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Paper · 41707651

Syndecan-1-targeted therapeutic antibody impairs macropinocytosis and elicits antitumor immunity in pancreatic cancer.

Yang Z and 22 others. Cell Rep Med, 2026. Cited by 1 paper, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Syndecan-1-targeted therapeutic antibody impairs macropinocytosis and elicits antitumor immunity in pancreatic cancer. Papers, record 41707651. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/41707651

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Syndecan-1-targeted therapeutic antibody impairs macropinocytosis and elicits antitumor immunity in pancreatic cancer.
PubMed
Journal
Cell Rep Med
PubMed
Year
2026
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
1
iCite
Revised in PubMed
2026-08-13
PubMed

Authors23

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Yang ZZecheng
2Theardy MSMadelaine S
3Chen SShuaitong
4Wei YYongkun
5Takeda MMitsunobu
6Zeng YYue
7Wang XXiaofei
8Yao JJun
9Li JJennifer
10Thirasastr PPrapassorn

1 to 10 of 23Source PubMed

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Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Syndecan-1Major topic
PinocytosisMajor topic
Pancreatic NeoplasmsMajor topic
Antibodies, MonoclonalMajor topic
Carcinoma, Pancreatic DuctalMajor topic
Humans
Animals
Cell Line, Tumor
Mice
Cell Proliferation
Antibody-Dependent Cell Cytotoxicity
Female
Xenograft Model Antitumor Assays

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
P01 CA117969NCI NIH HHSUnited StatesP01CA117969PubMedNIH RePORTER
R21 CA288804NCI NIH HHSUnited StatesR21CA288804PubMedNIH RePORTER
R37 CA272744NCI NIH HHSUnited StatesR37CA272744PubMedNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References47

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
132,624,826Producing defucosylated antibodies with enhanced in vitro antibody-dependent cellular cytotoxicity via FUT8 knockout CHO-S cells.Eng Life Sci2017https://conductscience.org/library/papers/32624826PubMed
232,314,115SDC1 promotes cisplatin resistance in hepatic carcinoma cells via PI3K-AKT pathway.Hum Cell2020https://conductscience.org/library/papers/32314115PubMed
332,005,945Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer.Nat Rev Gastroenterol Hepatol2020https://conductscience.org/library/papers/32005945PubMed
430,990,168Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability.Elife2019https://conductscience.org/library/papers/30990168PubMed
522,389,160Dosimetry results suggest feasibility of radioimmunotherapy using anti-CD138 (B-B4) antibody in multiple myeloma patients.Tumour Biol2012https://conductscience.org/library/papers/22389160PubMed
633,022,971The Immune Microenvironment in Pancreatic Cancer.Int J Mol Sci2020https://conductscience.org/library/papers/33022971PubMed
738,935,528PLL-g-PEG Polymer Inhibits Antibody-Drug Conjugate Uptake into Human Corneal Epithelial Cells In Vitro.J Ocul Pharmacol Ther2024https://conductscience.org/library/papers/38935528PubMed
828,187,290Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy.Cell2017https://conductscience.org/library/papers/28187290PubMed
936,509,911Rational combinations of targeted cancer therapies: background, advances and challenges.Nat Rev Drug Discov2023https://conductscience.org/library/papers/36509911PubMed
1027,578,889Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions.Protein Eng Des Sel2016https://conductscience.org/library/papers/27578889PubMed

1 to 10 of 47

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Cited by1

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1 citation.

PMIDTitleJournalYearIn Papers
42,522,137Molecular interplay of insulin resistance and cancer: advances in monoclonal antibody therapeutics.Cancer Biol Ther2026https://conductscience.org/library/papers/42522137

Source PubMed

Genes21

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ALB213PubTator's text mininghttps://conductscience.org/library/genes/213NCBI Gene
CD4920PubTator's text mininghttps://conductscience.org/library/genes/920NCBI Gene
CD44960PubTator's text mininghttps://conductscience.org/library/genes/960NCBI Gene
CD69969PubTator's text mininghttps://conductscience.org/library/genes/969NCBI Gene
CD8A925PubTator's text mininghttps://conductscience.org/library/genes/925NCBI Gene
EGF1,950PubTator's text mininghttps://conductscience.org/library/genes/1950NCBI Gene
ERBB22,064PubTator's text mininghttps://conductscience.org/library/genes/2064NCBI Gene
FCGR3A2,214PubTator's text mininghttps://conductscience.org/library/genes/2214NCBI Gene
FUT82,530PubTator's text mininghttps://conductscience.org/library/genes/2530NCBI Gene
IFNG3,458PubTator's text mininghttps://conductscience.org/library/genes/3458NCBI Gene

1 to 10 of 21

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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