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Paper · 34196366

The Eyes Absent proteins in development and in developmental disorders.

Soni UK and 2 others. Biochem Soc Trans, 2021. Cited by 16 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The Eyes Absent proteins in development and in developmental disorders. Papers, record 34196366. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/34196366

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The Eyes Absent proteins in development and in developmental disorders.
PubMed
Journal
Biochem Soc Trans
PubMed
Year
2021
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Review
PubMed
Citations, by iCite
16
iCite
Relative citation ratio, by iCite
1.01
iCite
Revised in PubMed
2022-01-31
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Soni UKUpendra Kumar
2Roychoudhury KKaushik
3Hegde RSRashmi Shttps://orcid.org/0000-0003-2524-7280

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Congenital AbnormalitiesMajor topic
EyeMajor topic
Gene Expression Regulation, DevelopmentalMajor topic
KidneyMajor topic
Protein Tyrosine PhosphatasesMajor topic
Trans-ActivatorsMajor topic
Animals
Genetic Predisposition to Disease
Humans
Mutation

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
R01 HL152094NHLBI NIH HHSUnited StatesR01HL152094PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References90

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
117,568,404A novel splice site mutation in EYA4 causes DFNA10 hearing loss.Am J Med Genet A2007https://conductscience.org/library/papers/17568404PubMed
223,251,383MAPK target sites of eyes absent are not required for eye development or survival in Drosophila.PLoS One2012https://conductscience.org/library/papers/23251383PubMed
318,678,597Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear.Hum Mol Genet2008https://conductscience.org/library/papers/18678597PubMed
414,628,042Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis.Nature2003https://conductscience.org/library/papers/14628042PubMed
519,234,442Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions.Nature2009https://conductscience.org/library/papers/19234442PubMed
620,418,914The Eyes Absent phosphatase-transactivator proteins promote proliferation, transformation, migration, and invasion of tumor cells.Oncogene2010https://conductscience.org/library/papers/20418914PubMed
733,649,104Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis.Mol Cancer Ther2021https://conductscience.org/library/papers/33649104PubMed
816,797,546Branchio-oto-renal syndrome associated mutations in Eyes Absent 1 result in loss of phosphatase activity.FEBS Lett2006https://conductscience.org/library/papers/16797546PubMed
922,971,774The Eyes Absent proteins in development and disease.Cell Mol Life Sci2013https://conductscience.org/library/papers/22971774PubMed
1033,242,174Expression of Eya1 in mouse taste buds.Cell Tissue Res2021https://conductscience.org/library/papers/33242174PubMed

1 to 10 of 90

See all 90 references

Cited by14

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 16 citations.

PMIDTitleJournalYearIn PapersSource
42,539,001Genetic and Pharmacologic Targeting of Eya3 in Macrophages Drives Anti-Tumor Immunity in Triple-Negative Breast Cancer.bioRxiv2026https://conductscience.org/library/papers/42539001PubMed
42,304,399EYA1 regulates CIITA phosphorylation to promote EYA1-CIITA-Runx2 complex formation and extracellular matrix integrity in osteoarthritis.Biol Direct2026https://conductscience.org/library/papers/42304399PubMed
41,501,857DNA methylation analysis of NOTCH1 variants reveals the first episignature for non-syndromic congenital heart defects.Genome Med2026https://conductscience.org/library/papers/41501857PubMed
41,266,088Potent synthetic lethality between PLK1 and EYA family inhibitors in tumors of the central and peripheral nervous systems.Genes Dev2026https://conductscience.org/library/papers/41266088PubMed
41,257,561Genetic and epigenetic markers in the METTL21C gene associated with umbilical hernia in pigs.BMC Genomics2025https://conductscience.org/library/papers/41257561PubMed
39,819,101Familial Oculoauriculovertebral Spectrum: A Genomic Investigation of Autosomal Dominant Inheritance.Cleft Palate Craniofac J2026https://conductscience.org/library/papers/39819101PubMed
39,627,769SIX transcription factors are necessary for the activation of DUX4 expression in facioscapulohumeral muscular dystrophy.Skelet Muscle2024https://conductscience.org/library/papers/39627769PubMed
39,617,783Phosphorylation determines the glucose metabolism reprogramming and tumor-promoting activity of sine oculis homeobox 1.Signal Transduct Target Ther2024https://conductscience.org/library/papers/39617783PubMed
39,381,636Incoherent collective cell chemotaxis underlies organ dysmorphia in a model of branchio-oto-renal syndrome.MicroPubl Biol2024https://conductscience.org/library/papers/39381636PubMed
39,316,168EYA-1 is required for genomic integrity independent of H2AX signalling in Caenorhabditis elegans.Mol Biol Rep2024https://conductscience.org/library/papers/39316168PubMed

1 to 10 of 14

See all 14 cited by

Genes10

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
DACH11,602PubTator's text mininghttps://conductscience.org/library/genes/1602NCBI Gene
EYA12,138PubTator's text mininghttps://conductscience.org/library/genes/2138NCBI Gene
EYA22,139PubTator's text mininghttps://conductscience.org/library/genes/2139NCBI Gene
LFNG3,955PubTator's text mininghttps://conductscience.org/library/genes/3955NCBI Gene
NKX2-51,482PubTator's text mininghttps://conductscience.org/library/genes/1482NCBI Gene
PAX35,077PubTator's text mininghttps://conductscience.org/library/genes/5077NCBI Gene
PTPN2226,191PubTator's text mininghttps://conductscience.org/library/genes/26191NCBI Gene
SIX16,495PubTator's text mininghttps://conductscience.org/library/genes/6495NCBI Gene
SIX5147,912PubTator's text mininghttps://conductscience.org/library/genes/147912NCBI Gene
SOX26,657PubTator's text mininghttps://conductscience.org/library/genes/6657NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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