Drug · CHEMBL86
METOCLOPRAMIDE
7 sourcespipelines-2026-09-18-0.3.1
Cite this record
ConductScience Library. METOCLOPRAMIDE. Drugs and targets, record CHEMBL86. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL86
On this page
Drug
Names and IDs as ChEMBL gives them, through Open Targets.
Targets3
The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.
| Target | Protein | Mechanism | Action | Gene in Genes |
|---|---|---|---|---|
| DRD2 | D(2) dopamine receptor | Dopamine D2 receptor antagonist | ANTAGONIST | https://conductscience.org/library/genes/1813 |
| HTR3A | 5-hydroxytryptamine receptor 3A | Serotonin 3a (5-HT3a) receptor antagonist | ANTAGONIST | https://conductscience.org/library/genes/3359 |
| HTR4 | 5-hydroxytryptamine receptor 4 | Serotonin 4 (5-HT4) receptor agonist | AGONIST | https://conductscience.org/library/genes/3360 |
Source ChEMBL
Diseases30
The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
1 to 10 of 30Source Open Targets
See all 30 diseasesTrials140
Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs.
| Trial | Title | Phase | Participants | Results first posted | Named as | Linked by | Source |
|---|---|---|---|---|---|---|---|
| NCT02625181 | Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis | 27,034 | 2019-03-07 | metoclopramide | Its name | ClinicalTrials.gov | |
| NCT00682734 | Metoclopramide for Migraine: A Dose Finding Study | Phase 3 | 349 | 2012-12-31 | metoclopramide | Its name | ClinicalTrials.gov |
| NCT01267864 | Valproate Versus Ketorolac Versus Metoclopramide | Phase 4 | 330 | 2018-06-04 | metoclopramide | Its name | ClinicalTrials.gov |
| NCT01216410 | Prevention of Intraoperative Nausea and Vomiting During Cesarean Section | 306 | 2013-03-25 | metoclopramide | Its name | ClinicalTrials.gov | |
| NCT00395161 | The CRISIS Prevention Study | Phase 3 | 293 | 2013-04-18 | metoclopramide | Its name | ClinicalTrials.gov |
| NCT00475306 | The Montefiore Metoclopramide Study | Phase 4 | 289 | 2012-12-31 | metoclopramide | Its name | ClinicalTrials.gov |
| NCT00845858 | Efficacy and Safety of Metoclopramide Nasal Spray Solution in Diabetic Patients With Gastroparesis | Phase 2 | 287 | 2014-06-17 | metoclopramide | Its name | ClinicalTrials.gov |
| NCT02847494 | Corticosteroids for Acute Migraine in the Emergency Department | Phase 4 | 220 | 2019-01-08 | metoclopramide | Its name | ClinicalTrials.gov |
| NCT01825941 | Diphenhydramine for Acute Migraine | Phase 4 | 208 | 2018-06-08 | metoclopramide | Its name | ClinicalTrials.gov |
| NCT02025725 | Multicenter Study to Evaluate the Efficacy and Safety of Metoclopramide Nasal Spray in Women With Diabetic Gastroparesis | Phase 3 | 205 | 2020-02-11 | metoclopramide | Its name | ClinicalTrials.gov |
1 to 10 of 140
See all 140 trialsComparisons in its trials61
Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide vs Enteral Whey Protein, IV Saline: Incidence of Prolonged Lymphopenia (Absolute Lymphocyte Count Less Than or Equal to 1,000/mm³ for > or Equal to 7 Days) | 5 of 149 | 12 of 144 | 293 | NCT00395161 | Trial comparisons |
| Daily Nutriceutical Supplementation vs Whey Protein: serious adverse events | 73 of 148 | 70 of 139 | 287 | NCT00395161 | Trial comparisons |
| Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide vs Enteral Whey Protein, IV Saline: All-cause 28-day Mortality Rate. | 15 of 145 | 8 of 139 | 284 | NCT00395161 | Trial comparisons |
| Experimental vs Control: deaths from any cause | 0 of 111 | 0 of 109 | 220 | NCT02847494 | Trial comparisons |
| Experimental vs Control: serious adverse events | 0 of 111 | 0 of 109 | 220 | NCT02847494 | Trial comparisons |
| Experimental vs Control: Number of Participants With Sustained Headache Freedom | 6 of 110 | 10 of 107 | 217 | NCT02847494 | Trial comparisons |
| Metoclopramide + Diphenhydramine vs Metoclopramide + Placebo: deaths from any cause | 0 of 104 | 0 of 104 | 208 | NCT01825941 | Trial comparisons |
| Metoclopramide + Diphenhydramine vs Metoclopramide + Placebo: serious adverse events | 0 of 104 | 0 of 103 | 207 | NCT01825941 | Trial comparisons |
| Experimental vs Control: Medication Preference as Assessed by Self-report | 75 of 106 | 76 of 101 | 207 | NCT02847494 | Trial comparisons |
| 10 mg Metoclopramide Nasal Spray vs Placebo Nasal Spray: deaths from any cause | 0 of 102 | 0 of 103 | 205 | NCT02025725 | Trial comparisons |
1 to 10 of 61
See all 61 comparisons in its trialsPapers from its trials88
The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Tests in its trials0
The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.
None in this release.
Data dates
The date of each source this release read.
Sources 7
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ConductCognition's list of its testsOur own data
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this drug from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/drugs/v1/CHEMBL86
GET https://conductscience.org/api/drugs/v1/CHEMBL86/diseases?page=2