Disease · MONDO_0007293

leukocyte adhesion deficiency 1

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. leukocyte adhesion deficiency 1. Diseases, record MONDO_0007293. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0007293

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: leukocyte adhesion deficiency 1; Open Targets
Open Targets ID: MONDO_0007293; Open Targets
Other names: ITGB2 leukocyte adhesion deficiency, LAD-I, LAD1, LFA-I deficiency, LFA1 immunodeficiency, lad-type I, leukocyte adhesion deficiency caused by mutation in ITGB2, leukocyte adhesion deficiency type 1, leukocyte adhesion deficiency type I, lymphocyte function-associated antigen 1 immunodeficiency; Open Targets
Disease Ontology: DOID:0110910; Disease Ontology
MeSH: C535887; MeSH
NCI Thesaurus: C4689; NCI Thesaurus
Orphanet: ORPHA:99842; Orphanet
Highest stage of its drugs: Phase 2, for 4 of its 6 drugs, from ClinicalTrials.gov; Open Targets

Drugs6

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
ALEMTUZUMAB	CHEMBL1201587	Antibody	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
FLUDARABINE	CHEMBL1568	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
INTERFERON GAMMA-1B	CHEMBL1201564	Protein	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
MELPHALAN	CHEMBL852	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
USTEKINUMAB	CHEMBL1201835	Antibody	Phase 1/2	ClinicalTrials.gov	1	1	1	Drugs and targets
MARNETEGRAGENE AUTOTEMCEL	CHEMBL4802256	Gene	Phase 1/2	TTD	1	0	0	Drugs and targets

Targets6

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
CD52	CAMPATH-1 antigen	1	CAMPATH-1 antigen inhibitor	Phase 2	https://conductscience.org/library/genes/1043	Drugs and targets
IFNGR1	Interferon gamma receptor	1	Interferon gamma receptor agonist	Phase 2	https://conductscience.org/library/genes/3459	Drugs and targets
IFNGR2	Interferon gamma receptor	1	Interferon gamma receptor agonist	Phase 2	https://conductscience.org/library/genes/3460	Drugs and targets
IL12A	Interleukin-12	1	Interleukin-12 inhibitor	Phase 1/2	https://conductscience.org/library/genes/3592	Drugs and targets
IL12B	Interleukin-12	1	Interleukin-12 inhibitor; Interleukin-23 inhibitor	Phase 1/2	https://conductscience.org/library/genes/3593	Drugs and targets
IL23A	Interleukin-23	1	Interleukin-23 inhibitor	Phase 1/2	https://conductscience.org/library/genes/51561	Drugs and targets

Trials3

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT01998633	Reduced Intensity Conditioning for Hemophagocytic Syndromes or Selected Primary Immune Deficiencies (BMT CTN 1204)	Phase 2	47	2018-06-01	Hemophagocytic Lymphohistiocytosis, Chronic Active Epstein-Barr Virus Infection, Chronic Granulomatous Disease, HIGM-1, Leukocyte Adhesion Deficiency, IPEX	ALEMTUZUMAB, FLUDARABINE, MELPHALAN	Its record names the disease	ClinicalTrials.gov
NCT03366142	Ustekinumab (Anti-IL-12/23p40 Monoclonal Antibody) in Patients With Leukocyte Adhesion Deficiency Type 1 (LAD1) Who Have Inflammatory Pathology	Phase 1/2	6		LAD1	USTEKINUMAB	Its record names the disease	ClinicalTrials.gov
NCT00001905	Interferon Gamma to Treat Leukocyte Adhesion Deficiency Type I	Phase 2	5		Leukocyte Adhesion Deficiency Syndrome	INTERFERON GAMMA-1B	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials1

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it
37042921	DERIVED	1

Source PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0007293

GET https://conductscience.org/api/diseases/v1/MONDO_0007293/drugs

API reference For AI assistants