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Paper68998

A suppressor T cell in the human mixed lymphocyte reaction.

McMichael AJ and 1 other. J Exp Med, 1977. Cited by 100 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A suppressor T cell in the human mixed lymphocyte reaction. Papers, record 68998. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/68998

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
A suppressor T cell in the human mixed lymphocyte reaction.
PubMed
Journal
J Exp Med
PubMed
Year
1977
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
100
iCite
Relative citation ratio, by iCite
2.85
iCite
Revised in PubMed
2021-12-03
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1McMichael AJA J
2Sasazuki TT

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
HLA AntigensMajor topic
Histocompatibility AntigensMajor topic
Immunosuppression TherapyMajor topic
T-LymphocytesMajor topic
Cells, Cultured
Epitopes
Female
Homozygote
Humans
Immunologic Techniques
In Vitro Techniques
Lymphocyte Culture Test, Mixed
Male
Time Factors

Source PubMed

References16

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,085,338A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes.J Exp Med1976https://conductscience.org/library/papers/1085338PubMed
21,085,339
Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex.
J Exp Med1976https://conductscience.org/library/papers/1085339PubMed
31,092,798Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.J Exp Med1975https://conductscience.org/library/papers/1092798PubMed
41,101,468Properties of primed suppressor T cells and their products.Transplant Rev1975https://conductscience.org/library/papers/1101468PubMed
51,103,386Regulation of immunoglobulin and antibody production by allotype suppressor T cells in mice.Transplant Rev1975https://conductscience.org/library/papers/1103386PubMed
6131,987Use of high dose X-irradiation to block back stimulation in the MLC reaction.Tissue Antigens1976https://conductscience.org/library/papers/131987PubMed
74,105,624Cooperating and controlling functions of thymus-derived lymphocytes in relation to autoimmunity.Lancet1971https://conductscience.org/library/papers/4105624PubMed
84,137,682Genetic control of immune responses in vitro. V. Stimulation of suppressor T cells in nonresponder mice by the terpolymer L-glutamic acid 60-L-alanine 30-L-tyrosine 10 (GAT).J Exp Med1974https://conductscience.org/library/papers/4137682PubMed
94,137,918Role of suppressor T cells in pathogenesis of common variable hypogammaglobulinaemia.Lancet1974https://conductscience.org/library/papers/4137918PubMed
104,151,107Regulation of the antibody response to type 3 pneumococcal polysaccharide. IV. Role of suppressor T cells in the development of low-dose paralysis.J Immunol1974https://conductscience.org/library/papers/4151107PubMed
114,279,271Regulatory mechanisms in cell-mediated immune responses. I. Regulation of mixed lymphocyte reactions by alloantigen-activated thymus-derived lymphocytes.J Exp Med1974https://conductscience.org/library/papers/4279271PubMed
124,583,095Depression of the T cell phenomenon of contact sensitivity by T cells from unresponsive mice.Nature1973https://conductscience.org/library/papers/4583095PubMed
134,943,147Infectious immunological tolerance.Immunology1971https://conductscience.org/library/papers/4943147PubMed
1453,264Regulatory mechanisms in cell-mediated immune responses. II. A genetically restricted suppressor of mixed lymphocyte reactions released by alloantigen-activated spleen cells.J Exp Med1975https://conductscience.org/library/papers/53264PubMed
155,477,932Lymphocyte transformation in vitro. 3. Mechanism of stimulation in the mixed lymphocyte culture.Clin Exp Immunol1970https://conductscience.org/library/papers/5477932PubMed
165,918,139Thymus-marrow cell combinations. Synergism in antibody production.Proc Soc Exp Biol Med1966https://conductscience.org/library/papers/5918139PubMed

Cited by18

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 100 citations.

PMIDTitleJournalYearIn PapersSource
7,174,000Preliminary studies of the feline histocompatibility system.Immunogenetics1982https://conductscience.org/library/papers/7174000PubMed
6,978,205In vitro synthesis of IgE by human peripheral blood leucocytes. II modulation of IgE B cell activity by isotype-specific regulatory T cells.Clin Exp Immunol1981https://conductscience.org/library/papers/6978205PubMed
6,818,146Effect of pregnancy on resistance to Listeria monocytogenes and Toxoplasma gondii infections in mice.Infect Immun1982https://conductscience.org/library/papers/6818146PubMed
6,811,173The effect of bacterial peptidoglycans on the immune response of hamsters to influenza virus vaccines.Clin Exp Immunol1982https://conductscience.org/library/papers/6811173PubMed
6,459,996
Regulation of the human allogenic proliferative response in vitro. II. Production of soluble suppressor factors by suppressor T cells and evidence in favor of "acceptor" cells for suppression among unprimed lymphocytes.
Immunogenetics1981https://conductscience.org/library/papers/6459996PubMed
6,459,995Regulation of the human allogeneic proliferative response in vitro.Immunogenetics1981https://conductscience.org/library/papers/6459995PubMed
6,455,226Maternal regulator cells during murine pregnancy.Clin Exp Immunol1981https://conductscience.org/library/papers/6455226PubMed
6,455,224Amplification and suppression of human T cell proliferative responses by alloactivated T cells.Clin Exp Immunol1981https://conductscience.org/library/papers/6455224PubMed
6,230,305Reactivity pattern of 15 HLA-Dw1 homozygous typing cells in primary mixed lymphocyte culture.Hum Genet1984https://conductscience.org/library/papers/6230305PubMed
6,200,565
Antigen-specific suppression of human antibody responses by allogeneic T cells. I. Frequency and antigen specificity of allogeneic suppressor T cells and their role in major histocompatibility complex-controlled genetic restriction.
J Exp Med1984https://conductscience.org/library/papers/6200565PubMed
6,157,639Human lymphocyte markers defined by antibodies derived from somatic cell hybrids. III. A marker defining a subpopulation of lymphocytes which cuts across the normal T-B-null classification.Immunology1980https://conductscience.org/library/papers/6157639PubMed
2,989,180Effect of estrogen (17 beta-estradiol) on the susceptibility of mice to disseminated gonococcal infection.Infect Immun1985https://conductscience.org/library/papers/2989180PubMed
311,007Direct evidence for loss of human suppressor cells during active autoimmune disease.Proc Natl Acad Sci U S A1978https://conductscience.org/library/papers/311007PubMed
159,935Immune responses during pregnancy. Evidence of suppressor cells for splenic antibody response.J Exp Med1979https://conductscience.org/library/papers/159935PubMed
158,761Help and suppression by lymphoid cells as a function of cellular concentration.Proc Natl Acad Sci U S A1979https://conductscience.org/library/papers/158761PubMed
155,076Changes in lymphocyte activity after thermal injury. The role of suppressor cells.J Clin Invest1979https://conductscience.org/library/papers/155076PubMed
148,486Suppression of the mixed lymphocyte reaction in man by a soluble T-cell factor. Specificity of the factor for both responder and stimulator.J Exp Med1978https://conductscience.org/library/papers/148486PubMed
147,885A suppressor T cell of the mixed lymphocyte reaction specific for the HLA-D region in man.J Clin Invest1978https://conductscience.org/library/papers/147885PubMed

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
HLA-A3,105PubTator's text mininghttps://conductscience.org/library/genes/3105

Source NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

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  • Comments and corrections
  • Drugs
  • Data

Sources 11

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  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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