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Paper · 26059619

Composition, structure and function of the Helicobacter pylori cag pathogenicity island encoded type IV secretion system.

Backert S and 2 others. Future Microbiol, 2015. Cited by 163 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Composition, structure and function of the Helicobacter pylori cag pathogenicity island encoded type IV secretion system. Papers, record 26059619. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/26059619

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Composition, structure and function of the Helicobacter pylori cag pathogenicity island encoded type IV secretion system.
PubMed
Journal
Future Microbiol
PubMed
Year
2015
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
PubMed
Citations, by iCite
163
iCite
Relative citation ratio, by iCite
5.88
iCite
Revised in PubMed
2022-03-31
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Backert SSteffen
2Tegtmeyer NNicole
3Fischer WWolfgang

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Genomic IslandsMajor topic
Helicobacter pyloriMajor topic
Type IV Secretion SystemsMajor topic
Antigens, Bacterial
Bacterial Adhesion
Bacterial Proteins
Epithelial Cells
Humans
Models, Biological
Protein Conformation
Protein Multimerization
Protein Transport
Virulence Factors

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 AI108713NIAID NIH HHSUnited StatesR01AI108713PubMed and NIHNIH RePORTER
1R011AM087NIADDK NIH HHSUnited StatesPubMedPubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References65

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
122,908,298Structural insights into Helicobacter pylori oncoprotein CagA interaction with β1 integrin.Proc Natl Acad Sci U S A2012https://conductscience.org/library/papers/22908298PubMed
224,891,108Genes required for assembly of pili associated with the Helicobacter pylori cag type IV secretion system.Infect Immun2014https://conductscience.org/library/papers/24891108PubMed
312,780,777Structural definition on the surface of Helicobacter pylori type IV secretion apparatus.Cell Microbiol2003https://conductscience.org/library/papers/12780777PubMed
416,939,533Pathogenicity islands: a molecular toolbox for bacterial virulence.Cell Microbiol2006https://conductscience.org/library/papers/16939533PubMed
524,097,901Echoes of a distant past: The cag pathogenicity island of Helicobacter pylori.Cold Spring Harb Perspect Med2013https://conductscience.org/library/papers/24097901PubMed
622,287,591Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin-integrin linked kinase signalling complex.Gut2012https://conductscience.org/library/papers/22287591PubMed
719,966,800Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates.Nat Struct Mol Biol2010https://conductscience.org/library/papers/19966800PubMed
819,946,264Structure of the outer membrane complex of a type IV secretion system.Nature2009https://conductscience.org/library/papers/19946264PubMed
92,307,514Characterization of and human serologic response to proteins in Helicobacter pylori broth culture supernatants with vacuolizing cytotoxin activity.Infect Immun1990https://conductscience.org/library/papers/2307514PubMed
1024,670,658Structure of a type IV secretion system.Nature2014https://conductscience.org/library/papers/24670658PubMed

1 to 10 of 65

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Cited by114

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 163 citations.

PMIDTitleJournalYearIn PapersSource
42,963,802Evolution and function of genetic polymorphisms in the Helicobacter pylori type IV secretion pilus protein CagL in gastric carcinogenesis.Cell Commun Signal2026https://conductscience.org/library/papers/42963802PubMed
42,786,516Serial serum interleukin-8 trajectories are associated with progression from Helicobacter pylori-associated precancerous lesions to gastric cancer: a prospective longitudinal cohort study.Gut Pathog2026https://conductscience.org/library/papers/42786516PubMed
42,772,936Beyond PD-L1/PD-1: expression of PVR/TIGIT and TNFRSF14/BTLA axes in response to Helicobacter pylori and in gastric cancer lesions.Immunohorizons2026https://conductscience.org/library/papers/42772936PubMed
42,642,391Deciphering the initiation pathway of CagT4SS assembly by in vitro reconstitution of subcomplexes.Nat Commun2026https://conductscience.org/library/papers/42642391PubMed
42,531,194Mechanistic evaluation of NSC 57774 as a SHP2 inhibitor in gastric cancer: Multi-pathway signaling modulation in vitro.PLoS One2026https://conductscience.org/library/papers/42531194PubMed
42,336,815The "Hit-and-Run" legacy: epigenetic locking and the survival switch in H. pylori-associated gastric cancer.Cell Death Discov2026https://conductscience.org/library/papers/42336815PubMed
42,035,012Computational design of a multi-epitope vaccine against Helicobacter pylori targeting CagA, FliD, urease, and OipA with cholera toxin B subunit (CTB) adjuvant.BMC Microbiol2026https://conductscience.org/library/papers/42035012PubMed
41,838,338The role of gut microbiota in the development, diagnosis, and treatment of gastric cancer.Folia Microbiol (Praha)2026https://conductscience.org/library/papers/41838338PubMed
41,581,762Reprogramming host histone modifications by bacterial pathogens.Mol Cells2026https://conductscience.org/library/papers/41581762PubMed
41,347,241Microbial oncogenesis within the gastric niche: how the gastric microbiota influences H. pylori-induced disease progression.Front Microbiol2025https://conductscience.org/library/papers/41347241PubMed

1 to 10 of 114

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Genes35

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ABL125PubTator's text mininghttps://conductscience.org/library/genes/25NCBI Gene
ADAM176,868PubTator's text mininghttps://conductscience.org/library/genes/6868NCBI Gene
CDC42998PubTator's text mininghttps://conductscience.org/library/genes/998NCBI Gene
CDH1999PubTator's text mininghttps://conductscience.org/library/genes/999NCBI Gene
CHUK1,147PubTator's text mininghttps://conductscience.org/library/genes/1147NCBI Gene
CRK1,398PubTator's text mininghttps://conductscience.org/library/genes/1398NCBI Gene
CTNNB11,499PubTator's text mininghttps://conductscience.org/library/genes/1499NCBI Gene
CTTN2,017PubTator's text mininghttps://conductscience.org/library/genes/2017NCBI Gene
CXCL83,576PubTator's text mininghttps://conductscience.org/library/genes/3576NCBI Gene
DDX53168,400PubTator's text mininghttps://conductscience.org/library/genes/168400NCBI Gene

1 to 10 of 35

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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