Disease · EFO_1001390
Peri-Implantitis
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. Peri-Implantitis. Diseases, record EFO_1001390. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/EFO_1001390
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
Drugs13
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| CHLORHEXIDINE GLUCONATE | CHEMBL4297088 | Small molecule | Phase 3 | ClinicalTrials.gov | 3 | 3 | 3 | Drugs and targets |
| MINOCYCLINE HYDROCHLORIDE | CHEMBL1200881 | Small molecule | Phase 3 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
| MINOCYCLINE | CHEMBL1434 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| TRICLOSAN | CHEMBL849 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| CURCUMIN | CHEMBL140 | Small molecule | Phase 1 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| INDOCYANINE GREEN | CHEMBL1646 | Small molecule | Phase 1 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| CHLORHEXIDINE | CHEMBL790 | Small molecule | Early phase 1 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
| HYDROGEN PEROXIDE | CHEMBL71595 | Small molecule | Early phase 1 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
| METRONIDAZOLE | CHEMBL137 | Small molecule | Unknown | ClinicalTrials.gov | 3 | 3 | 3 | Drugs and targets |
| AMOXICILLIN | CHEMBL1082 | Small molecule | Unknown | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
1 to 10 of 13
See all 13 drugsTargets2
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| MTNR1A | Melatonin receptor | 1 | Melatonin receptor agonist | Unknown | https://conductscience.org/library/genes/4543 | Drugs and targets |
| MTNR1B | Melatonin receptor | 1 | Melatonin receptor agonist | Unknown | https://conductscience.org/library/genes/4544 | Drugs and targets |
Trials16
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT02080403 | The Efficacy and Safety of Chlorhexidine Gluconate Chip (PerioChip®) in Therapy of Peri-implantitis | Phase 3 | 290 | 2021-06-23 | Peri-Implantitis | CHLORHEXIDINE GLUCONATE | Its record names the disease | ClinicalTrials.gov |
| NCT01079663 | The Efficacy and Safety of Chlorhexidine Gluconate Chip (Periochip®) in Therapy of Symptoms in Patients With Peri-implantitis | Phase 2 | 60 | 2021-06-15 | Peri-implantitis | CHLORHEXIDINE GLUCONATE | Its record names the disease | ClinicalTrials.gov |
| NCT00662532 | Antibiotic Study for Dental Implants | Phase 3 | 44 | 2010-05-27 | Periodontitis | MINOCYCLINE | Its record names the disease | ClinicalTrials.gov |
| NCT01539564 | Arestin - Use in Subjects With Peri-Implantitis | Phase 3 | 215 | Peri-Implantitis | MINOCYCLINE HYDROCHLORIDE | Its record names the disease | ClinicalTrials.gov | |
| NCT01517334 | Arestin - Use in Subjects With Peri-Implantitis (With Subgingival Microbiological Evaluation) | Phase 3 | 208 | Peri-Implantitis | MINOCYCLINE HYDROCHLORIDE | Its record names the disease | ClinicalTrials.gov | |
| NCT03191721 | Triclosan Toothpaste in the Maintenance Phase of Peri-implantitis Treatment. | Phase 3 | 102 | Peri-Implantitis, Periodontal Diseases | TRICLOSAN | Its record names the disease | ClinicalTrials.gov | |
| NCT05024760 | Antiseptic Effects on the Dental Implant Internal Surface Microbiome | Early phase 1 | 97 | Peri-Implantitis, Peri-implant Mucositis, Implant Infection, Dental Implant Failed | CHLORHEXIDINE, HYDROGEN PEROXIDE | Its record names the disease | ClinicalTrials.gov | |
| NCT07529444 | Microbiological Evaluation of the Effectiveness of Different Surface Decontamination Protocols for Dental Implants | Not applicable | 90 | Periimplant Diseases, Dental Implant Failure, Dental Implant Complications | CHLORHEXIDINE GLUCONATE, RIBOFLAVIN | Its record names the disease | ClinicalTrials.gov | |
| NCT05444218 | Surgical Access Combined With Systematically Administered Antibiotics in the Treatment of Peri-implantitis | Not applicable | 89 | Peri-Implantitis | AMOXICILLIN, METRONIDAZOLE | Its record names the disease | ClinicalTrials.gov | |
| NCT07500844 | Decontamination Methods in the Treatment of Peri-implantitis | Not applicable | 64 | Peri-implantitis | CHLORHEXIDINE, MIRAMISTIN | Its record names the disease | ClinicalTrials.gov |
1 to 10 of 16
See all 16 trialsComparisons in its trials5
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Treatment vs Control: deaths from any cause | 0 of 146 | 2 of 144 | 290 | NCT02080403 | Trial comparisons |
| Treatment vs Control: serious adverse events | 4 of 146 | 3 of 144 | 290 | NCT02080403 | Trial comparisons |
| Chlorhexidine Chip (Periochip®) vs Placebo Chip: deaths from any cause | 0 of 30 | 0 of 30 | 60 | NCT01079663 | Trial comparisons |
| Chlorhexidine Chip (Periochip®) vs Placebo Chip: serious adverse events | 0 of 30 | 2 of 30 | 60 | NCT01079663 | Trial comparisons |
| Minocycline HCl vs No Intervention: serious adverse events | 1 of 22 | 3 of 22 | 44 | NCT00662532 | Trial comparisons |
Papers from its trials25
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/EFO_1001390
GET https://conductscience.org/api/diseases/v1/EFO_1001390/papers?page=2