Disease · MONDO_0001098
separation anxiety disorder
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. separation anxiety disorder. Diseases, record MONDO_0001098. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0001098
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
- Other names
Adult-Onset Separation Anxiety Disorder, Children's separation anxiety, Pediatric-Onset Separation Anxiety Disorder, SAD, adult separation anxiety, adult separation anxiety disorder, childhood separation anxiety, childhood separation anxiety disorder, separation anxiety, separation anxiety in childhood
- Open Targets
Drugs5
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| ESCITALOPRAM | CHEMBL1508 | Small molecule | Phase 3 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
| SERTRALINE | CHEMBL809 | Small molecule | Phase 3 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
| FLUOXETINE | CHEMBL41 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| FLUVOXAMINE | CHEMBL814 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| GUANFACINE HYDROCHLORIDE | CHEMBL1200494 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
Targets4
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| SLC6A4 | Sodium-dependent serotonin transporter | 4 | Serotonin transporter inhibitor | Phase 3 | https://conductscience.org/library/genes/6532 | Drugs and targets |
| ADRA2A | Adrenergic receptor alpha-2 | 1 | Adrenergic receptor alpha-2 agonist | Phase 2 | https://conductscience.org/library/genes/150 | Drugs and targets |
| ADRA2B | Adrenergic receptor alpha-2 | 1 | Adrenergic receptor alpha-2 agonist | Phase 2 | https://conductscience.org/library/genes/151 | Drugs and targets |
| ADRA2C | Adrenergic receptor alpha-2 | 1 | Adrenergic receptor alpha-2 agonist | Phase 2 | https://conductscience.org/library/genes/152 | Drugs and targets |
Trials5
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT00052078 | Child and Adolescent Anxiety Disorders (CAMS) | Phase 3 | 488 | 2017-04-25 | Anxiety Disorders, Social Phobia, Generalized Anxiety Disorder | SERTRALINE | Its record names the disease | ClinicalTrials.gov |
| NCT01470469 | SPD503 in Subjects Aged 6-17 Years With Generalized Anxiety Disorder (GAD), Separation Anxiety Disorder (SAD), or Social Phobia (SoP) | Phase 2 | 83 | 2014-05-23 | Generalized Anxiety Disorder (GAD), Anxiety, Separation, Phobia, Social | GUANFACINE HYDROCHLORIDE | Its record names the disease | ClinicalTrials.gov |
| NCT04598230 | Partners in Caring for Anxious Youth | Phase 3 | 468 | Anxiety, Separation, Anxiety, Generalized, Anxiety, Social | ESCITALOPRAM, FLUOXETINE, SERTRALINE | Its record names the disease | ClinicalTrials.gov | |
| NCT01293838 | Cipralex® for Anxiety Disorders in Adolescents | Phase 1 | 30 | Anxiety Disorder | ESCITALOPRAM | Its record names the disease | ClinicalTrials.gov | |
| NCT00000389 | Treatment for Anxiety in Children | Phase 3 | Obsessive-Compulsive Disorder, Anxiety Disorders, Generalized Anxiety Disorder, Social Phobia, Separation Anxiety | FLUVOXAMINE | Its record names the disease | ClinicalTrials.gov |
Comparisons in its trials1
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial |
|---|---|---|---|---|
| SPD503 vs PLACEBO: serious adverse events | 0 of 62 | 0 of 21 | 83 | NCT01470469 |
Source Trial comparisons
Papers from its trials23
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0001098
GET https://conductscience.org/api/diseases/v1/MONDO_0001098/papers?page=2