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Paper · 29485237

Recent progress in Lynch syndrome and other familial colorectal cancer syndromes.

Boland PM and 2 others. CA Cancer J Clin, 2018. Cited by 130 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Recent progress in Lynch syndrome and other familial colorectal cancer syndromes. Papers, record 29485237. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/29485237

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Recent progress in Lynch syndrome and other familial colorectal cancer syndromes.
PubMed
Journal
CA Cancer J Clin
PubMed
Year
2018
PubMed
Publication types
Journal Article, Review
PubMed
Citations, by iCite
130
iCite
Relative citation ratio, by iCite
4.32
iCite
Revised in PubMed
2024-03-18
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Boland PMPatrick M
2Yurgelun MBMatthew B
3Boland CRC Richardhttps://orcid.org/0000-0002-8120-5088

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Colorectal Neoplasms, Hereditary NonpolyposisMajor topic
Adenoma
Cell Transformation, Neoplastic
Chemoprevention
Chemotherapy, Adjuvant
Colectomy
Colonoscopy
Colorectal Neoplasms
DNA Mutational Analysis
Genetic Testing
Germ-Line Mutation
Humans
Sequence Analysis, DNA

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
R01 CA072851NCI NIH HHSUnited StatesR01CA072851PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References155

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
127,806,234Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway.N Engl J Med2016https://conductscience.org/library/papers/27806234PubMed
28,690,794Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine.J Clin Invest1996https://conductscience.org/library/papers/8690794PubMed
322,262,812Microsatellite instability and DNA mismatch repair protein deficiency in Lynch syndrome colorectal polyps.Cancer Prev Res (Phila)2012https://conductscience.org/library/papers/22262812PubMed
427,556,954Universal Screening for Mismatch-Repair Deficiency in Endometrial Cancers to Identify Patients With Lynch Syndrome and Lynch-like Syndrome.Int J Gynecol Pathol2017https://conductscience.org/library/papers/27556954PubMed
525,139,339Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: a pooled analysis of the CAIRO, CAIRO2, COIN, and FOCUS studies.Clin Cancer Res2014https://conductscience.org/library/papers/25139339PubMed
619,503,063Tumor-infiltrating lymphocytes in colorectal cancers with microsatellite instability are correlated with the number and spectrum of frameshift mutations.Mod Pathol2009https://conductscience.org/library/papers/19503063PubMed
725,345,868Mismatch repair genes founder mutations and cancer susceptibility in Lynch syndrome.Clin Genet2015https://conductscience.org/library/papers/25345868PubMed
817,373,663Beta2-microglobulin mutations in microsatellite unstable colorectal tumors.Int J Cancer2007https://conductscience.org/library/papers/17373663PubMed
99,618,505Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma.Proc Natl Acad Sci U S A1998https://conductscience.org/library/papers/9618505PubMed
1026,582,061Comparison of Prediction Models for Lynch Syndrome Among Individuals With Colorectal Cancer.J Natl Cancer Inst2016https://conductscience.org/library/papers/26582061PubMed

1 to 10 of 155

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Cited by94

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 130 citations.

PMIDTitleJournalYearIn PapersSource
42,841,377Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer.Mol Oncol2026https://conductscience.org/library/papers/42841377PubMed
42,266,697Tracing the stemness and malignant transition in a heritable colorectal cancer Lynch Syndrome by single-cell RNA-seq analysis.Front Immunol2026https://conductscience.org/library/papers/42266697PubMed
41,987,791A novel frameshift variant in MSH2 (p.Q170Rfs4) associated with suspected Lynch syndrome in a Chinese family.Front Med (Lausanne)2026https://conductscience.org/library/papers/41987791PubMed
41,943,138Targeted hyperthermia therapy (THT) using gold nanorods remodels the tumor microenvironment to sensitize murine microsatellite-stable colorectal cancer to immune checkpoint blockade.J Nanobiotechnology2026https://conductscience.org/library/papers/41943138PubMed
41,846,284Molecular Profiling of Germline Variants in the DNA Mismatch Repair Genes in Chinese Colorectal Cancer Patients.Genet Res (Camb)2026https://conductscience.org/library/papers/41846284PubMed
41,840,625Bifidobacterium breve inhibits colorectal cancer via extracellular vesicles containing formate acetyltransferase.J Nanobiotechnology2026https://conductscience.org/library/papers/41840625PubMed
41,681,978Lynch Syndrome as a Spectrum of Four Distinct Genetic Disorders: Toward Genotype-Guided Precision Management in the NGS Era.Cancers (Basel)2026https://conductscience.org/library/papers/41681978PubMed
41,563,663Research progress in diagnosis and treatment of pancreatic cancer with mismatch repair and microsatellite instability.Clin Transl Oncol2026https://conductscience.org/library/papers/41563663PubMed
41,523,913RNA-Seq of Cultured Peripheral Blood Lymphocytes Improves Identification of Cryptic Splicing Defects in Rare Disease Diagnostics.Hum Mutat2026https://conductscience.org/library/papers/41523913PubMed
41,497,507Incidence of non-colorectal/endometrial malignancies in individuals with Lynch syndrome: a retrospective cohort study.EClinicalMedicine2025https://conductscience.org/library/papers/41497507PubMed

1 to 10 of 94

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Genes39

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
APC324PubTator's text mininghttps://conductscience.org/library/genes/324NCBI Gene
ATM472PubTator's text mininghttps://conductscience.org/library/genes/472NCBI Gene
B2M567PubTator's text mininghttps://conductscience.org/library/genes/567NCBI Gene
BAX581PubTator's text mininghttps://conductscience.org/library/genes/581NCBI Gene
BRAF673PubTator's text mininghttps://conductscience.org/library/genes/673NCBI Gene
BRCA1672PubTator's text mininghttps://conductscience.org/library/genes/672NCBI Gene
BRCA2675PubTator's text mininghttps://conductscience.org/library/genes/675NCBI Gene
CD27429,126PubTator's text mininghttps://conductscience.org/library/genes/29126NCBI Gene
CD8A925PubTator's text mininghttps://conductscience.org/library/genes/925NCBI Gene
CDKN2A1,029PubTator's text mininghttps://conductscience.org/library/genes/1029NCBI Gene

1 to 10 of 39

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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