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Paper · 23398153

Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism.

Hu MC and 3 others. Annu Rev Physiol, 2013. Cited by 468 papers, by iCite.

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ConductScience Library. Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism. Papers, record 23398153. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/23398153

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism.
PubMed
Journal
Annu Rev Physiol
PubMed
Year
2013
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
PubMed
Citations, by iCite
468
iCite
Relative citation ratio, by iCite
15.6
iCite
Revised in PubMed
2024-03-18
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Hu MCMing Chang
2Shiizaki KKazuhiro
3Kuro-o MMakoto
4Moe OWOrson W

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Endocrine SystemMajor topic
Fibroblast Growth FactorsMajor topic
GlucuronidaseMajor topic
MineralsMajor topic
Animals
Bone and Bones
Fibroblast Growth Factor-23
Homeostasis
Humans
Intestines
Kidney
Klotho Proteins

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 DK091392NIDDK NIH HHSUnited StatesR01DK091392PubMed and NIHNIH RePORTER
R01 DK092461NIDDK NIH HHSUnited StatesR01DK092461PubMed and NIHNIH RePORTER

Trials1

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's record
NCT02830464New Biomarkers in Heart- and Renal FailureBackground

Source ClinicalTrials.gov

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References178

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
120,844,473Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease.Kidney Int2010https://conductscience.org/library/papers/20844473PubMed
220,685,823PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop.Am J Physiol Renal Physiol2010https://conductscience.org/library/papers/20685823PubMed
321,604,189Human nephron number: implications for health and disease.Pediatr Nephrol2011https://conductscience.org/library/papers/21604189PubMed
412,854,832Serum FGF23 levels in normal and disordered phosphorus homeostasis.J Bone Miner Res2003https://conductscience.org/library/papers/12854832PubMed
520,150,940Does the downregulation of the FGF23 signaling pathway in hyperplastic parathyroid glands contribute to refractory secondary hyperparathyroidism in CKD patients?Kidney Int2010https://conductscience.org/library/papers/20150940PubMed
69,528,951Molecular cloning and hormonal regulation of PiT-1, a sodium-dependent phosphate cotransporter from rat parathyroid glands.Endocrinology1998https://conductscience.org/library/papers/9528951PubMed
710,809,780Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4.J Biol Chem2000https://conductscience.org/library/papers/10809780PubMed
817,911,404Fibroblast growth factor-23 regulates parathyroid hormone and 1alpha-hydroxylase expression in cultured bovine parathyroid cells.J Endocrinol2007https://conductscience.org/library/papers/17911404PubMed
920,016,468Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease.Kidney Int2010https://conductscience.org/library/papers/20016468PubMed
1022,457,086Serum levels of soluble secreted α-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis.Clin Exp Nephrol2012https://conductscience.org/library/papers/22457086PubMed

1 to 10 of 178

See all 178 references

Cited by326

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 468 citations.

PMIDTitleJournalYearIn PapersSource
42,964,217Klotho Gene Single-Nucleotide Polymorphism and Proteinuria in a General Population.J Clin Med Res2026https://conductscience.org/library/papers/42964217PubMed
42,853,715Clinical Significance of Klotho, Fibroblast Growth Factor 23, and Their Ratio for Acute Kidney Injury in Sepsis Patients.Med Princ Pract2026https://conductscience.org/library/papers/42853715PubMed
42,666,118SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency.Adv Sci (Weinh)2026https://conductscience.org/library/papers/42666118PubMed
42,633,326Advances in FGF/FGFR Signaling: Implications for Disease and Therapy.MedComm (2020)2026https://conductscience.org/library/papers/42633326PubMed
42,622,967Soluble alpha-klotho as an adjunct biomarker of disease activity in acromegaly: Added value beyond GH and IGF-1.Pituitary2026https://conductscience.org/library/papers/42622967PubMed
42,279,202Association Between Serum α-Klotho Levels and Habitual Physical Activity in Hemodialysis Patients: A Pilot Clinical Study.J Clin Med2026https://conductscience.org/library/papers/42279202PubMed
42,218,196Conserved mRNA expression patterns of the Klotho family in canine mammary tumors and human breast cancer.Sci Rep2026https://conductscience.org/library/papers/42218196PubMed
42,067,671Effects of acute, subacute, and chronic exercise on plasma s-Klotho levels: a systematic review and meta-analysis.J Physiol Biochem2026https://conductscience.org/library/papers/42067671PubMed
41,983,942Neuroprotective roles of klotho: Molecular pathways and therapeutic implications for cognitive health in neurological and psychiatric diseases.Exp Physiol2026https://conductscience.org/library/papers/41983942PubMed
41,789,112Decoding lung-kidney interactions in sepsis: an integrated view of molecular mechanisms, pathophysiology, and therapeutic interventions.Front Immunol2026https://conductscience.org/library/papers/41789112PubMed

1 to 10 of 326

See all 326 cited by

Genes27

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
AGT183PubTator's text mininghttps://conductscience.org/library/genes/183NCBI Gene
APOE348PubTator's text mininghttps://conductscience.org/library/genes/348NCBI Gene
CYP27B11,594PubTator's text mininghttps://conductscience.org/library/genes/1594NCBI Gene
DMP11,758PubTator's text mininghttps://conductscience.org/library/genes/1758NCBI Gene
EPO2,056PubTator's text mininghttps://conductscience.org/library/genes/2056NCBI Gene
FGF12,246PubTator's text mininghttps://conductscience.org/library/genes/2246NCBI Gene
FGF112,256PubTator's text mininghttps://conductscience.org/library/genes/2256NCBI Gene
FGF199,965PubTator's text mininghttps://conductscience.org/library/genes/9965NCBI Gene
FGF22,247PubTator's text mininghttps://conductscience.org/library/genes/2247NCBI Gene
FGF2126,291PubTator's text mininghttps://conductscience.org/library/genes/26291NCBI Gene

1 to 10 of 27

See all 27 genes

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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