Paper · 28122245

Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma.

Singh DK and 21 others. Cell Rep, 2017. Cited by 75 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma. Papers, record 28122245. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/28122245

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma.; PubMed
Journal: Cell Rep; PubMed
Year: 2017; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/28122245/; PubMed
DOI: https://doi.org/10.1016/j.celrep.2016.12.064; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC5321610/; PubMed
The journal: https://conductscience.org/library/journal-index/101573691; PubMed
Citations, by iCite: 75; iCite
Relative citation ratio, by iCite: 2.23; iCite
Revised in PubMed: 2022-03-10; PubMed

Authors22

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Singh DK	Dinesh K
2	Kollipara RK	Rahul K
3	Vemireddy V	Vamsidara
4	Yang XL	Xiao-Li
5	Sun Y	Yuxiao
6	Regmi N	Nanda
7	Klingler S	Stefan
8	Hatanpaa KJ	Kimmo J
9	Raisanen J	Jack
10	Cho SK	Steve K

1 to 10 of 22Source PubMed

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Topics24

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Brain Neoplasms	Major topic
Glioblastoma	Major topic
Oligodendrocyte Transcription Factor 2	Major topic
SOXB1 Transcription Factors	Major topic
Zinc Finger E-box-Binding Homeobox 1	Major topic
Animals
Astrocytes
Brain
Cell Proliferation
Cells, Cultured
Disease Models, Animal
Down-Regulation
ErbB Receptors
Gefitinib
Humans
Mice
Mice, Inbred NOD
Mice, SCID
Neoplasm Grading
Plasmids
Plicamycin
Quinazolines
RNA Interference
Receptor, Platelet-Derived Growth Factor alpha

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
P30 CA045508	NCI NIH HHS	United States	P30CA045508	PubMed and NIH	NIH RePORTER
P30 CA142543	NCI NIH HHS	United States	P30CA142543	PubMed and NIH	NIH RePORTER
R01 NS065195	NINDS NIH HHS	United States	R01NS065195	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References40

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	24,552,317	A randomized trial of bevacizumab for newly diagnosed glioblastoma.	N Engl J Med	2014	https://conductscience.org/library/papers/24552317	PubMed
2	16,199,517	Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.	Proc Natl Acad Sci U S A	2005	https://conductscience.org/library/papers/16199517	PubMed
3	18,948,646	SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity.	Stem Cells	2009	https://conductscience.org/library/papers/18948646	PubMed
4	27,105,533	Inhibition of SP1 by the mithramycin analog EC-8042 efficiently targets tumor initiating cells in sarcoma.	Oncotarget	2016	https://conductscience.org/library/papers/27105533	PubMed
5	21,397,859	The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma.	Cancer Cell	2011	https://conductscience.org/library/papers/21397859	PubMed
6	19,398,132	Common astrocytic programs during brain development, injury and cancer.	Trends Neurosci	2009	https://conductscience.org/library/papers/19398132	PubMed
7	17,296,553	Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma.	Neuron	2007	https://conductscience.org/library/papers/17296553	PubMed
8	14,597,658	Cytoscape: a software environment for integrated models of biomolecular interaction networks.	Genome Res	2003	https://conductscience.org/library/papers/14597658	PubMed
9	24,726,434	Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells.	Cell	2014	https://conductscience.org/library/papers/24726434	PubMed
10	23,707,066	An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma.	Cell Rep	2013	https://conductscience.org/library/papers/23707066	PubMed

1 to 10 of 40

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Cited by57

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 75 citations.

PMID	Title	Journal	Year	In Papers	Source
42,205,701	A comprehensive pharmacological survey across heterogeneous patient-derived glioblastoma stem cell models.	iScience	2026	https://conductscience.org/library/papers/42205701	PubMed
41,951,744	Synthetic super-enhancers enable precision viral immunotherapy.	Nature	2026	https://conductscience.org/library/papers/41951744	PubMed
41,002,392	FGFR1 Inhibition by Pemigatinib Enhances Radiosensitivity in Glioblastoma Stem Cells Through S100A4 Downregulation.	Cells	2025	https://conductscience.org/library/papers/41002392	PubMed
40,362,216	p21-Dependent Senescence Induction by BMP4 Renders Glioblastoma Cells Vulnerable to Senolytics.	Int J Mol Sci	2025	https://conductscience.org/library/papers/40362216	PubMed
40,255,400	Single-cell and spatial transcriptomic insights into glioma cellular heterogeneity and metabolic adaptations.	Front Immunol	2025	https://conductscience.org/library/papers/40255400	PubMed
39,752,252	Single-nucleus and spatial landscape of the sub-ventricular zone in human glioblastoma.	Cell Rep	2025	https://conductscience.org/library/papers/39752252	PubMed
39,609,428	Transcription factors ASCL1 and OLIG2 drive glioblastoma initiation and co-regulate tumor cell types and migration.	Nat Commun	2024	https://conductscience.org/library/papers/39609428	PubMed
39,499,086	Modelling quiescence exit of neural stem cells reveals a FOXG1-FOXO6 axis.	Dis Model Mech	2024	https://conductscience.org/library/papers/39499086	PubMed
39,268,037	Differentiation stage-specific expression of transcriptional regulators for epithelial mesenchymal transition in dentate granule progenitors.	Front Neurosci	2024	https://conductscience.org/library/papers/39268037	PubMed
38,268,976	Optical Modulation of the Blood-Brain Barrier for Glioblastoma Treatment.	Bio Protoc	2024	https://conductscience.org/library/papers/38268976	PubMed

1 to 10 of 57

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Genes20

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
DCTN6	10,671	PubTator's text mining	https://conductscience.org/library/genes/10671	NCBI Gene
EGFR	1,956	PubTator's text mining	https://conductscience.org/library/genes/1956	NCBI Gene
ETV1	2,115	PubTator's text mining	https://conductscience.org/library/genes/2115	NCBI Gene
H3P16	644,914	PubTator's text mining	https://conductscience.org/library/genes/644914	NCBI Gene
IDH1	3,417	PubTator's text mining	https://conductscience.org/library/genes/3417	NCBI Gene
MIR200C	406,985	PubTator's text mining	https://conductscience.org/library/genes/406985	NCBI Gene
MIR34A	407,040	PubTator's text mining	https://conductscience.org/library/genes/407040	NCBI Gene
MIR34C	407,042	PubTator's text mining	https://conductscience.org/library/genes/407042	NCBI Gene
NES	10,763	PubTator's text mining	https://conductscience.org/library/genes/10763	NCBI Gene
OLIG1	116,448	PubTator's text mining	https://conductscience.org/library/genes/116448	NCBI Gene

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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