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Paper · 19903845

Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase.

Pang H and 11 others. Cancer Res, 2009. Cited by 74 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase. Papers, record 19903845. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/19903845

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase.
PubMed
Journal
Cancer Res
PubMed
Year
2009
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
74
iCite
Relative citation ratio, by iCite
1.35
iCite
Revised in PubMed
2025-05-29
PubMed

Authors12

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Pang HHuan
2Flinn RRory
3Patsialou AAntonia
4Wyckoff JJeffrey
5Roussos ETEvanthia T
6Wu HHaiyan
7Pozzuto MMaria
8Goswami SSumanta
9Condeelis JSJohn S
10Bresnick ARAnne R

1 to 10 of 12Source PubMed

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Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Breast NeoplasmsMajor topic
Cell MovementMajor topic
MutationMajor topic
Phosphatidylinositol 3-KinasesMajor topic
Animals
Catalytic Domain
Cattle
Cell Line, Tumor
Class I Phosphatidylinositol 3-Kinases
Female
Humans
Lung Neoplasms
Mice
Protein Structure, Secondary
Protein Subunits

Source PubMed

Grants7

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
P01 CA100324NCI NIH HHSUnited StatesP01CA100324PubMed and NIHNIH RePORTER
R01 GM055692NIGMS NIH HHSUnited StatesR01GM055692PubMed and NIHNIH RePORTER
R01 CA113395NCI NIH HHSUnited StatesR01CA113395PubMed and NIHNIH RePORTER
GM55692NIGMS NIH HHSUnited StatesR01GM055692PubMed and NIHNIH RePORTER
CA113395NCI NIH HHSUnited StatesR01CA113395PubMed and NIHNIH RePORTER
P01 CA 100324NCI NIH HHSUnited StatesP01CA100324PubMed and NIHNIH RePORTER
P30 CA013330NCI NIH HHSUnited StatesP30CA013330PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References38

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
115,930,273Functional analysis of PIK3CA gene mutations in human colorectal cancer.Cancer Res2005https://conductscience.org/library/papers/15930273PubMed
218,084,252PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parameters.Mod Pathol2008https://conductscience.org/library/papers/18084252PubMed
317,888,630Interactions of Ras proteins with the plasma membrane and their roles in signaling.Cell Signal2008https://conductscience.org/library/papers/17888630PubMed
419,573,809AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.Cancer Cell2009https://conductscience.org/library/papers/19573809PubMed
511,036,626Rho GTPases and cell migration: measurement of macrophage chemotaxis.Methods Enzymol2000https://conductscience.org/library/papers/11036626PubMed
617,452,630Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.Proc Natl Acad Sci U S A2007https://conductscience.org/library/papers/17452630PubMed
716,926,057Regulation of the actin cytoskeleton in cancer cell migration and invasion.Biochim Biophys Acta2007https://conductscience.org/library/papers/16926057PubMed
815,647,370Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.Proc Natl Acad Sci U S A2005https://conductscience.org/library/papers/15647370PubMed
918,224,685Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers.Int J Cancer2008https://conductscience.org/library/papers/18224685PubMed
109,276,291Analyzing chemotaxis using the Dunn direct-viewing chamber.Methods Mol Biol1997https://conductscience.org/library/papers/9276291PubMed

1 to 10 of 38

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Cited by59

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 74 citations.

PMIDTitleJournalYearIn PapersSource
40,817,602Gene-specific ctDNA dynamics predict tumour burden and survival outcomes in ESCC: A prospective cohort study.Clin Transl Med2025https://conductscience.org/library/papers/40817602PubMed
40,641,158Prevalence of HPV Infection Among Chinese Males With HPV-Related Diseases: A Systematic Review and Meta-Analysis.J Med Virol2025https://conductscience.org/library/papers/40641158PubMed
39,810,024Decoding the functional impact of the cancer genome through protein-protein interactions.Nat Rev Cancer2025https://conductscience.org/library/papers/39810024PubMed
39,369,580The PIK3CA gene and its pivotal role in tumor tropism of triple-negative breast cancer.Transl Oncol2024https://conductscience.org/library/papers/39369580PubMed
38,466,449PIK3CA mutation-driven immune signature as a prognostic marker for evaluating the tumor immune microenvironment and therapeutic response in breast cancer.J Cancer Res Clin Oncol2024https://conductscience.org/library/papers/38466449PubMed
37,047,566PI4P-Containing Vesicles from Golgi Contribute to Mitochondrial Division by Coordinating with Polymerized Actin.Int J Mol Sci2023https://conductscience.org/library/papers/37047566PubMed
36,069,825A New View of Activating Mutations in Cancer.Cancer Res2022https://conductscience.org/library/papers/36069825PubMed
35,418,124Nuclear translocation of p85β promotes tumorigenesis of PIK3CA helical domain mutant cancer.Nat Commun2022https://conductscience.org/library/papers/35418124PubMed
35,050,709
Apolipoprotein B mRNA-Editing Catalytic Polypeptide-Like-Induced Protein Changes in Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer Throughout Disease Progression.
JCO Precis Oncol2022https://conductscience.org/library/papers/35050709PubMed
34,990,021PIP3 abundance overcomes PI3K signaling selectivity in invadopodia.FEBS Lett2022https://conductscience.org/library/papers/34990021PubMed

1 to 10 of 59

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Genes17

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
AKT1207PubTator's text mininghttps://conductscience.org/library/genes/207NCBI Gene
BRAF673PubTator's text mininghttps://conductscience.org/library/genes/673NCBI Gene
EGF1,950PubTator's text mininghttps://conductscience.org/library/genes/1950NCBI Gene
ERVK-15100,616,443PubTator's text mininghttps://conductscience.org/library/genes/100616443NCBI Gene
KRAS3,845PubTator's text mininghttps://conductscience.org/library/genes/3845NCBI Gene
MAPK15,594PubTator's text mininghttps://conductscience.org/library/genes/5594NCBI Gene
MYC4,609PubTator's text mininghttps://conductscience.org/library/genes/4609NCBI Gene
PDK15,163PubTator's text mininghttps://conductscience.org/library/genes/5163NCBI Gene
PIK3CA5,290PubTator's text mininghttps://conductscience.org/library/genes/5290NCBI Gene
PIK3CB5,291PubTator's text mininghttps://conductscience.org/library/genes/5291NCBI Gene

1 to 10 of 17

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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