Drug · CHEMBL656
OXYCODONE
7 sourcespipelines-2026-09-18-0.3.1
Cite this record
ConductScience Library. OXYCODONE. Drugs and targets, record CHEMBL656. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL656
On this page
Drug
Names and IDs as ChEMBL gives them, through Open Targets.
- Other names
(-)-14-hydroxydihydrocodeinone, 14-hydroxydihydrocodeinone, Dihydrone, IDS-NO-002, N02AA05, NSC-19043, Oxicodona, Oxicone, Oxycodone cii, Oxymorphone 3-methyl ether, PF-00345439, PTI-821, Pavinal, Pti 821, Remoxy, Xtampza
- ChEMBL
- Open Targets' highest stage
- Approval, for 3 of its 36 diseases, from ATC, DailyMed and TTD
- Open Targets
Targets1
The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.
| Target | Protein | Mechanism | Action | Gene in Genes |
|---|---|---|---|---|
| OPRM1 | Mu-type opioid receptor | Mu opioid receptor agonist | AGONIST | https://conductscience.org/library/genes/4988 |
Source ChEMBL
Diseases36
The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
1 to 10 of 36Source Open Targets
See all 36 diseasesTrials376
Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs. 1 more rests on that reading alone and is shown because the trial's posted result groups or NLM's indexing of its papers name the drug. 8 more that Open Targets linked to it are not shown, since the release's checks do not confirm them.
| Trial | Title | Phase | Participants | Results first posted | Named as | Linked by | Source |
|---|---|---|---|---|---|---|---|
| NCT02625181 | Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis | 27,034 | 2019-03-07 | oxycodone | Its name | ClinicalTrials.gov | |
| NCT04296396 | Opioid Prescription After Cesarean Trial | Phase 3 | 5,521 | 2023-10-03 | oxycodone | Its name | ClinicalTrials.gov |
| NCT00361504 | A Study to Evaluate Long-Term Safety of Multiple Doses of Tapentadol (CG5503) Prolonged-Release (PR) and Oxycodone Controlled-Release (CR) in Patients With Chronic Pain | Phase 3 | 1,123 | 2009-09-04 | oxycodone | Its name | ClinicalTrials.gov |
| NCT01358526 | Efficacy and Safety of Oxycodone/Naloxone Controlled-release Tablets (OXN) Compared to Placebo in Opioid-experienced Subjects With Moderate to Severe Chronic Low Back Pain | Phase 3 | 1,095 | 2014-09-03 | oxycodone | Its name | ClinicalTrials.gov |
| NCT00421928 | Tapentadol (CG5503) | Phase 3 | 1,030 | 2010-04-23 | oxycodone | Its name | ClinicalTrials.gov |
| NCT00449176 | A Study to Evaluate the Effectiveness and Safety of Tapentadol (CG5503) Extended Release (ER) in Patients With Moderate to Severe Chronic Low Back Pain | Phase 3 | 981 | 2010-06-24 | oxycodone | Its name | ClinicalTrials.gov |
| NCT00613938 | A Study to Evaluate the Effectiveness and Safety of Tapentadol (CG5503) in the Treatment of Acute Pain From Bunionectomy. | Phase 3 | 901 | 2010-04-23 | oxycodone | Its name | ClinicalTrials.gov |
| NCT01685684 | Oxycodone DETERx™ Versus Placebo in Chronic Low Back Pain (CLBP) | Phase 3 | 740 | 2017-02-23 | oxycodone | Its name | ClinicalTrials.gov |
| NCT01402375 | Comparing the Efficacy of Oral Opioids for Outpatient Acute Pain Management After ED Discharge Discharge | Phase 3 | 720 | 2018-05-01 | oxycodone | Its name | ClinicalTrials.gov |
| NCT00986180 | NUCYNTA (Tapentadol Immediate Release) Versus Oxycodone Immediate Release in the Treatment of Acute Low Back Pain | Phase 3 | 667 | 2012-02-29 | oxycodone | Its name | ClinicalTrials.gov |
1 to 10 of 376
See all 376 trialsComparisons in its trials106
Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Individualized Opioid Prescription (IOPP) -Neonates/Infants vs Fixed Opioid Prescription - Neonates/Infants: Infant Hospital Readmissions | 59 of 2,754 | 63 of 2,793 | 5,547 | NCT04296396 | Trial comparisons |
| Individualized Opioid Prescription vs Fixed Opioid Prescription: Number of Participants Who Filled One or More Opioid Prescriptions Beyond the Amount Prescribed at Discharge | 200 of 2,654 | 166 of 2,696 | 5,350 | NCT04296396 | Trial comparisons |
| Individualized Opioid Prescription vs Fixed Opioid Prescription: Number of Participants With Worst Pain Score of Moderate to Severe on the Brief Pain Inventory | 1,497 of 2,518 | 1,535 of 2,553 | 5,071 | NCT04296396 | Trial comparisons |
| Individualized Opioid Prescription Protocol (IOPP) vs Fixed Opioid Prescription: Number of Participants Who Indicated an Improved Global Impression of Change | 2,436 of 2,528 | 2,436 of 2,509 | 5,037 | NCT04296396 | Trial comparisons |
| Individualized Opioid Prescription Protocol (IOPP) vs Fixed Opioid Prescription: Pain Interference Score ≥ 4 at 2 Weeks Post Discharge | 415 of 2,514 | 427 of 2,486 | 5,000 | NCT04296396 | Trial comparisons |
| Individualized Opioid Prescription Protocol (IOPP) vs Fixed Opioid Prescription: Maternal Depression Score ≥ 13 | 185 of 2,496 | 191 of 2,496 | 4,992 | NCT04296396 | Trial comparisons |
| Tapentadol (CG5503) vs Oxycodone: Number of Participants With Treatment-emergent Adverse Events (TEAE) | 766 of 894 | 202 of 223 | 1,117 | NCT00361504 | Trial comparisons |
| Tapentadol (CG5503) vs Oxycodone: serious adverse events | 49 of 894 | 9 of 223 | 1,117 | NCT00361504 | Trial comparisons |
| NUCYNTA vs Oxycodone IR: Summary of Subjects Having Nausea as a Treatment-Emergent Adverse Event | 51 of 321 | 67 of 324 | 645 | NCT00986180 | Trial comparisons |
| NUCYNTA vs Oxycodone IR: Summary of Subjects Having Constipation as a Treatment-Emergent Adverse Event | 7 of 321 | 23 of 324 | 645 | NCT00986180 | Trial comparisons |
1 to 10 of 106
See all 106 comparisons in its trialsPapers from its trials123
The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Tests in its trials5
The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.
| Test | Trials naming it as an outcome | As a primary outcome | Source |
|---|---|---|---|
| Symbol Coding | 3 | 0 | ConductCognition |
| Stroop Color-Word Test | 1 | 0 | ConductCognition |
| Trail Making Test A | 1 | 0 | ConductCognition |
| Trail Making Test B | 1 | 0 | ConductCognition |
| Verbal Learning | 1 | 0 | ConductCognition |
Data dates
The date of each source this release read.
Sources 7
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ConductCognition's list of its testsOur own data
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this drug from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/drugs/v1/CHEMBL656
GET https://conductscience.org/api/drugs/v1/CHEMBL656/diseases?page=2