Disease · MONDO_0002269

gastroenteritis

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. gastroenteritis. Diseases, record MONDO_0002269. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0002269

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: gastroenteritis; Open Targets
Open Targets ID: MONDO_0002269; Open Targets
Other names: inflammation of intestine, intestine inflammation; Open Targets
Disease Ontology: DOID:2326; Disease Ontology
MeSH: D005759; MeSH
NCI Thesaurus: C34632; NCI Thesaurus
Highest stage of its drugs: Phase 3, for 3 of its 8 drugs, from ClinicalTrials.gov; Open Targets

Drugs8

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
ONDANSETRON	CHEMBL46	Small molecule	Phase 3	ClinicalTrials.gov	4	4	4	Drugs and targets
PRULIFLOXACIN	CHEMBL422648	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
METOCLOPRAMIDE	CHEMBL86	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
DEXTROSE	CHEMBL1222250	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
POLYETHYLENE GLYCOL	CHEMBL1201478	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
SODIUM CHLORIDE	CHEMBL1200574	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
TANNIC ACID	CHEMBL506247		Phase 1	ClinicalTrials.gov	1	1	0	Drugs and targets
GRANISETRON	CHEMBL289469	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets3

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
HTR3A	5-hydroxytryptamine receptor 3A	3	Serotonin 3a (5-HT3a) receptor antagonist	Phase 3	https://conductscience.org/library/genes/3359	Drugs and targets
DRD2	D(2) dopamine receptor	1	Dopamine D2 receptor antagonist	Phase 3	https://conductscience.org/library/genes/1813	Drugs and targets
HTR4	5-hydroxytryptamine receptor 4	1	Serotonin 4 (5-HT4) receptor agonist	Phase 3	https://conductscience.org/library/genes/3360	Drugs and targets

Trials8

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT01285713	IV Glucose for Dehydration Treatment	Phase 2	83	2013-01-23	Dehydration	DEXTROSE, SODIUM CHLORIDE	Its record names the disease	ClinicalTrials.gov
NCT03851835	Multi-DOSE Oral Ondansetron for Pediatric Acute GastroEnteritis	Phase 3	1,030		Acute Gastroenteritis, Viral Illness, Vomiting, Diarrhea	ONDANSETRON	Open Targets' reading, confirmed by NLM's indexing of its papers	ClinicalTrials.gov
NCT00392574	Safety and Efficacy of Prulifloxacin Versus Placebo in Traveler's Diarrhea	Phase 3	282		Acute Gastroenteritis in Adult Travelers	PRULIFLOXACIN	Its record names the disease	ClinicalTrials.gov
NCT00448422	Safety and Efficacy of Prulifloxacin vs Placebo in Treatment of Acute Gastroenteritis in Adult Travelers	Phase 3	268		Acute Bacterial Gastroenteritis	PRULIFLOXACIN	Open Targets' reading of its record	ClinicalTrials.gov
NCT02619201	Antiemetic Efficacy of Ondansetron Versus Metoclopramide	Phase 3	250		Acute Gastroenteritis, Vomiting	METOCLOPRAMIDE, ONDANSETRON	Open Targets' reading of its record	ClinicalTrials.gov
NCT06175806	Granisetron Versus Ondansetron for Nausea and Vomiting in Pediatric Age Group	Not applicable	160		Nausea and Vomiting in Pediatric Age Group	GRANISETRON, ONDANSETRON	Its record names the disease	ClinicalTrials.gov
NCT04458129	Polyethylene Glycol and Intestinal Inflammation in Cystic Fibrosis	Phase 2	23		Cystic Fibrosis	POLYETHYLENE GLYCOL	Open Targets' reading of its record	ClinicalTrials.gov
NCT00120744	Oral Disintegrating Ondansetron Tablet to Reduce Vomiting From Gastroenteritis in a Pediatric Emergency Department	Not applicable			Gastroenteritis, Vomiting, Diarrhea, Dehydration	ONDANSETRON	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials1

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial
D5Normal Saline vs Normal Saline: serious adverse events	0 of 41	0 of 42	83	NCT01285713

Source Trial comparisons

Papers from its trials4

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
42090154	DERIVED	1	PubMed
40673584	DERIVED	1	PubMed
32838813	DERIVED	1	PubMed
32460879	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0002269

GET https://conductscience.org/api/diseases/v1/MONDO_0002269/drugs

API reference For AI assistants