Disease · HP_0002901

Hypocalcemia

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. Hypocalcemia. Diseases, record HP_0002901. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0002901

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: Hypocalcemia; Open Targets
Open Targets ID: HP_0002901; Open Targets
Other names: Decreased calcium(2+) concentration, Decreased calcium(2+) level, Decreased calcium(2+) level in blood, Hypocalcaemia, Low blood calcium levels, Reduced calcium(2+) concentration, Reduced calcium(2+) level, Reduced calcium(2+) level in blood; Open Targets
MeSH: D006996; MeSH
NCI Thesaurus: C37973; NCI Thesaurus
Highest stage of its drugs: Approval, for 8 of its 15 drugs, from DailyMed, FDA, PMDA and TTD; Open Targets

Drugs15

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
CALCIUM GLUCONATE	CHEMBL2106119	Small molecule	Approval	DailyMed and FDA	11	3	3	Drugs and targets
CALCITRIOL	CHEMBL846	Small molecule	Approval	DailyMed	17	1	1	Drugs and targets
CALCIUM CHLORIDE	CHEMBL1200668	Small molecule	Approval	DailyMed	9	1	1	Drugs and targets
CALCIUM CARBONATE	CHEMBL1200539	Small molecule	Approval	PMDA	2	1	1	Drugs and targets
CHOLECALCIFEROL	CHEMBL1042	Small molecule	Approval	PMDA	2	1	1	Drugs and targets
DIHYDROTACHYSTEROL	CHEMBL2356023	Small molecule	Approval	TTD	1	0	0	Drugs and targets
MAGNESIUM CARBONATE	CHEMBL1200736	Small molecule	Approval	PMDA	1	0	0	Drugs and targets
PARATHYROID HORMONE	CHEMBL2108078	Protein	Approval	DailyMed	1	0	0	Drugs and targets
TERIPARATIDE	CHEMBL525610	Protein	Phase 3	ClinicalTrials.gov	3	3	3	Drugs and targets
CALCIUM	CHEMBL1200496	Small molecule	Phase 2	ClinicalTrials.gov	2	2	2	Drugs and targets

1 to 10 of 15

See all 15 drugs

Targets4

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
VDR	Vitamin D3 receptor	4	Vitamin D receptor agonist	Approval	https://conductscience.org/library/genes/7421	Drugs and targets
PTH1R	Parathyroid hormone/parathyroid hormone-related peptide receptor	2	Parathyroid hormone receptor agonist	Approval	https://conductscience.org/library/genes/5745	Drugs and targets
NR3C1	Glucocorticoid receptor	1	Glucocorticoid receptor agonist	Phase 2	https://conductscience.org/library/genes/2908	Drugs and targets
SERPINC1	Antithrombin-III	1	Antithrombin-III activator	Unknown	https://conductscience.org/library/genes/462	Drugs and targets

Trials13

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT05735015	PTH-independent Effects of Encaleret	Phase 2	13	2026-03-11	Post-Surgical Hypoparathyroidism	ENCALERET	Its record names the disease	ClinicalTrials.gov
NCT00623974	Teriparatide (Forteo) in the Treatment of Patients With Postoperative Hypocalcemia	Phase 2	7	2010-09-13	Hypocalcemia	CALCITRIOL, CALCIUM, TERIPARATIDE	Its record names the disease	ClinicalTrials.gov
NCT01171690	Teriparatide for Postsurgical Hypoparathyroidism	Phase 2	5	2014-12-22	Hypoparathyroidism Post-surgical	TERIPARATIDE	Its record names the disease	ClinicalTrials.gov
NCT06160479	The Incidence of Hypocalcemia in Pregnant Women at Siriraj Hospital	Not applicable	444		Hypocalcemia in Pregnancy	CALCIUM	Its record names the disease	ClinicalTrials.gov
NCT02021864	Vitamin D Treatment and Hypocalcemic Pregnant Women	Not applicable	120		Pregnancy Complications	CHOLECALCIFEROL	Its record names the disease	ClinicalTrials.gov
NCT04351438	Evaluation of Complication Rates Using Filter vs. Centrifuge and Heparin vs. Citrate Anticoagulation		108		Therapeutic Plasma Exchange, Anticoagulant Therapy	CITRIC ACID, HEPARIN	Its record names the disease	ClinicalTrials.gov
NCT05732883	The Use of Dexamethasone in Total Thyroidectomy to Improve Voice Outcome and Hypocalcaemia	Phase 2	100		Voice Change, Hypocalcemia	DEXAMETHASONE	Its record names the disease	ClinicalTrials.gov
NCT06820645	Calcium Administration in Life-saving Management During Massive Hemorrhage	Phase 2/3	81		Massive Hemorrhage, Trauma, Hypocalcemia	CALCIUM GLUCONATE	Its record names the disease	ClinicalTrials.gov
NCT06547151	Evaluating the Safety and Efficacy of AMOR-1 as a Treatment for Hypocalcemia Associated With Hypoparathyroidism in Adults	Phase 2	62		Hypoparathyroidism	CALCIUM CARBONATE	Its record names the disease	ClinicalTrials.gov
NCT00053378	A Study to Examine the Use of Zemplar to Increase Serum Calcium Levels in ICU Subjects	Phase 2	45		Hypocalcemia	PARICALCITOL	Its record names the disease	ClinicalTrials.gov

1 to 10 of 13

See all 13 trials

Comparisons in its trials1

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial
Teriparatide vs Control: serious adverse events	0 of 5	0 of 5	10	NCT01171690

Source Trial comparisons

Papers from its trials9

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
30678706	RESULT	1	PubMed
30670518	RESULT	1	PubMed
30220281	RESULT	1	PubMed
28146331	RESULT	1	PubMed
27896442	RESULT	1	PubMed
23394211	RESULT	1	PubMed
22532037	RESULT	1	PubMed
17722047	RESULT	1	PubMed
39077939	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/HP_0002901

GET https://conductscience.org/api/diseases/v1/HP_0002901/drugs

API reference For AI assistants