Paper · 17529967

Genome-wide association study identifies novel breast cancer susceptibility loci.

Easton DF and 104 others. Nature, 2007. Cited by 1,771 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Genome-wide association study identifies novel breast cancer susceptibility loci. Papers, record 17529967. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/17529967

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Genome-wide association study identifies novel breast cancer susceptibility loci.; PubMed
Journal: Nature; PubMed
Year: 2007; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/17529967/; PubMed
DOI: https://doi.org/10.1038/nature05887; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2714974/; PubMed
The journal: https://conductscience.org/library/journal-index/0410462; PubMed
Citations, by iCite: 1,771; iCite
Relative citation ratio, by iCite: 37.1; iCite
Revised in PubMed: 2025-05-29; PubMed

Authors105

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Easton DF	Douglas F
2	Pooley KA	Karen A
3	Dunning AM	Alison M
4	Pharoah PD	Paul D P
5	Thompson D	Deborah
6	Ballinger DG	Dennis G
7	Struewing JP	Jeffery P
8	Morrison J	Jonathan
9	Field H	Helen
10	Luben R	Robert

1 to 10 of 105Source PubMed

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Topics21

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Breast Neoplasms	Major topic
Genetic Predisposition to Disease	Major topic
Genome, Human	Major topic
Alleles
Apoptosis Regulatory Proteins
Asia, Southeastern
Australia
Case-Control Studies
Europe
Female
Genotype
High Mobility Group Proteins
Humans
MAP Kinase Kinase Kinase 1
Microfilament Proteins
North America
Odds Ratio
Polymorphism, Single Nucleotide
Receptor, Fibroblast Growth Factor, Type 2
Receptors, Progesterone
Trans-Activators

Source PubMed

Grants4

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
2004NOV49	Breast Cancer Now	United Kingdom		PubMed	PubMed
A3353	Cancer Research UK	United Kingdom		PubMed	PubMed
BREAST CANCER NOW RESEARCH CENTRE	Breast Cancer Now	United Kingdom		PubMed	PubMed
			Z01SC010083	NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References39

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	11,959,976	Comprehensive human genome amplification using multiple displacement amplification.	Proc Natl Acad Sci U S A	2002	https://conductscience.org/library/papers/11959976	PubMed
2	11,967,536	Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations.	Nat Genet	2002	https://conductscience.org/library/papers/11967536	PubMed
3	11,984,562	Polygenic susceptibility to breast cancer and implications for prevention.	Nat Genet	2002	https://conductscience.org/library/papers/11984562	PubMed
4	12,677,558	Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies.	Am J Hum Genet	2003	https://conductscience.org/library/papers/12677558	PubMed
5	14,557,987	Polygenic inheritance of breast cancer: Implications for design of association studies.	Genet Epidemiol	2003	https://conductscience.org/library/papers/14557987	PubMed
6	15,122,511	CHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies.	Am J Hum Genet	2004	https://conductscience.org/library/papers/15122511	PubMed
7	15,381,934	The BOADICEA model of genetic susceptibility to breast and ovarian cancer.	Br J Cancer	2004	https://conductscience.org/library/papers/15381934	PubMed
8	11,890,312	Two-stage designs for gene-disease association studies.	Biometrics	2002	https://conductscience.org/library/papers/11890312	PubMed
9	11,791,212	Score tests for association between traits and haplotypes when linkage phase is ambiguous.	Am J Hum Genet	2002	https://conductscience.org/library/papers/11791212	PubMed
10	11,752,248	The Ensembl genome database project.	Nucleic Acids Res	2002	https://conductscience.org/library/papers/11752248	PubMed

1 to 10 of 39

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Cited by1,126

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1,771 citations.

PMID	Title	Journal	Year	In Papers	Source
42,679,042	Genetic architectures of brain-related traits are shaped by strong selective constraints.	Proc Natl Acad Sci U S A	2026	https://conductscience.org/library/papers/42679042	PubMed
42,363,452	Unraveling the intricate molecular mechanisms of sex hormones' roles in breast cancer pathogenesis: A review.	Medicine (Baltimore)	2026	https://conductscience.org/library/papers/42363452	PubMed
42,222,333	TNNT3 as a candidate node in breast cancer mechanobiology: current evidence, mechanistic models, and key knowledge gaps.	Front Cell Dev Biol	2026	https://conductscience.org/library/papers/42222333	PubMed
42,062,290	Nuclear genetic modulation of tissue-specific mitochondrial RNA processing contributes to common disease risk.	Nat Commun	2026	https://conductscience.org/library/papers/42062290	PubMed
41,983,230	MMTV Virus Detection, Survival Analysis, and Prognostic Relevance of Six Tumor Genes in Patients With Breast Cancer.	Int J Breast Cancer	2026	https://conductscience.org/library/papers/41983230	PubMed
41,972,694	MAP3K1: A Multifunctional Kinase at the Crossroads of Cancer Progression and Tumor Suppression.	Cells	2026	https://conductscience.org/library/papers/41972694	PubMed
41,929,205	Genetic architectures of brain-related traits are shaped by strong selective constraints.	bioRxiv	2026	https://conductscience.org/library/papers/41929205	PubMed
41,849,381	A transcription regulator atlas identifies TOX3 as an Atoh1 coactivator in cerebellar development and tumorigenesis.	Proc Natl Acad Sci U S A	2026	https://conductscience.org/library/papers/41849381	PubMed
41,318,657	RAD51B-EZH2 axis as a potential therapeutic target for TNBC through cell fate conversion.	Cell Death Dis	2025	https://conductscience.org/library/papers/41318657	PubMed
41,146,041	A systematic review of prediction models for risk of breast cancer.	BMC Cancer	2025	https://conductscience.org/library/papers/41146041	PubMed

1 to 10 of 1,126

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Genes20

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
ATM	472	PubTator's text mining	https://conductscience.org/library/genes/472	NCBI Gene
BRCA1	672	PubTator's text mining	https://conductscience.org/library/genes/672	NCBI Gene
BRCA2	675	PubTator's text mining	https://conductscience.org/library/genes/675	NCBI Gene
BRIP1	83,990	PubTator's text mining	https://conductscience.org/library/genes/83990	NCBI Gene
CASC16	643,714	PubTator's text mining	https://conductscience.org/library/genes/643714	NCBI Gene
CASP8	841	PubTator's text mining	https://conductscience.org/library/genes/841	NCBI Gene
CHEK2	11,200	PubTator's text mining	https://conductscience.org/library/genes/11200	NCBI Gene
EREG	2,069	PubTator's text mining	https://conductscience.org/library/genes/2069	NCBI Gene
FGFR2	2,263	PubTator's text mining	https://conductscience.org/library/genes/2263	NCBI Gene
H19	283,120	PubTator's text mining	https://conductscience.org/library/genes/283120	NCBI Gene

1 to 10 of 20

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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