Disease · MONDO_0016587
arrhythmogenic right ventricular cardiomyopathy
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. arrhythmogenic right ventricular cardiomyopathy. Diseases, record MONDO_0016587. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0016587
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
- Other names
ARVC, ARVD, ARVD/C, Arrhythmogenic right ventricular cardiomyopathy (disorder), Arrhythmogenic right ventricular dysplasia/cardiomyopathy, arrhythmogenic RVD, arrhythmogenic right ventricular dysplasia, right ventricular dysplasia
- Open Targets
Drugs3
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| FLECAINIDE | CHEMBL652 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| SPIRONOLACTONE | CHEMBL1393 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| TIDEGLUSIB | CHEMBL3545157 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
Targets3
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| GSK3B | Glycogen synthase kinase-3 beta | 1 | Glycogen synthase kinase-3 beta inhibitor | Phase 2 | https://conductscience.org/library/genes/2932 | Drugs and targets |
| NR3C2 | Mineralocorticoid receptor | 1 | Mineralocorticoid receptor antagonist | Phase 2 | https://conductscience.org/library/genes/4306 | Drugs and targets |
| SCN5A | Sodium channel protein type 5 subunit alpha | 1 | Sodium channel protein type V alpha subunit blocker | Phase 2 | https://conductscience.org/library/genes/6331 | Drugs and targets |
Trials3
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT03685149 | Pilot Randomized Trial With Flecainide in ARVC Patients | Phase 2 | 22 | 2024-08-20 | Arrhythmogenic Right Ventricular Cardiomyopathy | FLECAINIDE | Its record names the disease | ClinicalTrials.gov |
| NCT03593317 | Blockade of the Renin-angiotensin-aldosterone System in Patients With ARVD | Phase 2 | 120 | Arrhythmogenic Right Ventricular Dysplasia | SPIRONOLACTONE | Its record names the disease | ClinicalTrials.gov | |
| NCT06174220 | Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy | Phase 2 | 120 | Arrhythmogenic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy | TIDEGLUSIB | Its record names the disease | ClinicalTrials.gov |
Comparisons in its trials3
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Flecainide vs Placebo: deaths from any cause | 0 of 22 | 0 of 22 | 44 | NCT03685149 | Trial comparisons |
| Flecainide vs Placebo: serious adverse events | 1 of 22 | 1 of 22 | 44 | NCT03685149 | Trial comparisons |
| Flecainide vs Placebo: Number of Participants With Proarrhythmic Response to Flecainide | 3 of 19 | 3 of 19 | 38 | NCT03685149 | Trial comparisons |
Papers from its trials1
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
| PMID | Listed as | Trials listing it |
|---|---|---|
| 37979797 | DERIVED | 2 |
Source PubMed
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0016587
GET https://conductscience.org/api/diseases/v1/MONDO_0016587/drugs