Paper · 6163083

The structure of eight distinct cloned human leukocyte interferon cDNAs.

Goeddel DV and 9 others. Nature, 1981. Cited by 504 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The structure of eight distinct cloned human leukocyte interferon cDNAs. Papers, record 6163083. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6163083

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: The structure of eight distinct cloned human leukocyte interferon cDNAs.; PubMed
Journal: Nature; PubMed
Year: 1981; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/6163083/; PubMed
DOI: https://doi.org/10.1038/290020a0; PubMed
The journal: https://conductscience.org/library/journal-index/0410462; PubMed
Citations, by iCite: 504; iCite
Relative citation ratio, by iCite: 13; iCite
Revised in PubMed: 2019-06-17; PubMed

Authors10

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Goeddel DV	D V
2	Leung DW	D W
3	Dull TJ	T J
4	Gross M	M
5	Lawn RM	R M
6	McCandliss R	R
7	Seeburg PH	P H
8	Ullrich A	A
9	Yelverton E	E
10	Gray PW	P W

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Interferons	Major topic
Amino Acid Sequence
Base Sequence
Cloning, Molecular
Codon
DNA Restriction Enzymes
Genes, Synthetic
Humans
Leukocytes
Nucleic Acid Hybridization
Protein Precursors
Transcription, Genetic

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by99

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 504 citations.

PMID	Title	Journal	Year	In Papers	Source
37,648,466	Cloning of human Type I interferon cDNAs.	Proc Jpn Acad Ser B Phys Biol Sci	2024	https://conductscience.org/library/papers/37648466	PubMed
32,014,632	Camelid type I interferons: Identification and functional characterization of interferon alpha from the dromedary camel (Camelus dromedarius).	Mol Immunol	2020	https://conductscience.org/library/papers/32014632	PubMed
21,398,401	Pseudogenes: pseudo-functional or key regulators in health and disease?	RNA	2011	https://conductscience.org/library/papers/21398401	PubMed
19,754,956	Assessing the genomic evidence for conserved transcribed pseudogenes under selection.	BMC Genomics	2009	https://conductscience.org/library/papers/19754956	PubMed
18,049,472	Interferons at age 50: past, current and future impact on biomedicine.	Nat Rev Drug Discov	2007	https://conductscience.org/library/papers/18049472	PubMed
17,494,769	Directed evolution of gene-shuffled IFN-alpha molecules with activity profiles tailored for treatment of chronic viral diseases.	Proc Natl Acad Sci U S A	2007	https://conductscience.org/library/papers/17494769	PubMed
17,346,794	Gene cloning, sequencing, expression and biological activity of giant panda (Ailuropoda melanoleuca) interferon-alpha.	Mol Immunol	2007	https://conductscience.org/library/papers/17346794	PubMed
10,713,678	Regulation of mda-7 gene expression during human melanoma differentiation.	Oncogene	2000	https://conductscience.org/library/papers/10713678	PubMed
9,836,373	Role of pro-inflammatory cytokines in rheumatoid arthritis.	Springer Semin Immunopathol	1998	https://conductscience.org/library/papers/9836373	PubMed
9,425,112	Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.	Biochem J	1998	https://conductscience.org/library/papers/9425112	PubMed

1 to 10 of 99

See all 99 cited by

Genes9

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
IFNA1	3,439	Swiss-Prot's references	https://conductscience.org/library/genes/3439	NCBI Gene
IFNA10	3,446	Swiss-Prot's references	https://conductscience.org/library/genes/3446	NCBI Gene
IFNA14	3,448	Swiss-Prot's references	https://conductscience.org/library/genes/3448	NCBI Gene
IFNA2	3,440	Swiss-Prot's references	https://conductscience.org/library/genes/3440	NCBI Gene
IFNA21	3,452	Swiss-Prot's references	https://conductscience.org/library/genes/3452	NCBI Gene
IFNA5	3,442	Swiss-Prot's references	https://conductscience.org/library/genes/3442	NCBI Gene
IFNA8	3,445	Swiss-Prot's references	https://conductscience.org/library/genes/3445	NCBI Gene
IFNA13	3,447	PubTator's text mining	https://conductscience.org/library/genes/3447	NCBI Gene
IFNA22P	3,453	PubTator's text mining	https://conductscience.org/library/genes/3453	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data9

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bank	Accession	Source
GENBANK	J00207	GENBANK
GENBANK	J00208	GENBANK
GENBANK	J00209	GENBANK
GENBANK	J00210	GENBANK
GENBANK	J00211	GENBANK
GENBANK	J00212	GENBANK
GENBANK	J00213	GENBANK
GENBANK	J00214	GENBANK
GENBANK	V00544	GENBANK

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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