Disease · MONDO_0000845

fibrous dysplasia

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. fibrous dysplasia. Diseases, record MONDO_0000845. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0000845

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: fibrous dysplasia; Open Targets
Open Targets ID: MONDO_0000845; Open Targets
Other names: Osteofibrous dysplasia, fibrous dysplasia of bone; Open Targets
Disease Ontology: DOID:0080031; Disease Ontology
MeSH: D005357; MeSH
NCI Thesaurus: C34609; NCI Thesaurus
Orphanet: ORPHA:249; Orphanet
Highest stage of its drugs: Phase 2/3, for 1 of its 4 drugs, from ClinicalTrials.gov; Open Targets

Drugs4

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
RISEDRONIC ACID	CHEMBL923	Small molecule	Phase 2/3	ClinicalTrials.gov	1	1	1	Drugs and targets
BUROSUMAB	CHEMBL3707326	Antibody	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
DENOSUMAB	CHEMBL1237023	Antibody	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
TOCILIZUMAB	CHEMBL1237022	Antibody	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets4

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
FDPS	Farnesyl pyrophosphate synthase	1	Farnesyl diphosphate synthase inhibitor	Phase 2/3	https://conductscience.org/library/genes/2224	Drugs and targets
FGF23	Fibroblast growth factor 23	1	Fibroblast growth factor 23 inhibitor	Phase 2	https://conductscience.org/library/genes/8074	Drugs and targets
IL6R	Interleukin-6 receptor subunit alpha	1	Interleukin-6 receptor alpha subunit inhibitor	Phase 2	https://conductscience.org/library/genes/3570	Drugs and targets
TNFSF11	Tumor necrosis factor ligand superfamily member 11	1	Tumor necrosis factor ligand superfamily member 11 inhibitor	Phase 2	https://conductscience.org/library/genes/8600	Drugs and targets

Trials4

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT05509595	Burosumab for Fibroblast Growth Factor-23 Mediated Hypophosphatemia in Fibrous Dysplasia	Phase 2	12	2026-02-02	Fibrous Dysplasia Of Bone	BUROSUMAB	Its record names the disease	ClinicalTrials.gov
NCT00445575	Effect of Risedronate on Bone Morbidity in Fibrous Dysplasia of Bone	Phase 2/3	80		Fibrous Dysplasia of Bone	RISEDRONIC ACID	Its record names the disease	ClinicalTrials.gov
NCT01791842	TOCILIZUMAB IN FIBROUS DYSPLASIA OF BONE	Phase 2	19		Fibrous Dysplasia of Bone	TOCILIZUMAB	Its record names the disease	ClinicalTrials.gov
NCT03571191	Denosumab Treatment for Fibrous Dysplasia	Phase 2	9		Bone Diseases, Pain	DENOSUMAB	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials4

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
35104665	RESULT	1	PubMed
41534675	DERIVED	1	PubMed
38378678	DERIVED	1	PubMed
36812441	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0000845

GET https://conductscience.org/api/diseases/v1/MONDO_0000845/drugs

API reference For AI assistants