Disease · MONDO_0850098

oligoasthenoteratozoospermia

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. oligoasthenoteratozoospermia. Diseases, record MONDO_0850098. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0850098

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: oligoasthenoteratozoospermia; Open Targets
Open Targets ID: MONDO_0850098; Open Targets
Disease Ontology: DOID:0070311; Disease Ontology
Highest stage of its drugs: Phase 2, for 2 of its 14 drugs, from ClinicalTrials.gov; Open Targets

Drugs14

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
CALCITRIOL	CHEMBL846	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
ISOTRETINOIN	CHEMBL547	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
ACETYLCARNITINE	CHEMBL1697733	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
ASCORBIC ACID	CHEMBL196	Small molecule	Unknown	ClinicalTrials.gov	1	1	0	Drugs and targets
CARNITINE	CHEMBL172513	Small molecule	Unknown	ClinicalTrials.gov	1	1	0	Drugs and targets
CITRIC ACID	CHEMBL1261	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
FOLIC ACID	CHEMBL1622	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
FRUCTOSE	CHEMBL1232863	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
LEVOCARNITINE	CHEMBL1149	Small molecule	Unknown	ClinicalTrials.gov	1	1	0	Drugs and targets
SELENIUM	CHEMBL6068503	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

1 to 10 of 14

See all 14 drugs

Targets4

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
RARA	Retinoic acid receptor	1	Retinoic acid receptor agonist	Phase 2	https://conductscience.org/library/genes/5914	Drugs and targets
RARB	Retinoic acid receptor	1	Retinoic acid receptor agonist	Phase 2	https://conductscience.org/library/genes/5915	Drugs and targets
RARG	Retinoic acid receptor	1	Retinoic acid receptor agonist	Phase 2	https://conductscience.org/library/genes/5916	Drugs and targets
VDR	Vitamin D3 receptor	1	Vitamin D receptor agonist	Phase 2	https://conductscience.org/library/genes/7421	Drugs and targets

Trials2

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT02061384	RA-2 13-cis Retinoic Acid (Isotretinoin)	Phase 2	20	2021-07-30	Male Infertility, Klinefelter's Syndrome, Y-chromosome Microdeletions	CALCITRIOL, ISOTRETINOIN	Its record names the disease	ClinicalTrials.gov
NCT06042738	Investigation of The Effectiveness of Antioxidant Therapy in Oligoasthenoteratozoospermic Infertile Men	Not applicable	48		Male Infertility	ACETYLCARNITINE, CITRIC ACID, FOLIC ACID, FRUCTOSE, SELENIUM, UBIDECARENONE, VITAMIN B12	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials2

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
13-cis Retinoic Acid + Oral Calcitriol vs 13-cis Retinoic Acid: deaths from any cause	0 of 10	0 of 10	20	NCT02061384	Trial comparisons
13-cis Retinoic Acid + Oral Calcitriol vs 13-cis Retinoic Acid: serious adverse events	0 of 10	0 of 10	20	NCT02061384	Trial comparisons

Papers from its trials1

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it
39536246	DERIVED	1

Source PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0850098

GET https://conductscience.org/api/diseases/v1/MONDO_0850098/drugs

API reference For AI assistants