Disease · MONDO_0000257
acute diarrhea
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. acute diarrhea. Diseases, record MONDO_0000257. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0000257
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
- Other names
- acute diarrheal disease, diarrhea (disease), acute, diarrhea, acute, diarrheal disease, acute, diarrhoea (disease), acute
- Open Targets
Drugs11
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| RACECADOTRIL | CHEMBL2103772 | Small molecule | Phase 3 | ClinicalTrials.gov | 3 | 3 | 3 | Drugs and targets |
| LOPERAMIDE HYDROCHLORIDE | CHEMBL1707 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| SIMETHICONE | CHEMBL4297192 | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets | |
| ZINC GLUCONATE | CHEMBL3833377 | Small molecule | Phase 2/3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| ZINC SULFATE | CHEMBL1200929 | Small molecule | Phase 2 | ClinicalTrials.gov | 4 | 4 | 3 | Drugs and targets |
| BIFIDOBACTERIUM SPP. | CHEMBL4297912 | Phase 2 | ClinicalTrials.gov | 1 | 1 | 0 | Drugs and targets | |
| ZINC ACETATE | CHEMBL3184986 | Small molecule | Phase 1 | ClinicalTrials.gov | 1 | 1 | 0 | Drugs and targets |
| ANTIMONY | CHEMBL4297652 | Small molecule | Unknown | ClinicalTrials.gov | 1 | 1 | 0 | Drugs and targets |
| AZITHROMYCIN | CHEMBL529 | Small molecule | Unknown | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| HUMAN IMMUNOGLOBULIN G | CHEMBL1201599 | Unknown | ClinicalTrials.gov | 1 | 1 | 0 | Drugs and targets |
1 to 10 of 11
See all 11 drugsTargets4
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| MME | Neprilysin | 1 | Neprilysin inhibitor | Phase 3 | https://conductscience.org/library/genes/4311 | Drugs and targets |
| OPRM1 | Mu-type opioid receptor | 1 | Mu opioid receptor agonist | Phase 3 | https://conductscience.org/library/genes/4988 | Drugs and targets |
| TLR7 | Toll-like receptor 7 | 1 | Toll-like receptor 7 antagonist | Unknown | https://conductscience.org/library/genes/51284 | Drugs and targets |
| TLR9 | Toll-like receptor 9 | 1 | Toll-like receptor 9 antagonist | Unknown | https://conductscience.org/library/genes/54106 | Drugs and targets |
Trials9
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 2 more are not shown, since the checks do not confirm them.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT03463512 | Controlled Study to Evaluate the Efficacy and Safety of Racecadotril in Infants, Children and Adolescents With Acute Diarrhea | Phase 3 | 124 | 2019-10-23 | Diarrhea | RACECADOTRIL | Its record names the disease | ClinicalTrials.gov |
| NCT01198587 | Oral Zinc for the Treatment of Acute Diarrhea in US Children | Not applicable | 71 | 2018-08-22 | Diarrhea, Gastroenteritis | ZINC SULFATE | Its record names the disease | ClinicalTrials.gov |
| NCT01153854 | Safety, Efficacy and Cost-effectiveness of Racecadotril in Children With Acute Diarrhea in Mexico | Phase 3 | 454 | Diarrhea | RACECADOTRIL | Its record names the disease | ClinicalTrials.gov | |
| NCT00370968 | Zinc-ORS in Severe and Complicated Acute Diarrhea | Phase 2/3 | 352 | Diarrhea, Dehydration | ZINC GLUCONATE | Its record names the disease | ClinicalTrials.gov | |
| NCT04039828 | Zinc Sulfate Acceptability | Not applicable | 325 | Acute Diarrhea | ZINC SULFATE | Its record names the disease | ClinicalTrials.gov | |
| NCT01140074 | Efficacy of Zinc Sulfate With Probiotics for the Treatment of Acute Diarrhea in Children | Phase 2 | 256 | Acute Watery Diarrhoea | ZINC SULFATE | Its record names the disease | ClinicalTrials.gov | |
| NCT02340481 | Efficacy and Safety Study of Loperamide Hydrochloride/Simethicone Chewable Tablet in Treatment of Acute Diarrhea With Abdominal Discomfort and Flatulence | Phase 3 | 217 | Diarrhea | LOPERAMIDE HYDROCHLORIDE, SIMETHICONE | Its record names the disease | ClinicalTrials.gov | |
| NCT04368351 | Bacteriotherapy in the Treatment of COVID-19 | 70 | COVID, Pneumonia, Diarrhea | AZITHROMYCIN, HYDROXYCHLOROQUINE | Its record names the disease | ClinicalTrials.gov | ||
| NCT04885049 | Comparing the Efficacy of Anti-secretory Versus Oral Immunoglobulins for Reducing the Episodes of Diarrhea in Children | Not applicable | 60 | Diarrhea | RACECADOTRIL | Its record names the disease | ClinicalTrials.gov |
Comparisons in its trials4
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Racecadotril Plus Standard Treatment Oral Rehydration Solution vs ORS (Standard Treatment): Number of Recovered Subjects as Defined by Global Physician Assessment of Success at the End of Treatment | 62 of 62 | 60 of 62 | 124 | NCT03463512 | Trial comparisons |
| Racecadotril Plus Standard Treatment Oral Rehydration Solution vs ORS (Standard Treatment): Number of Recovered Subjects Per Treatment Group. | 62 of 62 | 58 of 62 | 124 | NCT03463512 | Trial comparisons |
| Racecadotril Plus Standard Treatment Oral Rehydration Solution vs ORS (Standard Treatment): deaths from any cause | 0 of 62 | 0 of 62 | 124 | NCT03463512 | Trial comparisons |
| Racecadotril Plus Standard Treatment Oral Rehydration Solution vs ORS (Standard Treatment): serious adverse events | 0 of 62 | 0 of 62 | 124 | NCT03463512 | Trial comparisons |
Papers from its trials6
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0000257
GET https://conductscience.org/api/diseases/v1/MONDO_0000257/drugs