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Paper33859647

High-Oxygen Submersion Fetal Thymus Organ Cultures Enable FOXN1-Dependent and -Independent Support of T Lymphopoiesis.

Han J and 1 other. Front Immunol, 2021. Cited by 13 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. High-Oxygen Submersion Fetal Thymus Organ Cultures Enable FOXN1-Dependent and -Independent Support of T Lymphopoiesis. Papers, record 33859647. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/33859647

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
High-Oxygen Submersion Fetal Thymus Organ Cultures Enable FOXN1-Dependent and -Independent Support of T Lymphopoiesis.
PubMed
Journal
Front Immunol
PubMed
Year
2021
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
13
iCite
Relative citation ratio, by iCite
0.6
iCite
Revised in PubMed
2021-09-28
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Han JJianxun
2Zúñiga-Pflücker JCJuan Carlos

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Forkhead Transcription FactorsMajor topic
LymphopoiesisMajor topic
Organ Culture TechniquesMajor topic
OxygenMajor topic
ThymocytesMajor topic
Thymus GlandMajor topic
Animals
Biomarkers
Cell Differentiation
Immunophenotyping
Mice
T-Lymphocyte Subsets

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
FND-154332CIHRCanadaPubMed

Source PubMed

References36

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
124,748,636An overview of the intrathymic intricacies of T cell development.J Immunol2014https://conductscience.org/library/papers/24748636PubMed
222,778,389Thymus-autonomous T cell development in the absence of progenitor import.J Exp Med2012https://conductscience.org/library/papers/22778389PubMed
316,056,227Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism.Nat Immunol2005https://conductscience.org/library/papers/16056227PubMed
4374,246The differentiation of murine thymocytes in vivo and in vitro.Immunology1978https://conductscience.org/library/papers/374246PubMed
511,602,643Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow.J Exp Med2001https://conductscience.org/library/papers/11602643PubMed
62,787,360Effect of IL-7 on the growth of fetal thymocytes in culture.J Immunol1989https://conductscience.org/library/papers/2787360PubMed
730,038,304Fundamental parameters of the developing thymic epithelium in the mouse.Sci Rep2018https://conductscience.org/library/papers/30038304PubMed
822,851,642Self-renewal of thymocytes in the absence of competitive precursor replenishment.J Exp Med2012https://conductscience.org/library/papers/22851642PubMed
929,032,224Limitations of oxygen delivery to cells in culture: An underappreciated problem in basic and translational research.Free Radic Biol Med2017https://conductscience.org/library/papers/29032224PubMed
1015,784,609Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction.Nucleic Acids Res2005https://conductscience.org/library/papers/15784609PubMed
1126,257,169Metabolic Damage and Premature Thymus Aging Caused by Stromal Catalase Deficiency.Cell Rep2015https://conductscience.org/library/papers/26257169PubMed
127,552,996Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo.Immunity1995https://conductscience.org/library/papers/7552996PubMed
137,831,294Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.Proc Natl Acad Sci U S A1995https://conductscience.org/library/papers/7831294PubMed
142,785,551Mouse fetal thymus lobes cultured in IL-2 generate CD3+, TCR-gamma delta-expressing CD4-/CD8+ and CD4-/CD8- cells.J Immunol1989https://conductscience.org/library/papers/2785551PubMed
1526,538,393Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus.J Immunol2015https://conductscience.org/library/papers/26538393PubMed
1627,548,434Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells.Nat Immunol2016https://conductscience.org/library/papers/27548434PubMed
177,964,471Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.J Exp Med1994https://conductscience.org/library/papers/7964471PubMed
1817,251,932Restoration of p53 function leads to tumour regression in vivo.Nature2007https://conductscience.org/library/papers/17251932PubMed
1913,795,076Morphogenetic interactions in the development of the mouse thymus gland.Dev Biol1960https://conductscience.org/library/papers/13795076PubMed
2016,393,955Three-dimensional architecture of the thymus is required to maintain delta-like expression necessary for inducing T cell development.J Immunol2006https://conductscience.org/library/papers/16393955PubMed

See all 36 references

Cited by12

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 13 citations.

PMIDTitleJournalYearIn PapersSource
42,841,477Heterogeneity and ontogeny of mouse thymic macrophages reveal a requirement for Csf1r-expressing myeloid cells during early T cell development.Elife2026https://conductscience.org/library/papers/42841477PubMed
42,111,706Generation of Functional Patient-Specific Thymus Organoids From Human Pluripotent Stem Cells (hPSCs) Using Air-Liquid Interface Culture.Bio Protoc2026https://conductscience.org/library/papers/42111706PubMed
41,693,238The Thymus Regeneration Paradox: The Search for Stemness in an Involuting Organ.Immunol Rev2026https://conductscience.org/library/papers/41693238PubMed
41,483,809Hematopoietic organoids: Opportunities and challenges in modeling human hematopoiesis and diseases in vitro.Stem Cell Reports2026https://conductscience.org/library/papers/41483809PubMed
41,366,437The cellular senescence-metabolism axis: emerging insights into T cell dynamics in the context of biological aging.Cell Commun Signal2025https://conductscience.org/library/papers/41366437PubMed
39,042,204Thymic microenvironment's impact on immunosenescence.Immunol Res2024https://conductscience.org/library/papers/39042204PubMed
39,040,069Vhl safeguards thymic epithelial cell identity and thymopoietic capacity by constraining Hif1a activity during development.iScience2024https://conductscience.org/library/papers/39040069PubMed
38,919,014Challenges and innovations in hematopoietic stem cell transplantation: exploring bone marrow niches and new model systems.BMB Rep2024https://conductscience.org/library/papers/38919014PubMed
37,559,721Thymic epithelial cell fate and potency in early organogenesis assessed by single cell transcriptional and functional analysis.Front Immunol2023https://conductscience.org/library/papers/37559721PubMed
37,202,105Progress on methods of T lymphocyte development in vitro.Zhejiang Da Xue Xue Bao Yi Xue Ban2022https://conductscience.org/library/papers/37202105PubMed
36,963,390Generation of functional thymic organoids from human pluripotent stem cells.Stem Cell Reports2023https://conductscience.org/library/papers/36963390PubMed
36,374,465Fetal Thymic Organ Culture and Negative Selection.Methods Mol Biol2023https://conductscience.org/library/papers/36374465PubMed

Genes7

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CCL256,370PubTator's text mininghttps://conductscience.org/library/genes/6370NCBI Gene
CD4920PubTator's text mininghttps://conductscience.org/library/genes/920NCBI Gene
CD44960PubTator's text mininghttps://conductscience.org/library/genes/960NCBI Gene
CD8A925PubTator's text mininghttps://conductscience.org/library/genes/925NCBI Gene
DLL454,567PubTator's text mininghttps://conductscience.org/library/genes/54567NCBI Gene
FOXN18,456PubTator's text mininghttps://conductscience.org/library/genes/8456NCBI Gene
IL2RA3,559PubTator's text mininghttps://conductscience.org/library/genes/3559NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Trials
  • Comments and corrections
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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