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Paper148486

Suppression of the mixed lymphocyte reaction in man by a soluble T-cell factor. Specificity of the factor for both responder and stimulator.

Engleman EG and 2 others. J Exp Med, 1978. Cited by 57 papers, by iCite.

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ConductScience Library. Suppression of the mixed lymphocyte reaction in man by a soluble T-cell factor. Specificity of the factor for both responder and stimulator. Papers, record 148486. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/148486

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Suppression of the mixed lymphocyte reaction in man by a soluble T-cell factor. Specificity of the factor for both responder and stimulator.
PubMed
Journal
J Exp Med
PubMed
Year
1978
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
57
iCite
Relative citation ratio, by iCite
1.47
iCite
Revised in PubMed
2021-12-03
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Engleman EGE G
2McMichael AJA J
3McDevitt HOH O

Source PubMed

Topics8

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
HLA AntigensMajor topic
Immunosuppression TherapyMajor topic
T-LymphocytesMajor topic
Antibody Specificity
Humans
Immunity, Cellular
Lymphocyte Culture Test, Mixed
Solubility

Source PubMed

References16

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,085,339
Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex.
J Exp Med1976https://conductscience.org/library/papers/1085339PubMed
21,086,882Regulatory mechanisms in cell-mediated immune responses. IV. Expression of a receptor for mixed lymphocyte reaction suppressor factor on activated T lymphocytes.J Exp Med1976https://conductscience.org/library/papers/1086882PubMed
31,100,764Antigen-specific T-cell factor in cell cooperation. Mapping within the I region of the H-2 complex and ability to cooperate across allogeneic barriers.J Exp Med1975https://conductscience.org/library/papers/1100764PubMed
4147,885A suppressor T cell of the mixed lymphocyte reaction specific for the HLA-D region in man.J Clin Invest1978https://conductscience.org/library/papers/147885PubMed
5320,663Functional specificity of thymus- dependent lymphocytes.Science1977https://conductscience.org/library/papers/320663PubMed
64,503,682Replacement of T-cell function by a T-cell product.Nat New Biol1972https://conductscience.org/library/papers/4503682PubMed
74,545,893Activation of T and B lymphocytes in vitro. II. Biological and biochemical properties of an allogeneic effect factor (AEF) active in triggering specific B lymphocytes.J Exp Med1974https://conductscience.org/library/papers/4545893PubMed
853,264Regulatory mechanisms in cell-mediated immune responses. II. A genetically restricted suppressor of mixed lymphocyte reactions released by alloantigen-activated spleen cells.J Exp Med1975https://conductscience.org/library/papers/53264PubMed
955,436Immunosuppressive factor(s) extracted from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT).J Immunol1976https://conductscience.org/library/papers/55436PubMed
1067,171
Immunosuppressive factor(s) extracted from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) III. Immunochemical properties of the GAT-specific suppressive factor.
J Exp Med1977https://conductscience.org/library/papers/67171PubMed
1168,079Immunosuppressive factor(s) specific for L-glutamic acid50-L-tyrosine50 (GT). I. Production, characterization, and lack of H-2 restriction for activity in recipient strain.J Immunol1977https://conductscience.org/library/papers/68079PubMed
1268,991Immunosuppressive factor(s) specific for L-glutamic acid50-L-tyrosine50 (GT) II. Presence of I-J determinants on the GT-suppressive factor.J Exp Med1977https://conductscience.org/library/papers/68991PubMed
1368,992The I-J subregion codes for determinats on suppressor factor(s) which limit the contact sensitivity response to picryl chloride.J Exp Med1977https://conductscience.org/library/papers/68992PubMed
1468,998A suppressor T cell in the human mixed lymphocyte reaction.J Exp Med1977https://conductscience.org/library/papers/68998PubMed
1575,232A suppressor T cell of the mixed lymphocyte reaction in man specific for the stimulating alloantigen. Evidence that identity at HLA-D between suppressor and responder is required for suppression.J Exp Med1978https://conductscience.org/library/papers/75232PubMed
16782,637Suppressor T cells in cell-mediated immunity.Br Med Bull1976https://conductscience.org/library/papers/782637PubMed

Cited by8

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 57 citations.

PMIDTitleJournalYearIn PapersSource
25,191,324Regulatory T-cells in pregnancy: historical perspective, state of the art, and burning questions.Front Immunol2014https://conductscience.org/library/papers/25191324PubMed
17,626,305The Th1/Th2 paradigm: still important in pregnancy?Semin Immunopathol2007https://conductscience.org/library/papers/17626305PubMed
6,459,991
Genetic control of allogeneic interactions in the guinea-pig. IV. The specific elimination of MLC suppressor cells by the in vivo administration of antisera against a GPLA-B region-controlled determinant.
Immunology1982https://conductscience.org/library/papers/6459991PubMed
6,454,647Regulation of human cytotoxic lymphocyte responses. II. Suppression by a soluble factor produced by primed lymphocytes.Immunology1981https://conductscience.org/library/papers/6454647PubMed
6,230,305Reactivity pattern of 15 HLA-Dw1 homozygous typing cells in primary mixed lymphocyte culture.Hum Genet1984https://conductscience.org/library/papers/6230305PubMed
2,932,467Allogeneic suppressive effects of pregnancy sera on monocytes of responding cells in human mixed lymphocyte reactions.J Clin Invest1985https://conductscience.org/library/papers/2932467PubMed
2,420,496AMLR and MLR stimulating activity of human T lymphocytes activated in vitro by soluble HLA-DR antigens.Clin Exp Immunol1986https://conductscience.org/library/papers/2420496PubMed
311,475Absence of virus-induced lymphocyte suppression and interferon production in multiple sclerosis.Proc Natl Acad Sci U S A1979https://conductscience.org/library/papers/311475PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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