Paper70499
Plasmin inhibitor interactions. The effectiveness of alpha2-plasmin inhibitor in the presence of alpha2-macroglobulin.
Harpel PC. J Exp Med, 1977. Cited by 80 papers, by iCite.
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ConductScience Library. Plasmin inhibitor interactions. The effectiveness of alpha2-plasmin inhibitor in the presence of alpha2-macroglobulin. Papers, record 70499. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/70499
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- Plasmin inhibitor interactions. The effectiveness of alpha2-plasmin inhibitor in the presence of alpha2-macroglobulin.
- PubMed
Topics6
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Fibrinolysin | Major topic |
| alpha-Macroglobulins | Major topic |
| Binding, Competitive | |
| Electrophoresis, Polyacrylamide Gel | |
| Enzyme Inhibitors | |
| Humans |
Source PubMed
References19
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 123,251 | Studies on human plasma C1 inactivator-enzyme interactions. I. Mechanisms of interaction with C1s, plasmin, and trypsin. | J Clin Invest | 1975 | https://conductscience.org/library/papers/123251 | PubMed |
| 2 | 134,998 | Isolation and characterization of alpha2-plasmin inhibitor from human plasma. A novel proteinase inhibitor which inhibits activator-induced clot lysis. | J Biol Chem | 1976 | https://conductscience.org/library/papers/134998 | PubMed |
| 4 | 136,345 | Identification and some properties of a new fast-reacting plasmin inhibitor in human plasma. | Eur J Biochem | 1976 | https://conductscience.org/library/papers/136345 | PubMed |
| 5 | 13,654,273 | xi-Aminocaproic acid: an inhibitor of plasminogen activation. | J Biol Chem | 1959 | https://conductscience.org/library/papers/13654273 | PubMed |
| 6 | 137,718 | The primary inhibitor of plasmin in human plasma. | Biochem J | 1976 | https://conductscience.org/library/papers/137718 | PubMed |
| 8 | 4,160,044 | A method of trace iodination of proteins for immunologic studies. | Int Arch Allergy Appl Immunol | 1966 | https://conductscience.org/library/papers/4160044 | PubMed |
| 9 | 4,166,401 | Inhibition of plasmin activity by alpha-2-macroglobulin. | Clin Chim Acta | 1967 | https://conductscience.org/library/papers/4166401 | PubMed |
| 10 | 4,166,651 | Alpha-1-antitrypsin, an inhibitor for thrombin and plasmin. | Clin Chim Acta | 1967 | https://conductscience.org/library/papers/4166651 | PubMed |
| 11 | 4,178,758 | The inhibition of plasmin, plasma kallikrein, plasma permeability factor, and the C'1r subcomponent of the first component of complement by serum C'1 esterase inhibitor. | J Exp Med | 1969 | https://conductscience.org/library/papers/4178758 | PubMed |
| 12 | 4,224,456 | The plasmin inhibitor of human plasma. IV. Its action on plasmin, trypsin, chymotrypsin, and thrombin. | J Biol Chem | 1966 | https://conductscience.org/library/papers/4224456 | PubMed |
| 13 | 4,239,491 | Comparison of the esterase activities of trypsin, plasmin, and thrombin on guanidinobenzoate esters. Titration of the enzymes. | Biochemistry | 1969 | https://conductscience.org/library/papers/4239491 | PubMed |
| 14 | 4,269,529 | Degradation of human fibrinogen by plasms alpha2-macroglobulin-enzyme complexes. | J Clin Invest | 1973 | https://conductscience.org/library/papers/4269529 | PubMed |
| 15 | 4,269,767 | Isolation, characterization, and comparison of the S-carboxymethyl heavy (A) and light (B) chain derivatives of cat, dog, rabbit, and bovine plasmins. | J Biol Chem | 1973 | https://conductscience.org/library/papers/4269767 | PubMed |
| 16 | 4,276,455 | The inhibition of human plasmin by human antithrombin-heparin cofactor. | J Biol Chem | 1974 | https://conductscience.org/library/papers/4276455 | PubMed |
| 17 | 4,282,470 | Different molecular forms of plasminogen and plasmin produced by urokinase in human plasma and their relation to protease inhibitors and lysis of fibrinogen and fibrin. | Biochem J | 1974 | https://conductscience.org/library/papers/4282470 | PubMed |
| 18 | 5,475,635 | Plasminogen: purification from human plasma by affinity chromatography. | Science | 1970 | https://conductscience.org/library/papers/5475635 | PubMed |
| 19 | 5,806,584 | The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. | J Biol Chem | 1969 | https://conductscience.org/library/papers/5806584 | PubMed |
