Paper3036070
Complete amino acid sequence of the A chain of human complement-classical-pathway enzyme C1r.
Arlaud GJ and 2 others. Biochem J, 1987. Cited by 51 papers, by iCite.
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ConductScience Library. Complete amino acid sequence of the A chain of human complement-classical-pathway enzyme C1r. Papers, record 3036070. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/3036070
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- Complete amino acid sequence of the A chain of human complement-classical-pathway enzyme C1r.
- PubMed
Topics7
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Complement Activating Enzymes | Major topic |
| Complement C1 | Major topic |
| Amino Acid Sequence | |
| Amino Acids | |
| Complement C1r | |
| Humans | |
| Peptide Fragments |
Source PubMed
References28
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 869,924 | The structure and enzymic activities of the C1r and C1s subcomponents of C1, the first component of human serum complement. | Biochem J | 1977 | https://conductscience.org/library/papers/869924 | PubMed |
| 2 | 13,753,215 | beta-Hydroxyaspartic acid: synthesis and separation of its diastereoisomers. | Arch Biochem Biophys | 1960 | https://conductscience.org/library/papers/13753215 | PubMed |
| 3 | 40,870 | Differential elution of Clq, Clr and Cls from human Cl bound to immune aggregates. Use in the rapid purification of Cl subcomponents. | Mol Immunol | 1979 | https://conductscience.org/library/papers/40870 | PubMed |
| 4 | 6,250,896 | Calcium binding properties of the C1 subcomponents C1q, C1r and C1s. | FEBS Lett | 1980 | https://conductscience.org/library/papers/6250896 | PubMed |
| 5 | 6,254,570 | Purified proenzyme C1r. Some characteristics of its activation and subsequent proteolytic cleavage. | Biochim Biophys Acta | 1980 | https://conductscience.org/library/papers/6254570 | PubMed |
| 6 | 7,023,363 | The proteolytic activation systems of complement. | Annu Rev Biochem | 1981 | https://conductscience.org/library/papers/7023363 | PubMed |
| 7 | 6,281,620 | The human complement system serine proteases C1r and C1s and their proenzymes. | Methods Enzymol | 1981 | https://conductscience.org/library/papers/6281620 | PubMed |
| 8 | 6,282,261 | The catalytic chain of human complement subcomponent C1r. Purification and N-terminal amino acid sequences of the major cyanogen bromide-cleavage fragments. | Biochem J | 1982 | https://conductscience.org/library/papers/6282261 | PubMed |
| 9 | 7,092,811 | Isolation, characterization and N-terminal sequences of the CNBr-cleavage peptides from human complement Factor B. Localization of a free thiol group and a sequence defining the site cleaved by factor D. | Biochem J | 1982 | https://conductscience.org/library/papers/7092811 | PubMed |
| 10 | 6,572,939 | beta-Hydroxyaspartic acid in vitamin K-dependent protein C. | Proc Natl Acad Sci U S A | 1983 | https://conductscience.org/library/papers/6572939 | PubMed |
| 11 | 6,303,394 | Complete amino acid sequence of the catalytic chain of human complement subcomponent C1-r. | Biochemistry | 1983 | https://conductscience.org/library/papers/6303394 | PubMed |
| 12 | 6,871,167 | Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as beta-hydroxyaspartic acid. | Biochemistry | 1983 | https://conductscience.org/library/papers/6871167 | PubMed |
| 13 | 6,688,526 | The occurrence of beta-hydroxyaspartic acid in the vitamin K-dependent blood coagulation zymogens. | Biochem Biophys Res Commun | 1983 | https://conductscience.org/library/papers/6688526 | PubMed |
| 14 | 6,630,196 | Beta-hydroxyaspartic acid in vitamin K-dependent proteins. | J Biol Chem | 1983 | https://conductscience.org/library/papers/6630196 | PubMed |
| 15 | 6,692,907 | erythro-beta-Hydroxyaspartic acid in bovine factor IX and factor X. | FEBS Lett | 1984 | https://conductscience.org/library/papers/6692907 | PubMed |
| 16 | 6,425,296 | Derivatives of blood coagulation factor IX contain a high affinity Ca2+-binding site that lacks gamma-carboxyglutamic acid. | J Biol Chem | 1984 | https://conductscience.org/library/papers/6425296 | PubMed |
| 17 | 6,546,930 | Calcium-binding properties of bovine factor X lacking the gamma-carboxyglutamic acid-containing region. | J Biol Chem | 1984 | https://conductscience.org/library/papers/6546930 | PubMed |
| 18 | 6,329,734 | The gene structure of human anti-haemophilic factor IX. | EMBO J | 1984 | https://conductscience.org/library/papers/6329734 | PubMed |
| 19 | 6,091,100 | Cloning and sequencing of liver cDNA coding for bovine protein C. | Proc Natl Acad Sci U S A | 1984 | https://conductscience.org/library/papers/6091100 | PubMed |
| 20 | 6,149,573 | Activation of C1. | Philos Trans R Soc Lond B Biol Sci | 1984 | https://conductscience.org/library/papers/6149573 | PubMed |
Cited by10
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 51 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 31,749,804 | C1R Mutations Trigger Constitutive Complement 1 Activation in Periodontal Ehlers-Danlos Syndrome. | Front Immunol | 2019 | https://conductscience.org/library/papers/31749804 | PubMed |
| 15,527,420 | A novel human complement-related protein, C1r-like protease (C1r-LP), specifically cleaves pro-C1s. | Biochem J | 2005 | https://conductscience.org/library/papers/15527420 | PubMed |
| 11,823,416 | The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex. | EMBO J | 2002 | https://conductscience.org/library/papers/11823416 | PubMed |
| 8,136,028 | Chemical characterization and location of ionic interactions involved in the assembly of the C1 complex of human complement. | J Protein Chem | 1993 | https://conductscience.org/library/papers/8136028 | PubMed |
| 3,262,057 | The role of beta-hydroxyaspartate and adjacent carboxylate residues in the first EGF domain of human factor IX. | EMBO J | 1988 | https://conductscience.org/library/papers/3262057 | PubMed |
| 2,954,545 | Characterization of primary amino acid sequence of human complement control protein factor I from an analysis of cDNA clones. | Biochem J | 1987 | https://conductscience.org/library/papers/2954545 | PubMed |
| 2,825,166 | Occurrence of beta-hydroxylated asparagine residues in non-vitamin K-dependent proteins containing epidermal growth factor-like domains. | Proc Natl Acad Sci U S A | 1987 | https://conductscience.org/library/papers/2825166 | PubMed |
| 2,556,995 | The quaternary structure in solution of human complement subcomponent C1r2C1s2. | Biochem J | 1989 | https://conductscience.org/library/papers/2556995 | PubMed |
| 2,539,098 | Isolation and functional characterization of the proenzyme form of the catalytic domains of human C1r. | Biochem J | 1989 | https://conductscience.org/library/papers/2539098 | PubMed |
| 2,535,773 | Genetic studies of low-abundance human plasma proteins. XIII. Population genetics of C1R complement subcomponent and description of new variants. | Am J Hum Genet | 1989 | https://conductscience.org/library/papers/2535773 | PubMed |
Genes3
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| C1R | 715 | Swiss-Prot's references | https://conductscience.org/library/genes/715 | NCBI Gene |
| F9 | 2,158 | PubTator's text mining | https://conductscience.org/library/genes/2158 | NCBI Gene |
| PROC | 5,624 | PubTator's text mining | https://conductscience.org/library/genes/5624 | NCBI Gene |
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
None in this release
- Grants
- Trials
- Comments and corrections
- Drugs
- Data
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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