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Paper · 28348166

Mfn2 is critical for brown adipose tissue thermogenic function.

Boutant M and 7 others. EMBO J, 2017. Cited by 239 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Mfn2 is critical for brown adipose tissue thermogenic function. Papers, record 28348166. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/28348166

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Mfn2 is critical for brown adipose tissue thermogenic function.
PubMed
Journal
EMBO J
PubMed
Year
2017
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
239
iCite
Relative citation ratio, by iCite
7.93
iCite
Revised in PubMed
2022-02-22
PubMed

Authors8

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Boutant MMarie
2Kulkarni SSSameer S
3Joffraud MMagali
4Ratajczak JJoanna
5Valera-Alberni MMiriam
6Combe RRoy
7Zorzano AAntoniohttps://orcid.org/0000-0002-1638-0306
8Cantó CCarleshttps://orcid.org/0000-0002-5167-7922

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Adipose Tissue, BrownMajor topic
GTP PhosphohydrolasesMajor topic
MitochondriaMajor topic
ThermogenesisMajor topic
Animals
Mice
Mice, Knockout
Perilipin-1
Protein Binding

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Comment in28,539,389Let's burn whatever you have: mitofusin 2 metabolically re-wires brown adipose tissue.https://conductscience.org/library/papers/28539389

Source PubMed

References56

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
124,899,307The different shades of fat.Nature2014https://conductscience.org/library/papers/24899307PubMed
219,375,517PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores.Biochim Biophys Acta2009https://conductscience.org/library/papers/19375517PubMed
317,693,261Mitochondrial fusion protects against neurodegeneration in the cerebellum.Cell2007https://conductscience.org/library/papers/17693261PubMed
427,554,470Adipose-Specific Deficiency of Fumarate Hydratase in Mice Protects Against Obesity, Hepatic Steatosis, and Insulin Resistance.Diabetes2016https://conductscience.org/library/papers/27554470PubMed
523,029,466Mitofusin-2 independent juxtaposition of endoplasmic reticulum and mitochondria: an ultrastructural study.PLoS One2012https://conductscience.org/library/papers/23029466PubMed
626,734,886Supramolecular Organization of Respiratory Complexes.Annu Rev Physiol2016https://conductscience.org/library/papers/26734886PubMed
721,459,330PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation.Cell Metab2011https://conductscience.org/library/papers/21459330PubMed
821,983,901Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis.EMBO J2011https://conductscience.org/library/papers/21983901PubMed
921,748,599Interactomic study on interaction between lipid droplets and mitochondria.Protein Cell2011https://conductscience.org/library/papers/21748599PubMed
1023,941,871A form of mitofusin 2 (Mfn2) lacking the transmembrane domains and the COOH-terminal end stimulates metabolism in muscle and liver cells.Am J Physiol Endocrinol Metab2013https://conductscience.org/library/papers/23941871PubMed

1 to 10 of 56

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Cited by157

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 239 citations.

PMIDTitleJournalYearIn PapersSource
42,935,206[Research progress on mitochondria-lipid droplet coupling and its regulation of lipid metabolism and obesity].Zhong Nan Da Xue Xue Bao Yi Xue Ban2026https://conductscience.org/library/papers/42935206PubMed
42,897,134Mitophagy coordinates organelle crosstalk in health and diseases.Signal Transduct Target Ther2026https://conductscience.org/library/papers/42897134PubMed
42,886,804MFN2-associated astrocyte dysfunction contributes to neuronal hyperexcitability and depressive-like behaviors.Sci Adv2026https://conductscience.org/library/papers/42886804PubMed
42,568,782Loss of Rab8a-Dependent Tethering of Lipid Droplets to Mitochondria Contributes to Hypoxia-Reoxygenation Injury.MedComm (2020)2026https://conductscience.org/library/papers/42568782PubMed
42,521,674Mitochondrial quality control in health and disease: mechanisms and therapeutic targets.Signal Transduct Target Ther2026https://conductscience.org/library/papers/42521674PubMed
42,393,720Crosstalk collapse: mitochondria-centric organelle network disruption in ovarian aging.Cell Commun Signal2026https://conductscience.org/library/papers/42393720PubMed
42,348,442Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity.Adv Sci (Weinh)2026https://conductscience.org/library/papers/42348442PubMed
41,935,069Organelle contact sites in cancer cells.Cell Death Dis2026https://conductscience.org/library/papers/41935069PubMed
41,918,627Lipid droplet dynamics in metabolic regulation.RSC Chem Biol2026https://conductscience.org/library/papers/41918627PubMed
41,888,809Mitochondrial interplay with membrane organelles in health and disease.Cell Commun Signal2026https://conductscience.org/library/papers/41888809PubMed

1 to 10 of 157

See all 157 cited by

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
INS3,630PubTator's text mininghttps://conductscience.org/library/genes/3630NCBI Gene
MFN29,927PubTator's text mininghttps://conductscience.org/library/genes/9927NCBI Gene
PLIN15,346PubTator's text mininghttps://conductscience.org/library/genes/5346NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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