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Paper · 36740702

Dual-AAV split prime editor corrects the mutation and phenotype in mice with inherited retinal degeneration.

She K and 12 others. Signal Transduct Target Ther, 2023. Cited by 86 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Dual-AAV split prime editor corrects the mutation and phenotype in mice with inherited retinal degeneration. Papers, record 36740702. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/36740702

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Dual-AAV split prime editor corrects the mutation and phenotype in mice with inherited retinal degeneration.
PubMed
Journal
Signal Transduct Target Ther
PubMed
Year
2023
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
86
iCite
Relative citation ratio, by iCite
7.78
iCite
Revised in PubMed
2023-03-10
PubMed

Authors13

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1She KKaiqin
2Liu YYi
3Zhao QQinyu
4Jin XXiu
5Yang YYiliu
6Su JJing
7Li RRuiting
8Song LLi
9Xiao JJianlu
10Yao SShaohua

1 to 10 of 13Source PubMed

See all 13 authors

Topics7

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Retinal DegenerationMajor topic
Leber Congenital AmaurosisMajor topic
Mice
Animals
Dependovirus
Mutation
Phenotype

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References39

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
127,694,915Integration and exchange of split dCas9 domains for transcriptional controls in mammalian cells.Nat Commun2016https://conductscience.org/library/papers/27694915PubMed
225,830,891In vivo genome editing using Staphylococcus aureus Cas9.Nature2015https://conductscience.org/library/papers/25830891PubMed
333,837,189Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice.Nat Commun2021https://conductscience.org/library/papers/33837189PubMed
434,653,350Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.Cell2021https://conductscience.org/library/papers/34653350PubMed
532,993,386Genome-Editing Strategies for Treating Human Retinal Degenerations.Hum Gene Ther2021https://conductscience.org/library/papers/32993386PubMed
629,856,367Gene therapy and genome surgery in the retina.J Clin Invest2018https://conductscience.org/library/papers/29856367PubMed
735,379,962A split prime editor with untethered reverse transcriptase and circular RNA template.Nat Biotechnol2022https://conductscience.org/library/papers/35379962PubMed
812,915,444Complexin II is essential for normal neurological function in mice.Hum Mol Genet2003https://conductscience.org/library/papers/12915444PubMed
935,294,257In vivo prime editing of a metabolic liver disease in mice.Sci Transl Med2022https://conductscience.org/library/papers/35294257PubMed
1026,082,496Development of an intein-mediated split-Cas9 system for gene therapy.Nucleic Acids Res2015https://conductscience.org/library/papers/26082496PubMed

1 to 10 of 39

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Cited by66

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 86 citations.

PMIDTitleJournalYearIn PapersSource
42,957,916Research progress of gene correction for genetic diseases via in vivo prime editing.Mol Genet Genomics2026https://conductscience.org/library/papers/42957916PubMed
42,920,906Minimal indel-inducing and window-adjustable base editing using inactive Cas12b effectors.Mol Ther Nucleic Acids2026https://conductscience.org/library/papers/42920906PubMed
42,786,151Therapeutic modulation of the vitreoretinal fibrosis microenvironment in female mice using engineered macrophage-derived extracellular vesicles.Nat Commun2026https://conductscience.org/library/papers/42786151PubMed
42,728,339Dense RNA motif modifications enable robust in vivo prime editing and enhance efficiencies of diverse editing systems.Nat Biomed Eng2026https://conductscience.org/library/papers/42728339PubMed
42,621,064A surgically compatible shape memory alloy electroporation electrode for delivering DNA to the living retina.Mater Today Bio2026https://conductscience.org/library/papers/42621064PubMed
42,587,136Mechanistic machine learning for prediction of prime editing outcomes.Nat Biotechnol2026https://conductscience.org/library/papers/42587136PubMed
42,577,403Highly efficient CRISPR editing enabled by magnetic nanoparticle delivery.Front Genome Ed2026https://conductscience.org/library/papers/42577403PubMed
42,444,979Delivery Systems for Therapeutic Genome Editing: Challenges, Innovations, and Future Perspectives.MedComm (2020)2026https://conductscience.org/library/papers/42444979PubMed
42,346,201Research Progress on the Pathogenesis and Diagnostic and Therapeutic Potential of Ciliopathies Regulated by IFT172.Clin Genet2026https://conductscience.org/library/papers/42346201PubMed
42,240,651Adapting prime editing with split prime editors in Escherichia coli and its application to Staphylococcus aureus genome editing.Appl Microbiol Biotechnol2026https://conductscience.org/library/papers/42240651PubMed

1 to 10 of 66

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Genes8

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
DNMT11,786PubTator's text mininghttps://conductscience.org/library/genes/1786NCBI Gene
ERF2,077PubTator's text mininghttps://conductscience.org/library/genes/2077NCBI Gene
GAPDH2,597PubTator's text mininghttps://conductscience.org/library/genes/2597NCBI Gene
PCSK9255,738PubTator's text mininghttps://conductscience.org/library/genes/255738NCBI Gene
RNF26,045PubTator's text mininghttps://conductscience.org/library/genes/6045NCBI Gene
RPE656,121PubTator's text mininghttps://conductscience.org/library/genes/6121NCBI Gene
TJP17,082PubTator's text mininghttps://conductscience.org/library/genes/7082NCBI Gene
VEGFA7,422PubTator's text mininghttps://conductscience.org/library/genes/7422NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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