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Paper · 30833752

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.

Bryant KL and 30 others. Nat Med, 2019. Cited by 582 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer. Papers, record 30833752. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/30833752

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.
PubMed
Journal
Nat Med
PubMed
Year
2019
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.
PubMed
Citations, by iCite
582
iCite
Relative citation ratio, by iCite
21.1
iCite
Revised in PubMed
2026-11-02
PubMed

Authors31

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Bryant KLKirsten Lhttps://orcid.org/0000-0003-4026-0942
2Stalnecker CAClint Ahttps://orcid.org/0000-0002-0570-4416
3Zeitouni DDaniel
4Klomp JEJennifer E
5Peng SSen
6Tikunov APAndrey P
7Gunda VVenugopal
8Pierobon MMariaelena
9Waters AMAndrew Mhttps://orcid.org/0000-0002-6058-5878
10George SDSamuel D

1 to 10 of 31Source PubMed

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Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AutophagyMajor topic
ChloroquineMajor topic
MAP Kinase Signaling SystemMajor topic
Pancreatic NeoplasmsMajor topic
Protein Kinase InhibitorsMajor topic
Animals
Cell Line, Tumor
Cell Proliferation
Drug Synergism
HEK293 Cells
Humans
Mice
Mitochondria
Mutation
Proto-Oncogene Proteins p21(ras)

Source PubMed

Grants17

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 CA042978NCI NIH HHSUnited StatesR01CA042978PubMed and NIHNIH RePORTER
T32 CA009156NCI NIH HHSUnited StatesT32CA009156PubMed and NIHNIH RePORTER
F32 CA232529NCI NIH HHSUnited StatesF32CA232529PubMed and NIHNIH RePORTER
R01 CA157490NCI NIH HHSUnited StatesR01CA157490PubMed and NIHNIH RePORTER
T32 CA071341NCI NIH HHSUnited StatesT32CA071341PubMed and NIHNIH RePORTER
R01 CA188048NCI NIH HHSUnited StatesR01CA188048PubMed and NIHNIH RePORTER
P30 ES010126NIEHS NIH HHSUnited StatesP30ES010126PubMed and NIHNIH RePORTER
P30 CA016672NCI NIH HHSUnited StatesP30CA016672PubMed and NIHNIH RePORTER
P01 CA203657NCI NIH HHSUnited StatesP01CA203657PubMed and NIHNIH RePORTER
R35 CA232113NCI NIH HHSUnited StatesR35CA232113PubMed and NIHNIH RePORTER

1 to 10 of 17

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Trials1

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's record
NCT02704156SBRT Plus Pembrolizumab and Trametinib for Pancreatic CancerBackground

Source ClinicalTrials.gov

Comments and corrections6

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn PapersSource
Erratum in32,483,362Author Correction: Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.https://conductscience.org/library/papers/32483362PubMed
Comment in30,890,533Combo Drug Strategy Tested for PDAC.https://conductscience.org/library/papers/30890533PubMed
Comment in30,890,815Autophagy inhibitor combination strategies for pancreatic cancer.https://conductscience.org/library/papers/30890815PubMed
Comment in30,914,805Blocking autophagy to starve pancreatic cancer.https://conductscience.org/library/papers/30914805PubMed
Comment in30,936,466Eliminating protective autophagy in KRAS-mutant cancers.https://conductscience.org/library/papers/30936466PubMed
Comment in31,208,693Dual Targeting of Autophagy and MEK in KRAS Mutant Cancer.https://conductscience.org/library/papers/31208693PubMed

