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Human Drugs & Veterinary Drugs - A Cost Comparison

Paul Chong

Walter Reed National Military ...
University of Virginia School ...

Julian Fine

Campbell University of Osteopa...
MGH Institute of Health Profes...

Ram Bala

Santa Clara University, Depart...
Kevin Shannon
Email: kmshannon1016@gmail.com

Health care economics and organizations

Drug Cost Comparison

Pharmacy alternatives

Home delivery services

Veterinary drug equivalents

15 October 2024

13 August 2025

16 August 2025

METHODS

Medicare Part D spending data for 2021 was obtained through the Center for Medicare and Medicaid Services (CMS) online portal to identify the 50 most common drugs by number of beneficiaries.[9]Medicare Part D Prescribers - by Geography and Drug. Centers for Medicare & Medicaid Services. https://data.cms.gov/provider-summary-by-type-of-service/medicare-part-d-prescribers/medicare-part-d-prescribers-by-geography-and-drug. Accessed May 14, 2024.

Veterinary drug costs per tablet were compiled from the respective pharmacy websites and calculated using 30-, 60-, and 90-count quantities from the respective pharmacy websites as applicable; consistency was maintained in only scraping analogous data for each drug formulation across pharmacies (ie. only tablets versus only capsules versus only eye drops, etc).

RESULTS

1800 Pet Meds had the same lowest cost for Famotidine 10 mg (figure 1).

Cost Comparison for Famotidine 10 mg

Figure 1 Cost comparison for Famotidine 10 mg

The lowest normalized drug cost per unit (calculated using prices for 90-day supply) was 0.4406 for Cost Plus Drugs, followed by DiRx at 0.5789 (p < .05). Cost Plus Drugs had a lower normalized drug cost per unit than both veterinary options (p < .05). Both Cost Plus Drugs and DiRx had lower normalized drug costs per unit than GoodRx at 0.7349 (p < .05). 1800 Pet Meds had the highest normalized drug cost per unit at 0.9062 (p < .05); there was no difference in the normalized drug cost per unit between DiRx, GoodRx, and Chewy (0.6557; p > .05) (figure 2).

Normalized Drug Cost Comparison

Figure 2 Normalized drug cost comparison

For 30-day supply costs, Chewy was the cheapest option for 30/41 drug dosages studied with Cost Plus Drugs being the most affordable option for 8/41 drug dosages. The lowest normalized drug cost per unit (calculated using prices for 30-day supply) was 0.4665 for Chewy, though there was no significant difference between Chewy and Cost Plus Drugs at 0.5270 (p > .05). Cost Plus Drugs had no significant difference in cost compared to 1800 Pet Meds (p = .0565), but was lower than the costs of GoodRx and DiRx (p < .05) (figure 3).

30-day Supply Cost Comparison

Figure 3 30-day supply cost comparison

There were no differences in normalized drug costs per unit (90-day supply) for antibiotics aside from 1800 Pet Meds as the most expensive option (N=9; p < .05) (figure 4).

Antibiotic Costs Analysis

Figure 4 Antibiotic costs analysis

From the sample of four ophthalmic medications (eye drops for glaucoma) that were explored, there was a wide range of drug costs for 90-day supply, with Chewy being the cheapest options for Latanoprost 0.005% 2.5 mL and Timolol Maleate 0.5% 5 mL, and Cost Plus Drugs being the cheapest alternative for Dorzolamide-Timolol 22.3/6.8 mg 10 mL and Dorzolamide 2% 10 mL (note, DiRx did not have Latanoprost or Timolol available) (figure 5).

Ophthalmic Medications Cost Comparison

Figure 5 Ophthalmic medications cost comparison

DISCUSSION

While works in the past have indicated that veterinary equivalents of human prescription drugs have lower costs,[8]Haque W, Chencheri S, Virnig BA, et al. Price Comparison of Human and Veterinary Formulations of Common Medications. JAMA Intern Med. 2022;182(11):1216–1218. doi:10.1001/jamainternmed.2022.3938 the results of this study suggest that this is not the case with the emergence of home delivery services such as Cost Plus Drugs and DiRx. Namely, Cost Plus Drugs consistently exceeded other veterinary and human retail providers in normalized drug cost per unit, representing a pertinent and remarkable development in the effort to counter rising healthcare expenditures and pharmaceutical costs.

