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Paper147885

A suppressor T cell of the mixed lymphocyte reaction specific for the HLA-D region in man.

Engleman EG and 1 other. J Clin Invest, 1978. Cited by 54 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A suppressor T cell of the mixed lymphocyte reaction specific for the HLA-D region in man. Papers, record 147885. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/147885

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
A suppressor T cell of the mixed lymphocyte reaction specific for the HLA-D region in man.
PubMed
Journal
J Clin Invest
PubMed
Year
1978
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
54
iCite
Relative citation ratio, by iCite
1.44
iCite
Revised in PubMed
2021-12-03
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Engleman EGE G
2McDevitt HOH O

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
HLA AntigensMajor topic
Immunosuppression TherapyMajor topic
T-LymphocytesMajor topic
Adult
Antibody-Dependent Cell Cytotoxicity
B-Lymphocytes
Blood Cell Count
Female
Humans
Lymphocyte Culture Test, Mixed
Male
Mitogens
Monocytes
Time Factors
Toxoids

Source PubMed

References21

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,082,394Increased sensitivity of the rosette-forming reaction of human T lymphocytes with sheep erythrocytes afforded by papain treatment of the sheep cells.Clin Exp Immunol1975https://conductscience.org/library/papers/1082394PubMed
21,082,888Suppressor thymus-derived lymphocytes in fungal infection.J Clin Invest1976https://conductscience.org/library/papers/1082888PubMed
3125,290Hodgkin's disease. An immunodepleting and immunosuppressive disorder.J Clin Invest1975https://conductscience.org/library/papers/125290PubMed
4126,252Alteration of T cell function in healthy persons with a history of thymic x-irradiation.J Allergy Clin Immunol1975https://conductscience.org/library/papers/126252PubMed
5129,500Regulatory mechanisms in cell-mediated immune responses. III. I-region control of suppressor cell interaction with responder cells in mixed lymphocyte reactions.J Exp Med1976https://conductscience.org/library/papers/129500PubMed
6142,998The association between the HLA system and disease.Prog Med Genet1977https://conductscience.org/library/papers/142998PubMed
84,109,878Histocompatibility-linked immune response genes.Science1972https://conductscience.org/library/papers/4109878PubMed
94,130,690Identification and quantitation of thymus-derived lymphocytes in human peripheral blood.J Immunol1974https://conductscience.org/library/papers/4130690PubMed
104,137,918Role of suppressor T cells in pathogenesis of common variable hypogammaglobulinaemia.Lancet1974https://conductscience.org/library/papers/4137918PubMed
114,272,110Importance of different regions of H-2 for MLC stimulation.Tissue Antigens1973https://conductscience.org/library/papers/4272110PubMed
124,275,076Immunity to tissue sensitisation, HL-A and non-HL-A, as detected by the ABCIL system.Transplantation1974https://conductscience.org/library/papers/4275076PubMed
134,399,834Three closely linked genetic systems relevant to transplantation.Proc Natl Acad Sci U S A1971https://conductscience.org/library/papers/4399834PubMed
144,637,806Ragweed hay fever: genetic control and linkage to HL-A haplotypes.Science1972https://conductscience.org/library/papers/4637806PubMed
1547,219The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.Adv Immunol1975https://conductscience.org/library/papers/47219PubMed
164,833,283Genetic mapping of Ir locus in man: linkage to second locus of HL-A.Science1974https://conductscience.org/library/papers/4833283PubMed
175,021,837Effect of radiation upon the "embryonic" thymus.Radiat Res1972https://conductscience.org/library/papers/5021837PubMed
1853,264Regulatory mechanisms in cell-mediated immune responses. II. A genetically restricted suppressor of mixed lymphocyte reactions released by alloantigen-activated spleen cells.J Exp Med1975https://conductscience.org/library/papers/53264PubMed
195,330,737Regeneration of thymus grafts. II. Effects on immunological capacity.Clin Exp Immunol1966https://conductscience.org/library/papers/5330737PubMed
2068,998A suppressor T cell in the human mixed lymphocyte reaction.J Exp Med1977https://conductscience.org/library/papers/68998PubMed
21854,964The immune response to diphtheria toxoid in humans.Transplant Proc1977https://conductscience.org/library/papers/854964PubMed

See all 21 references

Cited by13

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 54 citations.

PMIDTitleJournalYearIn PapersSource
28,737,722Induction of a Regulatory Phenotype in CD3+ CD4+ HLA-DR+ T Cells after Allogeneic Mixed Lymphocyte Culture; Indications of Both Contact-Dependent and -Independent Activation.Int J Mol Sci2017https://conductscience.org/library/papers/28737722PubMed
7,009,976[The significance of Fc-IgG and Fc-IgM receptors on human T-lymphocytes (author's transl)].Klin Wochenschr1981https://conductscience.org/library/papers/7009976PubMed
6,979,605Anti-Ia antibody in the sera of normal subjects after in vivo antigenic stimulation.J Exp Med1982https://conductscience.org/library/papers/6979605PubMed
6,811,606Autoimmunity and HLA.J Clin Immunol1982https://conductscience.org/library/papers/6811606PubMed
6,461,456The use of concanavalin A to study the immunoregulation of human T cells.Clin Exp Immunol1981https://conductscience.org/library/papers/6461456PubMed
6,459,996
Regulation of the human allogenic proliferative response in vitro. II. Production of soluble suppressor factors by suppressor T cells and evidence in favor of "acceptor" cells for suppression among unprimed lymphocytes.
Immunogenetics1981https://conductscience.org/library/papers/6459996PubMed
6,459,995Regulation of the human allogeneic proliferative response in vitro.Immunogenetics1981https://conductscience.org/library/papers/6459995PubMed
6,447,166Heterogeneity of b lymphocyte differentiation in severe combined immunodeficiency disease.J Clin Invest1980https://conductscience.org/library/papers/6447166PubMed
6,447,164Autologous mixed lymphocyte reaction in patients with Hodgkin's disease. Evidence for a T cell defect.J Clin Invest1980https://conductscience.org/library/papers/6447164PubMed
6,445,560Functional characteristics of human T-cell subpopulations distinguished by a monoclonal antibody.Proc Natl Acad Sci U S A1980https://conductscience.org/library/papers/6445560PubMed
2,932,467Allogeneic suppressive effects of pregnancy sera on monocytes of responding cells in human mixed lymphocyte reactions.J Clin Invest1985https://conductscience.org/library/papers/2932467PubMed
312,810Studies of immune functions of patients with systemic lupus erythematosus. Complement-dependent immunoglobulin M anti-thymus-derived cell antibodies preferentially inactivate suppressor cells.J Clin Invest1979https://conductscience.org/library/papers/312810PubMed
148,486Suppression of the mixed lymphocyte reaction in man by a soluble T-cell factor. Specificity of the factor for both responder and stimulator.J Exp Med1978https://conductscience.org/library/papers/148486PubMed

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
HLA-A3,105PubTator's text mininghttps://conductscience.org/library/genes/3105NCBI Gene
HLA-B3,106PubTator's text mininghttps://conductscience.org/library/genes/3106NCBI Gene
HLA-C3,107PubTator's text mininghttps://conductscience.org/library/genes/3107NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Drugs
  • Data

Sources 11

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  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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