References60

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
124,115,766Exploiting the bad eating habits of Ras-driven cancers.Genes Dev2013https://conductscience.org/library/papers/24115766PubMed
221,127,245Autophagy and metabolism.Science2010https://conductscience.org/library/papers/21127245PubMed
322,081,344Antibody validation by Western blotting.Methods Mol Biol2012https://conductscience.org/library/papers/22081344PubMed
426,725,216Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression.Cancer Cell2016https://conductscience.org/library/papers/26725216PubMed
528,446,508Enrichment of PI3K-AKT-mTOR Pathway Activation in Hepatic Metastases from Breast Cancer.Clin Cancer Res2017https://conductscience.org/library/papers/28446508PubMed
629,467,321Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors.JCI Insight2018https://conductscience.org/library/papers/29467321PubMed
730,833,748Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers.Nat Med2019https://conductscience.org/library/papers/30833748PubMed
825,833,948Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy.J Biol Chem2015https://conductscience.org/library/papers/25833948PubMed
926,732,095Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120.Cancer Discov2016https://conductscience.org/library/papers/26732095PubMed
1021,406,549Pancreatic cancers require autophagy for tumor growth.Genes Dev2011https://conductscience.org/library/papers/21406549PubMed

1 to 10 of 60

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Cited by441

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 582 citations.

PMIDTitleJournalYearIn PapersSource
42,963,543KRAS in pancreatic cancer: from molecular biology to transformative therapeutics.J Hematol Oncol2026https://conductscience.org/library/papers/42963543PubMed
42,948,742Prediction of therapeutic targets and drug candidates for pancreatic ductal adenocarcinoma by network-based computational framework.Chin Herb Med2026https://conductscience.org/library/papers/42948742PubMed
42,893,987A lipoprotein-biomimetic nanoplatform for oncogenic KRAS mutation-specific lysosome-targeting protein degradation.Nat Commun2026https://conductscience.org/library/papers/42893987PubMed
42,888,392Transcriptomic profiling reveals autophagy-associated programs and prognostic biomarkers in anoikis-resistant pancreatic cancer cells.BMC Cancer2026https://conductscience.org/library/papers/42888392PubMed
42,848,794ZBED6 deficiency drives pathological cardiac hypertrophy through MEOX1-ERK1/2-dependent autophagy dysfunction.PLoS Genet2026https://conductscience.org/library/papers/42848794PubMed
42,814,831Remodeling of mitochondrial dynamics by metabolic pathways couples to oncogenic growth in GNAS (Gαs) mutant pancreas cancer.Sci Adv2026https://conductscience.org/library/papers/42814831PubMed
42,794,917
Mechanisms of Resistance to MEK Inhibitors (RAS-MAPK Pathway) in Malignant Peripheral Nerve Sheath Tumors and Their Precursor Lesions (Plexiform Neurofibromas) Associated with Neurofibromatosis Type 1.
Cancers (Basel)2026https://conductscience.org/library/papers/42794917PubMed
42,717,493Mutant KRAS-m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target.Adv Sci (Weinh)2026https://conductscience.org/library/papers/42717493PubMed
42,666,728Autophagy inhibition in pancreatic cancer: hope or hype?Autophagy Rep2026https://conductscience.org/library/papers/42666728PubMed
42,627,658Autophagy Orchestrates Anti-Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP-2 Axis in Colorectal Cancer.Adv Sci (Weinh)2026https://conductscience.org/library/papers/42627658PubMed

1 to 10 of 441

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Genes39

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ACTB60PubTator's text mininghttps://conductscience.org/library/genes/60NCBI Gene
ANXA5308PubTator's text mininghttps://conductscience.org/library/genes/308NCBI Gene
ATG59,474PubTator's text mininghttps://conductscience.org/library/genes/9474NCBI Gene
ATG710,533PubTator's text mininghttps://conductscience.org/library/genes/10533NCBI Gene
BBC327,113PubTator's text mininghttps://conductscience.org/library/genes/27113NCBI Gene
BCL2L1110,018PubTator's text mininghttps://conductscience.org/library/genes/10018NCBI Gene
BECN18,678PubTator's text mininghttps://conductscience.org/library/genes/8678NCBI Gene
BRAF673PubTator's text mininghttps://conductscience.org/library/genes/673NCBI Gene
CASP7840PubTator's text mininghttps://conductscience.org/library/genes/840NCBI Gene
COL11A21,302PubTator's text mininghttps://conductscience.org/library/genes/1302NCBI Gene

1 to 10 of 39

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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