CONCLUSION

These findings provide a pertinent and current update to the work of Haque et al from 2022, showing that recently-established human pharmacy online alternatives (namely, Cost Plus Drugs) provide affordable options for those in need and represent an addressal of the high costs of human pharmaceuticals when compared to veterinary drug costs.

References

(1) Keehan SP, Stone DA, Poisal JA, et al. National Health Expenditure Projections, 2016-25: Price Increases, Aging Push Sector To 20 Percent Of Economy. Health Aff (Millwood). 2017;36(3):553–563. doi:10.1377/hlthaff.2016.1627.

(2) Kesselheim AS, Avorn J, Sarpatwari A. The High Cost of Prescription Drugs in the United States: Origins and Prospects for Reform. JAMA. 2016;316(8):858–871. doi:10.1001/jama.2016.11237.

(3) Dusetzina SB, Huskamp HA, Qin X, Keating NL. Prescription Drug Spending in Fee-for-Service Medicare, 2008-2019. JAMA. 2022;328(15):1515-1522. doi:10.1001/jama.2022.17825

(4) Garg S. The "Economic Health" of U.S. Health Care and Role of Middlemen. Diabetes Technol Ther. 2020;22(2):136-141. doi:10.1089/dia.2019.0395

(5) Schumock GT, Li EC, Suda KJ, et al. National trends in prescription drug expenditures and projections for 2014 [published correction appears in Am J Health Syst Pharm. 2014 Sep 15;71(18):1532]. Am J Health Syst Pharm. 2014;71(6):482-499. doi:10.2146/ajhp130767

(6) Tichy EM, Hoffman JM, Tadrous M, et al. National trends in prescription drug expenditures and projections for 2024. Am J Health Syst Pharm. Published online April 24, 2024. doi:10.1093/ajhp/zxae105

(7) Scott K, Qureshi M, Cox P, Marshall C et al. A Structural Analysis of the FDA Green Book-Approved Veterinary Drugs and Roles in Human Medicine. J Med Chem. 2020;63(24):15449-15482. doi:10.1021/acs.jmedchem.0c01502

(8) Haque W, Chencheri S, Virnig BA, et al. Price Comparison of Human and Veterinary Formulations of Common Medications. JAMA Intern Med. 2022;182(11):1216–1218. doi:10.1001/jamainternmed.2022.3938

(9) Medicare Part D Prescribers - by Geography and Drug. Centers for Medicare & Medicaid Services. https://data.cms.gov/provider-summary-by-type-of-service/medicare-part-d-prescribers/medicare-part-d-prescribers-by-geography-and-drug. Accessed May 14, 2024.

(10) GoodRx [Internet]. Santa Monica, CA: GoodRx, inc; 2020 [cited May 14, 2024]. Available from https://www.goodrx.com

(11) DiRx [Internet]. East Brunswick, NJ: DiRx Inc; 2024 [cited May 14, 2024]. Available from: https://www.dirxhealth.com

(12) CostPlus Drug Company [Internet]. Dallas, TX: Mark Cuban Cost Plus Drug Company, PBC; 2024 [cited May 14, 2024]. Available from: https://costplusdrugs.com/medications/

(13) Chewy [Internet]. Plantation Beach, FL: Chewy inc; 2024 [cited May 14, 2024]. Available from: https://www.chewy.com

(14) 1800 Pet Meds [Internet]. Delray Beach, FL: Pet Med Express, inc; 2024 [cited May 14, 2024]. Available from: https://www.1800petmeds.com

(15) Sood S, Iskander M, Heilenbach N, Chen D, Al-Aswad LA. A Review of Cost-Effectiveness Analyses for Open Angle Glaucoma Management. J Glaucoma. 2023;32(8):619-630. doi:10.1097/IJG.0000000000002249

(16) Mission of Mark Cuban Cost Plus Drugs: Mark Cuban Cost Plus Drugs Company. Mission of Mark Cuban Cost Plus Drugs | Mark Cuban Cost Plus Drugs Company. Accessed June 21, 2024. https://costplusdrugs.com/mission/.

(17) Competition and Markets Authority. Competition in the supply of veterinary medicines: Market study final report. GOV.UK. Published 2024. Accessed June 23, 2025. Available from https://assets.publishing.service.gov.uk/

© 2026 by the authors. This article is published by ConductScience under the terms of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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