Paper · 8454591

Transcriptional regulation of TSG6, a tumor necrosis factor- and interleukin-1-inducible primary response gene coding for a secreted hyaluronan-binding protein.

Lee TH and 3 others. J Biol Chem, 1993. Cited by 53 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Transcriptional regulation of TSG6, a tumor necrosis factor- and interleukin-1-inducible primary response gene coding for a secreted hyaluronan-binding protein. Papers, record 8454591. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8454591

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Transcriptional regulation of TSG6, a tumor necrosis factor- and interleukin-1-inducible primary response gene coding for a secreted hyaluronan-binding protein.; PubMed
Journal: J Biol Chem; PubMed
Year: 1993; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/8454591/; PubMed
The journal: https://conductscience.org/library/journal-index/2985121R; PubMed
Citations, by iCite: 53; iCite
Relative citation ratio, by iCite: 1.1; iCite
Revised in PubMed: 2022-03-17; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Lee TH	T H
2	Klampfer L	L
3	Shows TB	T B
4	Vilcek J	J

Source PubMed

Topics21

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Cell Adhesion Molecules	Major topic
Hyaluronic Acid	Major topic
Interleukin-1	Major topic
Transcription, Genetic	Major topic
Tumor Necrosis Factor-alpha	Major topic
Animals
Base Sequence
Blotting, Northern
Cell Line
Chloramphenicol O-Acetyltransferase
Chromosomes, Human, Pair 2
Cloning, Molecular
DNA
Fibroblasts
Gene Expression Regulation
HeLa Cells
Humans
Hybrid Cells
Mice
Molecular Sequence Data
Protein Binding

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
HG00333	NHGRI NIH HHS	United States	R01HG000333	PubMed and NIH	NIH RePORTER
R35CA49731	NCI NIH HHS	United States	R35CA049731	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by20

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 53 citations.

PMID	Title	Journal	Year	In Papers	Source
42,909,366	Reprogramming of Human Limbal Niche Progenitors.	Int J Med Sci	2026	https://conductscience.org/library/papers/42909366	PubMed
40,691,615	CD317 stabilizes TNFR1 and confers the anti-inflammatory functions of MSCs via NF-κB/TSG6 pathway.	Stem Cell Res Ther	2025	https://conductscience.org/library/papers/40691615	PubMed
38,019,897	A cohort-based study of host gene expression: tumor suppressor and innate immune/inflammatory pathways associated with the HIV reservoir size.	PLoS Pathog	2023	https://conductscience.org/library/papers/38019897	PubMed
35,563,807	Recent Advancements in Antifibrotic Therapies for Regression of Liver Fibrosis.	Cells	2022	https://conductscience.org/library/papers/35563807	PubMed
34,306,096	Proteomic Analysis Reveals Commonly Secreted Proteins of Mesenchymal Stem Cells Derived from Bone Marrow, Adipose Tissue, and Synovial Membrane to Show Potential for Cartilage Regeneration in Knee Osteoarthritis.	Stem Cells Int	2021	https://conductscience.org/library/papers/34306096	PubMed
30,811,458	Gonadotropin regulation of ankyrin-repeat and SOCS-box protein 9 (ASB9) in ovarian follicles and identification of binding partners.	PLoS One	2019	https://conductscience.org/library/papers/30811458	PubMed
30,061,606	Inhibition of glycosphingolipid synthesis reverses skin inflammation and hair loss in ApoE-/- mice fed western diet.	Sci Rep	2018	https://conductscience.org/library/papers/30061606	PubMed
29,853,820	Association between Plasma Pentraxin 3 Levels and Bone Mineral Density in Elderly Koreans: the Dong-gu Study.	J Korean Med Sci	2018	https://conductscience.org/library/papers/29853820	PubMed
27,044,744	The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions.	J Biol Chem	2016	https://conductscience.org/library/papers/27044744	PubMed
23,437,386	NF-κB-dependent role for cold-inducible RNA binding protein in regulating interleukin 1β.	PLoS One	2013	https://conductscience.org/library/papers/23437386	PubMed

1 to 10 of 20

See all 20 cited by

Genes10

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
CD44	960	PubTator's text mining	https://conductscience.org/library/genes/960	NCBI Gene
CEBPB	1,051	PubTator's text mining	https://conductscience.org/library/genes/1051	NCBI Gene
DCN	1,634	PubTator's text mining	https://conductscience.org/library/genes/1634	NCBI Gene
FOSB	2,354	PubTator's text mining	https://conductscience.org/library/genes/2354	NCBI Gene
HAPLN1	1,404	PubTator's text mining	https://conductscience.org/library/genes/1404	NCBI Gene
IL1A	3,552	PubTator's text mining	https://conductscience.org/library/genes/3552	NCBI Gene
IRF1	3,659	PubTator's text mining	https://conductscience.org/library/genes/3659	NCBI Gene
IRF2	3,660	PubTator's text mining	https://conductscience.org/library/genes/3660	NCBI Gene
TNF	7,124	PubTator's text mining	https://conductscience.org/library/genes/7124	NCBI Gene
TNFAIP6	7,130	PubTator's text mining	https://conductscience.org/library/genes/7130	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data1

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bank	Accession
GENBANK	L07295

Source GENBANK

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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