conductscience.org/library/papers/307765PubMed
6308,986H-2 antigens of the thymus determine lymphocyte specificity.J Exp Med1978https://conductscience.org/library/papers/308986PubMed
7374,246The differentiation of murine thymocytes in vivo and in vitro.Immunology1978https://conductscience.org/library/papers/374246PubMed
8315,985Synthesis and processing of molecules bearing thymus leukemia antigen.J Exp Med1979https://conductscience.org/library/papers/315985PubMed
97,379,836Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice.Eur J Immunol1980https://conductscience.org/library/papers/7379836PubMed
106,966,974Expression of differentiation antigens in subpopulations of mouse thymocytes: regulation at the level of de novo synthesis.Cell1980https://conductscience.org/library/papers/6966974PubMed

1 to 10 of 36

See all 36 references

Cited by9

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 55 citations.

PMIDTitleJournalYearIn PapersSource
3,495,799Interleukin 4 is a growth factor for activated thymocytes: possible role in T-cell ontogeny.Proc Natl Acad Sci U S A1987https://conductscience.org/library/papers/3495799PubMed
3,323,344In vivo proliferation and differentiation of prothymocytes in the thymus.Immunol Res1987https://conductscience.org/library/papers/3323344PubMed
3,134,499T cell receptors of autoimmune mice: functional and molecular analysis of novel T cell subsets in C3H-gld/gld mice.Immunol Res1988https://conductscience.org/library/papers/3134499PubMed
3,129,728Human thymic epithelial cells directly induce activation of autologous immature thymocytes.Proc Natl Acad Sci U S A1988https://conductscience.org/library/papers/3129728PubMed
3,081,905Early precursor thymocytes can produce interleukin 2 upon stimulation with calcium ionophore and phorbol ester.Proc Natl Acad Sci U S A1986https://conductscience.org/library/papers/3081905PubMed
3,049,912A novel activation pathway for mature thymocytes. Costimulation of CD2 (T,p50) and CD28 (T,p44) induces autocrine interleukin 2/interleukin 2 receptor-mediated cell proliferation.J Exp Med1988https://conductscience.org/library/papers/3049912PubMed
2,786,729Effects of interleukin-2 and interferon-alpha A/D treatment on lymphocytes from tumour-bearing mice.Br J Cancer1989https://conductscience.org/library/papers/2786729PubMed
2,497,464Developmental control of lymphokine gene expression in fetal thymocytes during T-cell ontogeny.Proc Natl Acad Sci U S A1989https://conductscience.org/library/papers/2497464PubMed
1,312,665In vitro transfection of fresh thymocytes and T cells shows subset-specific expression of viral promoters.Mol Cell Biol1992https://conductscience.org/library/papers/1312665PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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