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Paper · 28530655

A quantitative and multiplexed approach to uncover the fitness landscape of tumor suppression in vivo.

Rogers ZN and 6 others. Nat Methods, 2017. Cited by 113 papers, by iCite.

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ConductScience Library. A quantitative and multiplexed approach to uncover the fitness landscape of tumor suppression in vivo. Papers, record 28530655. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/28530655

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
A quantitative and multiplexed approach to uncover the fitness landscape of tumor suppression in vivo.
PubMed
Journal
Nat Methods
PubMed
Year
2017
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
113
iCite
Relative citation ratio, by iCite
2.5
iCite
Revised in PubMed
2018-11-13
PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Rogers ZNZoë N
2McFarland CDChristopher D
3Winters IPIan Phttps://orcid.org/0000-0002-3497-3228
4Naranjo SSantiago
5Chuang CHChen-Hua
6Petrov DDmitri
7Winslow MMMonte M

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Neoplasms, ExperimentalMajor topic
Tumor Suppressor ProteinsMajor topic
Adenocarcinoma
Animals
DNA
DNA Barcoding, Taxonomic
Female
Genetic Engineering
Humans
Lentivirus
Lung
Lung Neoplasms
Male
Mice
Models, Genetic
Plasmids
Proto-Oncogene Proteins p21(ras)

Source PubMed

Grants8

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R25 CA180993NCI NIH HHSUnited StatesR25CA180993PubMed and NIHNIH RePORTER
R01 CA175336NCI NIH HHSUnited StatesR01CA175336PubMed and NIHNIH RePORTER
R01 CA207133NCI NIH HHSUnited StatesR01CA207133PubMed and NIHNIH RePORTER
T32 HG000044NHGRI NIH HHSUnited StatesT32HG000044PubMed and NIHNIH RePORTER
R35 GM118165NIGMS NIH HHSUnited StatesR35GM118165PubMed and NIHNIH RePORTER
R21 CA194910NCI NIH HHSUnited StatesR21CA194910PubMed and NIHNIH RePORTER
S10 OD018220NIH HHSUnited StatesS10OD018220PubMed and NIHNIH RePORTER
P30 CA124435NCI NIH HHSUnited StatesP30CA124435PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Comment in28,607,511Technique: Sizing up tumours with Tuba-seq.https://conductscience.org/library/papers/28607511

Source PubMed

References54

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
116,288,016The differential effects of mutant p53 alleles on advanced murine lung cancer.Cancer Res2005https://conductscience.org/library/papers/16288016PubMed
222,980,975Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing.Cell2012https://conductscience.org/library/papers/22980975PubMed
311,751,630Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras.Genes Dev2001https://conductscience.org/library/papers/11751630PubMed
426,853,560Tumor suppressor properties of the splicing regulatory factor RBM10.RNA Biol2016https://conductscience.org/library/papers/26853560PubMed
519,270,154Tumor suppressors and cell metabolism: a recipe for cancer growth.Genes Dev2009https://conductscience.org/library/papers/19270154PubMed
611,694,875Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.Nat Genet2001https://conductscience.org/library/papers/11694875PubMed
73,191,483A Gompertzian model of human breast cancer growth.Cancer Res1988https://conductscience.org/library/papers/3191483PubMed
821,385,881Hypoxia and senescence: the impact of oxygenation on tumor suppression.Mol Cancer Res2011https://conductscience.org/library/papers/21385881PubMed
917,676,052A spatially and temporally restricted mouse model of soft tissue sarcoma.Nat Med2007https://conductscience.org/library/papers/17676052PubMed
1025,765,070Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer.Science2015https://conductscience.org/library/papers/25765070PubMed

1 to 10 of 54

See all 54 references

Cited by100

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 113 citations.

PMIDTitleJournalYearIn PapersSource
42,875,424Antagonistic roles of histone H3 lysine methyltransferases dictate tumor immune surveillance.Nat Commun2026https://conductscience.org/library/papers/42875424PubMed
42,818,943Quantitative dissection of the metastatic cascade at single colony resolution.Res Sq2026https://conductscience.org/library/papers/42818943PubMed
42,298,891Inducible CRISPR/Cas systems in precision oncology: Current applications and future perspectives.Clin Transl Med2026https://conductscience.org/library/papers/42298891PubMed
42,297,823Tumor suppressor genotype influences the extent and mode of immunosurveillance in lung cancer.Nat Commun2026https://conductscience.org/library/papers/42297823PubMed
42,225,068Temporal control of sgRNA library activation unlocks large-scale in vivo CRISPR screens.Cell Rep Methods2026https://conductscience.org/library/papers/42225068PubMed
42,124,569Quantitative dissection of the metastatic cascade at single colony resolution.bioRxiv2026https://conductscience.org/library/papers/42124569PubMed
41,758,887Putting BASIL in a BLT: A Bayesian filtering method for estimating the fitness effects of nascent adaptive mutations.PLoS Comput Biol2026https://conductscience.org/library/papers/41758887PubMed
41,705,258In vivo multiplexed modeling reveals diverse roles of the TBX2 subfamily and Egr1 in Kr as-driven lung adenocarcinoma.Genes Dis2026https://conductscience.org/library/papers/41705258PubMed
41,648,157Scaling perturbations: beyond genome-scale CRISPR screens.bioRxiv2026https://conductscience.org/library/papers/41648157PubMed
41,188,600Aging represses oncogenic KRAS-driven lung tumorigenesis and alters tumor suppression.Nat Aging2025https://conductscience.org/library/papers/41188600PubMed

1 to 10 of 100

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Genes8

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ARID1A8,289PubTator's text mininghttps://conductscience.org/library/genes/8289NCBI Gene
ATM472PubTator's text mininghttps://conductscience.org/library/genes/472NCBI Gene
DNMBP23,268PubTator's text mininghttps://conductscience.org/library/genes/23268NCBI Gene
KEAP19,817PubTator's text mininghttps://conductscience.org/library/genes/9817NCBI Gene
KRAS3,845PubTator's text mininghttps://conductscience.org/library/genes/3845NCBI Gene
RBM108,241PubTator's text mininghttps://conductscience.org/library/genes/8241NCBI Gene
SETD229,072PubTator's text mininghttps://conductscience.org/library/genes/29072NCBI Gene
SMAD44,089PubTator's text mininghttps://conductscience.org/library/genes/4089NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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