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Paper · 39136993

IL-13 and IL-17A activate β1 integrin through an NF-kB/Rho kinase/PIP5K1γ pathway to enhance force transmission in airway smooth muscle.

Ngo U and 7 others. Proc Natl Acad Sci U S A, 2024. Cited by 14 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. IL-13 and IL-17A activate β1 integrin through an NF-kB/Rho kinase/PIP5K1γ pathway to enhance force transmission in airway smooth muscle. Papers, record 39136993. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/39136993

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
IL-13 and IL-17A activate β1 integrin through an NF-kB/Rho kinase/PIP5K1γ pathway to enhance force transmission in airway smooth muscle.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
2024
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, N.I.H., Extramural
PubMed
Citations, by iCite
14
iCite
Relative citation ratio, by iCite
2.18, provisional
iCite
Revised in PubMed
2026-08-20
PubMed

Authors8

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Ngo UUyen
2Shi YYinghttps://orcid.org/0000-0002-9263-4320
3Woodruff PPrescott
4Shokat KKevan
5DeGrado WWilliamhttps://orcid.org/0000-0003-4745-263X
6Jo HHyunil
7Sheppard DDeanhttps://orcid.org/0000-0002-6277-2036
8Sundaram ABAparna Bhttps://orcid.org/0000-0002-4076-4756

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Integrin beta1Major topic
Interleukin-17Major topic
Muscle, SmoothMajor topic
NF-kappa BMajor topic
rho-Associated KinasesMajor topic
Interleukin-13Major topic
AsthmaMajor topic
Humans
Signal Transduction
Cell Adhesion
Myocytes, Smooth Muscle
Animals

Source PubMed

Grants5

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
K08 HL124049NHLBI NIH HHSUnited StatesK08HL124049PubMed and NIHNIH RePORTER
R01 HL173342NHLBI NIH HHSUnited StatesR01HL173342PubMed and NIHNIH RePORTER
R61 HL163725NHLBI NIH HHSUnited StatesR61HL163725PubMed and NIHNIH RePORTER
R35 GM122603NIGMS NIH HHSUnited StatesR35GM122603PubMed and NIHNIH RePORTER
P01 HL146373NHLBI NIH HHSUnited StatesP01HL146373PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Update of38,746,410IL-13 and IL-17A Activate β1 Integrin through an NF-kB/Rho kinase/PIP5K1γ pathway to Enhance Force Transmission in Airway Smooth Muscle.https://conductscience.org/library/papers/38746410

Source PubMed

References70

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
114,500,982Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins.Science2003https://conductscience.org/library/papers/14500982PubMed
222,710,802A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion.Cell Res2012https://conductscience.org/library/papers/22710802PubMed
312,422,219Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin.Nature2002https://conductscience.org/library/papers/12422219PubMed
412,297,042Integrins: bidirectional, allosteric signaling machines.Cell2002https://conductscience.org/library/papers/12297042PubMed
521,689,521Spatiotemporal constraints on the force-dependent growth of focal adhesions.Biophys J2011https://conductscience.org/library/papers/21689521PubMed
618,321,931Extracellular matrix components and regulators in the airway smooth muscle in asthma.Eur Respir J2008https://conductscience.org/library/papers/18321931PubMed
78,584,934Role of Rho in chemoattractant-activated leukocyte adhesion through integrins.Science1996https://conductscience.org/library/papers/8584934PubMed
833,956,668Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models.J Clin Invest2021https://conductscience.org/library/papers/33956668PubMed
927,207,789The Rap1-RIAM-talin axis of integrin activation and blood cell function.Blood2016https://conductscience.org/library/papers/27207789PubMed
10574,143Exposure of platelet fibrinogen receptors by ADP and epinephrine.J Clin Invest1979https://conductscience.org/library/papers/574143PubMed

1 to 10 of 70

See all 70 references

Cited by12

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 14 citations.

PMIDTitleJournalYearIn PapersSource
42,572,038Mechanisms and therapeutic strategies of asthma: from bench to bedside.Signal Transduct Target Ther2026https://conductscience.org/library/papers/42572038PubMed
41,970,196Asthma endotypes and theratypes.Chin Med J Pulm Crit Care Med2026https://conductscience.org/library/papers/41970196PubMed
41,834,839Histopathological alterations in airways associated with physiological changes in airway allergy phenotypes.Front Allergy2026https://conductscience.org/library/papers/41834839PubMed
41,676,247Fasudil improves neutrophilic asthma by influencing M1 macrophage polarization and the expression of the NF-κB/TLR-2/RPS3 pathway.Am J Transl Res2026https://conductscience.org/library/papers/41676247PubMed
41,427,225Structure-Based Discovery of Potent and Selective Small-Molecule α5β1 Integrin Inhibitors for Asthma Therapy.ACS Omega2025https://conductscience.org/library/papers/41427225PubMed
41,154,695High PEEP Activates ITGB1, Inducing Diaphragm Fibrosis During Prolonged Mechanical Ventilation.Biomolecules2025https://conductscience.org/library/papers/41154695PubMed
40,999,889Tackling Allergic Airway Inflammation with Organic Sheet-Like Nanoplatforms by Targeted Elimination of Epithelial Small Extracellular Vesicles.Adv Sci (Weinh)2025https://conductscience.org/library/papers/40999889PubMed
40,898,182Implicates of PIP5K1α in asthma-related biological processes: insights into mechanisms and therapeutic potential.J Transl Med2025https://conductscience.org/library/papers/40898182PubMed
40,257,546Targeting IL-13 and IL-4 in Asthma: Therapeutic Implications on Airway Remodeling in Severe Asthma.Clin Rev Allergy Immunol2025https://conductscience.org/library/papers/40257546PubMed
40,183,091Inflammation and platelet hyperresponsiveness in coronary artery disease and the influence of Talin-1/αIIbβ3-mediated bidirectional signaling pathway.Front Pharmacol2025https://conductscience.org/library/papers/40183091PubMed

1 to 10 of 12

See all 12 cited by

Genes7

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
IL133,596PubTator's text mininghttps://conductscience.org/library/genes/3596NCBI Gene
IL17A3,605PubTator's text mininghttps://conductscience.org/library/genes/3605NCBI Gene
ITGB13,688PubTator's text mininghttps://conductscience.org/library/genes/3688NCBI Gene
MS4A1931PubTator's text mininghttps://conductscience.org/library/genes/931NCBI Gene
NFKB14,790PubTator's text mininghttps://conductscience.org/library/genes/4790NCBI Gene
PIP5K1C23,396PubTator's text mininghttps://conductscience.org/library/genes/23396NCBI Gene
RHOA387PubTator's text mininghttps://conductscience.org/library/genes/387NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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