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Paper · 39448564

Suppressive cancer nonstop extension mutations increase C-terminal hydrophobicity and disrupt evolutionarily conserved amino acid patterns.

Ghosh A and 8 others. Nat Commun, 2024. Cited by 6 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Suppressive cancer nonstop extension mutations increase C-terminal hydrophobicity and disrupt evolutionarily conserved amino acid patterns. Papers, record 39448564. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/39448564

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Suppressive cancer nonstop extension mutations increase C-terminal hydrophobicity and disrupt evolutionarily conserved amino acid patterns.
PubMed
Journal
Nat Commun
PubMed
Year
2024
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
6
iCite
Relative citation ratio, by iCite
0.62, provisional
iCite
Revised in PubMed
2025-05-30
PubMed

Authors9

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Ghosh AAvantika
2Riester MMarisa
3Pal JJagriti
4Lainde KAKadri-Ann
5Tangermann CCarlahttps://orcid.org/0000-0002-4715-4985
6Wanninger AAngela
7Dueren UKUrsula K
8Dhamija SSonam
9Diederichs SSvenhttps://orcid.org/0000-0001-7901-4752

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Hydrophobic and Hydrophilic InteractionsMajor topic
NeoplasmsMajor topic
MutationMajor topic
Humans
Amino Acids
Smad4 Protein
MutL Protein Homolog 1
PTEN Phosphohydrolase
Evolution, Molecular
Codon, Terminator
Adenomatous Polyposis Coli Protein
Animals
Proteome
Genes, Tumor Suppressor
Conserved Sequence

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
Di 1421/9-2Deutsche Forschungsgemeinschaft (German Research Foundation)PubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References73

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
121,833,082A continuum model for tumour suppression.Nature2011https://conductscience.org/library/papers/21833082PubMed
211,175,795Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse.Nat Genet2001https://conductscience.org/library/papers/11175795PubMed
311,375,494Impairment of the ubiquitin-proteasome system by protein aggregation.Science2001https://conductscience.org/library/papers/11375494PubMed
429,779,948The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons.Cell2018https://conductscience.org/library/papers/29779948PubMed
526,488,274Bacterial Proteasomes.Annu Rev Microbiol2015https://conductscience.org/library/papers/26488274PubMed
629,124,833A nonstop variant in REEP1 causes peripheral neuropathy by unmasking a 3'UTR-encoded, aggregation-inducing motif.Hum Mutat2018https://conductscience.org/library/papers/29124833PubMed
79,090,379Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers.Nat Genet1997https://conductscience.org/library/papers/9090379PubMed
821,150,893A novel, non-stop mutation in FOXE3 causes an autosomal dominant form of variable anterior segment dysgenesis including Peters anomaly.Eur J Hum Genet2011https://conductscience.org/library/papers/21150893PubMed
925,586,243Somatic Mutations and Genetic Heterogeneity at the CDKN1B Locus in Small Intestinal Neuroendocrine Tumors.Ann Surg Oncol2015https://conductscience.org/library/papers/25586243PubMed
1030,371,878COSMIC: the Catalogue Of Somatic Mutations In Cancer.Nucleic Acids Res2019https://conductscience.org/library/papers/30371878PubMed

1 to 10 of 73

See all 73 references

Cited by6

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 6 citations.

PMIDTitleJournalYearIn PapersSource
42,327,150Saturation Genome Editing reveals the functional impact of RAD51D and XRCC2 variants.bioRxiv2026https://conductscience.org/library/papers/42327150PubMed
42,192,978Single-Nucleotide Polymorphism (SNP) c.73G>A in the UBC9 (E2) SUMO Gene and Breast Cancer Risk in Polish Women.Cancers (Basel)2026https://conductscience.org/library/papers/42192978PubMed
41,634,034Protein C-terminal variations impact proteostasis.Nat Commun2026https://conductscience.org/library/papers/41634034PubMed
41,556,340A predictive framework for stop-loss variants with C-terminal extensions.Nucleic Acids Res2026https://conductscience.org/library/papers/41556340PubMed
41,278,537To be or not to be a protein coding mutation, that's the question!NAR Genom Bioinform2025https://conductscience.org/library/papers/41278537PubMed
39,937,911Nonstop mutations cause loss of renal tumor suppressor proteins VHL and BAP1 and affect multiple stages of protein translation.Sci Adv2025https://conductscience.org/library/papers/39937911PubMed

Genes7

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
APC324PubTator's text mininghttps://conductscience.org/library/genes/324NCBI Gene
B2M567PubTator's text mininghttps://conductscience.org/library/genes/567NCBI Gene
CASP8841PubTator's text mininghttps://conductscience.org/library/genes/841NCBI Gene
CDKN1B1,027PubTator's text mininghttps://conductscience.org/library/genes/1027NCBI Gene
MLH14,292PubTator's text mininghttps://conductscience.org/library/genes/4292NCBI Gene
PTEN5,728PubTator's text mininghttps://conductscience.org/library/genes/5728NCBI Gene
SMAD44,089PubTator's text mininghttps://conductscience.org/library/genes/4089NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data2

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bankAccessionSource
SRAPRJNA1099128SRA
BioProjectPRJNA1099128BioProject

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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