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Paper · 12912907

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.

Berra E and 5 others. EMBO J, 2003. Cited by 1,153 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. Papers, record 12912907. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/12912907

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.
PubMed
Journal
EMBO J
PubMed
Year
2003
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
1,153
iCite
Relative citation ratio, by iCite
23.2
iCite
Revised in PubMed
2024-01-04
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Berra EEdurne
2Benizri EEmmanuel
3Ginouvès AAmandine
4Volmat VVéronique
5Roux DDanièle
6Pouysségur JJacques

Source PubMed

Topics26

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
DNA-Binding ProteinsMajor topic
Immediate-Early ProteinsMajor topic
Nuclear ProteinsMajor topic
OxygenMajor topic
Procollagen-Proline DioxygenaseMajor topic
Transcription FactorsMajor topic
Biological Transport
Cell Hypoxia
Cell Line
Cell Nucleus
Dose-Response Relationship, Drug
Gene Silencing
HeLa Cells
Humans
Hydroxylation
Hypoxia
Hypoxia-Inducible Factor 1
Hypoxia-Inducible Factor 1, alpha Subunit
Hypoxia-Inducible Factor-Proline Dioxygenases
Isoenzymes
RNA, Messenger
RNA, Small Interfering
Recombinant Proteins
Transfection
Tumor Cells, Cultured
Up-Regulation

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References49

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
12,390,488Establishment and characterisation of a new tumorigenic cell line with a normal karyotype derived from a human breast adenocarcinoma.Br J Cancer1990https://conductscience.org/library/papers/2390488PubMed
23,670,292High-efficiency transformation of mammalian cells by plasmid DNA.Mol Cell Biol1987https://conductscience.org/library/papers/3670292PubMed
37,539,918Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.Proc Natl Acad Sci U S A1995https://conductscience.org/library/papers/7539918PubMed
48,943,284Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit.J Biol Chem1996https://conductscience.org/library/papers/8943284PubMed
58,995,446The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44MAPK cascade.J Biol Chem1997https://conductscience.org/library/papers/8995446PubMed
69,000,051Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.Genes Dev1997https://conductscience.org/library/papers/9000051PubMed
79,113,979A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development.Proc Natl Acad Sci U S A1997https://conductscience.org/library/papers/9113979PubMed
89,278,421Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes.J Biol Chem1997https://conductscience.org/library/papers/9278421PubMed
99,393,757V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression.Cancer Res1997https://conductscience.org/library/papers/9393757PubMed
109,653,127Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway.Proc Natl Acad Sci U S A1998https://conductscience.org/library/papers/9653127PubMed

1 to 10 of 49

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Cited by627

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1,153 citations.

PMIDTitleJournalYearIn PapersSource
42,872,022Divergent Hypoxia-Inducible Factor 2‑Alpha Signaling in Alcoholic Liver Disease and Metabolic Dysfunction-Associated Steatotic Liver Disease.ACS Pharmacol Transl Sci2026https://conductscience.org/library/papers/42872022PubMed
42,792,843The Molecular Basis and Biomarker Potential of the HIF-1α-VEGF-GLUT1 Hypoxia Axis in Laryngeal Squamous Cell Carcinoma.Biomedicines2026https://conductscience.org/library/papers/42792843PubMed
42,754,649PGC1α-mediated upregulation of PHD2 represses HIF-signaling, limiting prostate cancer progression.Cell Death Differ2026https://conductscience.org/library/papers/42754649PubMed
42,748,913Allosteric modulation of YTHDFs by ellagic acid suppresses triple-negative breast cancer via non-canonical activation of the HIF-1α pathway.Cell Rep Med2026https://conductscience.org/library/papers/42748913PubMed
42,661,733Kuanxiong aerosol protects against coronary microvascular dysfunction through improving angiogenesis via HIF-1α-ITGAX axis.Front Pharmacol2026https://conductscience.org/library/papers/42661733PubMed
42,653,703Dangguibuxue Decoction Attenuated AA I-Induced Renal Fibrosis: Integrating Network Pharmacology and Experimental Validation.Pharmaceuticals (Basel)2026https://conductscience.org/library/papers/42653703PubMed
42,603,195Diagnostic accuracy and smoking-driven modulation of salivary MMP-8, MMP-9, and HIF-1α in stage III grade B/C periodontitis: a cross-sectional study.Clin Oral Investig2026https://conductscience.org/library/papers/42603195PubMed
42,570,141Correspondence: Beyond phenotypic observations: Elucidating the molecular drivers of hypoxia-reoxygenation-induced aggressiveness in breast cancer.Mol Biol Rep2026https://conductscience.org/library/papers/42570141PubMed
42,348,440PHD1-dependent hydroxylation of RepoMan (CDCA2) on P604 modulates the control of mitotic progression.Elife2026https://conductscience.org/library/papers/42348440PubMed
42,343,419Astrocytic VPS35 coordinates iron homeostasis with HIF1α-VEGFa signaling to prevent astrocytic ferroptosis and to promote neocortical angiogenesis.Cell Biosci2026https://conductscience.org/library/papers/42343419PubMed

1 to 10 of 627

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Genes6

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CBLL2158,506PubTator's text mininghttps://conductscience.org/library/genes/158506NCBI Gene
EGLN154,583PubTator's text mininghttps://conductscience.org/library/genes/54583NCBI Gene
EGLN2112,398PubTator's text mininghttps://conductscience.org/library/genes/112398NCBI Gene
EGLN3112,399PubTator's text mininghttps://conductscience.org/library/genes/112399NCBI Gene
HIF1A3,091PubTator's text mininghttps://conductscience.org/library/genes/3091NCBI Gene
VHL7,428PubTator's text mininghttps://conductscience.org/library/genes/7428NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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