| 20 | 59,937 | Alpha 2-macroglobulin and antithrombin-heparin cofactor: modulators of hemostatic and inflammatory reactions. Alpha 2-macroglobulin. | Prog Hemost Thromb | 1976 | https://conductscience.org/library/papers/59937 | PubMed |
| 21 | 64,914 | Human alpha2-macroglobulin. | Methods Enzymol | 1976 | https://conductscience.org/library/papers/64914 | PubMed |
Cited by15
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 80 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 41,964,382 | Human α2-Macroglobulin: Architecture, Mechanisms, and Functional Implications. | FASEB J | 2026 | https://conductscience.org/library/papers/41964382 | PubMed |
| 39,628,652 | Enhanced thrombin and plasmin generation profiles in alpha-2-antiplasmin-deficient patients: Data from the Rare Bleeding disorders in the Netherlands study. | Res Pract Thromb Haemost | 2024 | https://conductscience.org/library/papers/39628652 | PubMed |
| 34,406,905 | Plasminogen activator receptor assemblies in cell signaling, innate immunity, and inflammation. | Am J Physiol Cell Physiol | 2021 | https://conductscience.org/library/papers/34406905 | PubMed |
| 7,693,593 | Alpha-2-macroglobulin functions as an inhibitor of fibrinolytic, clotting, and neutrophilic proteinases in sepsis: studies using a baboon model. | Infect Immun | 1993 | https://conductscience.org/library/papers/7693593 | PubMed |
| 7,510,477 | Identification of targeting proteinase for rat alpha 1-macroglobulin in vivo. Mast-cell tryptase is a major component of the alpha 1-macroglobulin-proteinase complex endocytosed into rat liver lysosomes. | Biochem J | 1994 | https://conductscience.org/library/papers/7510477 | PubMed |
| 6,542,111 | Physiological activation of plasminogen in full term newborn infants. | J Clin Pathol | 1984 | https://conductscience.org/library/papers/6542111 | PubMed |
| 6,204,637 | Covalent binding of proteinases in their reaction with alpha 2-macroglobulin. | Biochem J | 1980 | https://conductscience.org/library/papers/6204637 | PubMed |
| 6,178,757 | Catabolic pathways for streptokinase, plasmin, and streptokinase activator complex in mice. In vivo reaction of plasminogen activator with alpha 2-macroglobulin. | J Clin Invest | 1982 | https://conductscience.org/library/papers/6178757 | PubMed |
| 6,177,314 | Functional modifications of alpha 2-macroglobulin by primary amines. Kinetics of inactivation of alpha 2-macroglobulin by methylamine, and formation of anomalous complexes with trypsin. | Biochem J | 1982 | https://conductscience.org/library/papers/6177314 | PubMed |
| 6,166,634 | Alpha2-plasmin inhibitor and alpha2-macroglobulin-plasmin complexes in plasma. Quantitation by an enzyme-linked differential antibody immunosorbent assay. | J Clin Invest | 1981 | https://conductscience.org/library/papers/6166634 | PubMed |
| 2,475,424 | Detection of an alteration of the alpha 2-macroglobulin gene in a patient with chronic lung disease and serum alpha 2-macroglobulin deficiency. | Hum Genet | 1989 | https://conductscience.org/library/papers/2475424 | PubMed |
| 1,534,318 | Role of thrombin and plasmin in development of delayed hypersensitivity reaction in guinea pig skin. | Inflammation | 1992 | https://conductscience.org/library/papers/1534318 | PubMed |
| 156,364 | Inhibitory spectrum of alpha 2-plasmin inhibitor. | Proc Natl Acad Sci U S A | 1979 | https://conductscience.org/library/papers/156364 | PubMed |
| 156,196 | Congenital deficiency of alpha 2-plasmin inhibitor associated with severe hemorrhagic tendency. | J Clin Invest | 1979 | https://conductscience.org/library/papers/156196 | PubMed |
| 151,804 | The human plasma fibrinolytic system: regulation and control. | Mol Cell Biochem | 1978 | https://conductscience.org/library/papers/151804 | PubMed |
Genes3
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| A2M | 2 | PubTator's text mining | https://conductscience.org/library/genes/2 | NCBI Gene |
| PLG | 5,340 | PubTator's text mining | https://conductscience.org/library/genes/5340 | NCBI Gene |
| SERPINF2 | 5,345 | PubTator's text mining | https://conductscience.org/library/genes/5345 | NCBI Gene |
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- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
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- Comments and corrections
- Drugs
- Data
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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