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Paper · 27367653

Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses.

Fattori V and 4 others. Molecules, 2016. Cited by 273 papers, by iCite.

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ConductScience Library. Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses. Papers, record 27367653. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/27367653

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses.
PubMed
Journal
Molecules
PubMed
Year
2016
PubMed
Publication types
Journal Article, Review
PubMed
Citations, by iCite
273
iCite
Relative citation ratio, by iCite
13.4
iCite
Revised in PubMed
2024-04-04
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Fattori VVictor
2Hohmann MSMiriam S N
3Rossaneis ACAna C
4Pinho-Ribeiro FAFelipe A
5Verri WAWaldiceu A

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
CapsaicinMajor topic
PainMajor topic
Analgesics
Animals
Capsicum
Clinical Studies as Topic
Drug Compounding
Drug Evaluation, Preclinical
Drug Repositioning
Humans
Nociceptors
Plant Extracts

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References273

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
13,171,675Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture.J Neurosci1988https://conductscience.org/library/papers/3171675PubMed
21,919,668Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia.J Neurophysiol1991https://conductscience.org/library/papers/1919668PubMed
39,415,498A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes.Pain1997https://conductscience.org/library/papers/9415498PubMed
422,327,653Expression of TRPV1 in rabbits and consuming hot pepper affects its body weight.Mol Biol Rep2012https://conductscience.org/library/papers/22327653PubMed
526,775,709Potential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand?Cell Death Dis2016https://conductscience.org/library/papers/26775709PubMed
614,699,077Ca2+/calmodulin modulates TRPV1 activation by capsaicin.J Gen Physiol2004https://conductscience.org/library/papers/14699077PubMed
718,337,008Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans.Pain2008https://conductscience.org/library/papers/18337008PubMed
819,502,594Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner.Carcinogenesis2009https://conductscience.org/library/papers/19502594PubMed
913,129,472Effect of capsaicin on substrate oxidation and weight maintenance after modest body-weight loss in human subjects.Br J Nutr2003https://conductscience.org/library/papers/13129472PubMed
1021,802,026A randomized, double-blind, parallel trial comparing capsaicin nasal spray with placebo in subjects with a significant component of nonallergic rhinitis.Ann Allergy Asthma Immunol2011https://conductscience.org/library/papers/21802026PubMed

1 to 10 of 273

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Cited by175

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 273 citations.

PMIDTitleJournalYearIn PapersSource
42,908,026Capsaicin enhances chemosensitivity and mitigates MMP11-driven aggressiveness in human bladder cancer.Cancer Cell Int2026https://conductscience.org/library/papers/42908026PubMed
42,865,496Patterns of base chromosome numbers, genome size and rDNA loci evolution in the genus Capsicum (Solanaceae).Front Plant Sci2026https://conductscience.org/library/papers/42865496PubMed
42,793,246Long-Term Changes in Chili Pepper Consumption and Inflammatory Biomarkers: A Longitudinal Analysis in the Moli-Sani Study.Curr Issues Mol Biol2026https://conductscience.org/library/papers/42793246PubMed
42,671,722Neuropathic Pain Management Using Novel Biologics in Moderate-to-Severe Hidradenitis Suppurativa.Curr Pain Headache Rep2026https://conductscience.org/library/papers/42671722PubMed
42,611,412Gut-Brain-Skin Axis: From Mechanistic Insights to Translational Applications in Neurocosmetics.Dermatol Ther (Heidelb)2026https://conductscience.org/library/papers/42611412PubMed
42,094,755Regional, multimodal, and opioid-sparing strategies after trauma: a review.Trauma Surg Acute Care Open2026https://conductscience.org/library/papers/42094755PubMed
42,077,900Loading Capsaicin onto Lipid Bilayers: A Molecular Dynamics Study.ACS Omega2026https://conductscience.org/library/papers/42077900PubMed
41,874,158Searching for Mechanisms of Analgesic Activity in the Group of 1H-Pyrrolo[3,4-c]pyridine-1,3(2H)-dione Derivatives-In Vitro and In Vivo Studies.Methods Protoc2026https://conductscience.org/library/papers/41874158PubMed
41,806,222The active plant compounds demonstrated positive activity on mouse intestinal organoids as an inflammation model system.In Vitro Cell Dev Biol Anim2026https://conductscience.org/library/papers/41806222PubMed
41,775,630The Pro- But Not Antinociceptive Effects of Cannabidiol Depend on Trpa1b in Larval Zebrafish.J Neurosci2026https://conductscience.org/library/papers/41775630PubMed

1 to 10 of 175

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Genes35

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
BAK1578PubTator's text mininghttps://conductscience.org/library/genes/578NCBI Gene
BAX581PubTator's text mininghttps://conductscience.org/library/genes/581NCBI Gene
BCL2596PubTator's text mininghttps://conductscience.org/library/genes/596NCBI Gene
CALCA796PubTator's text mininghttps://conductscience.org/library/genes/796NCBI Gene
CALM1801PubTator's text mininghttps://conductscience.org/library/genes/801NCBI Gene
CASP3836PubTator's text mininghttps://conductscience.org/library/genes/836NCBI Gene
CCND1595PubTator's text mininghttps://conductscience.org/library/genes/595NCBI Gene
CDK41,019PubTator's text mininghttps://conductscience.org/library/genes/1019NCBI Gene
CDK61,021PubTator's text mininghttps://conductscience.org/library/genes/1021NCBI Gene
CEBPA1,050PubTator's text mininghttps://conductscience.org/library/genes/1050NCBI Gene

1 to 10 of 35

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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