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Paper · 28972001

Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis.

Zhang H and 17 others. Circulation, 2017. Cited by 219 papers, by iCite.

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ConductScience Library. Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis. Papers, record 28972001. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/28972001

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis.
PubMed
Journal
Circulation
PubMed
Year
2017
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
219
iCite
Relative citation ratio, by iCite
7.62
iCite
Revised in PubMed
2025-05-30
PubMed

Authors18

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Zhang HHui
2Wang DDaren
3Li MMin
4Plecitá-Hlavatá LLydie
5D'Alessandro AAngelo
6Tauber JJan
7Riddle SSuzette
8Kumar SSushil
9Flockton AAmanda
10McKeon BAB Alexandre

1 to 10 of 18Source PubMed

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Topics22

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Heterogeneous-Nuclear RibonucleoproteinsMajor topic
Hypertension, PulmonaryMajor topic
MicroRNAsMajor topic
Polypyrimidine Tract-Binding ProteinMajor topic
Pyruvate KinaseMajor topic
Alternative Splicing
Animals
Antagomirs
Cattle
Cell Proliferation
Endothelium, Vascular
Fibroblasts
Glycolysis
Histone Deacetylase Inhibitors
Humans
Interleukin-1beta
Macrophages
Mice
Mice, Inbred C57BL
Naphthoquinones
Protein Isoforms
RNA Interference

Source PubMed

Grants7

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
P50 CA058187NCI NIH HHSUnited StatesP50CA058187PubMedNIH RePORTER
P30 DK048520NIDDK NIH HHSUnited StatesP30DK048520PubMed and NIHNIH RePORTER
T32 HL007171NHLBI NIH HHSUnited StatesT32HL007171PubMed and NIHNIH RePORTER
FS/13/19/29931British Heart FoundationUnited KingdomPubMedPubMed
RG/13/4/30107British Heart FoundationUnited KingdomPubMedPubMed
P01 HL014985NHLBI NIH HHSUnited StatesP01HL014985PubMed and NIHNIH RePORTER
R01 HL114887NHLBI NIH HHSUnited StatesR01HL114887PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Comment in29,255,124Pyruvate Kinase and Warburg Metabolism in Pulmonary Arterial Hypertension: Uncoupled Glycolysis and the Cancer-Like Phenotype of Pulmonary Arterial Hypertension.https://conductscience.org/library/papers/29255124

Source PubMed

References49

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
127,562,971
Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1.
Circulation2016https://conductscience.org/library/papers/27562971PubMed
226,277,545Pyruvate kinase: Function, regulation and role in cancer.Semin Cell Dev Biol2015https://conductscience.org/library/papers/26277545PubMed
315,739,122Antiproliferative effect of sildenafil on human pulmonary artery smooth muscle cells.Basic Res Cardiol2005https://conductscience.org/library/papers/15739122PubMed
523,900,048
Heterogeneity in lung (18)FDG uptake in pulmonary arterial hypertension: potential of dynamic (18)FDG positron emission tomography with kinetic analysis as a bridging biomarker for pulmonary vascular remodeling targeted treatments.
Circulation2013https://conductscience.org/library/papers/23900048PubMed
627,856,534PKM2, cancer metabolism, and the road ahead.EMBO Rep2016https://conductscience.org/library/papers/27856534PubMed
722,792,411Regulation of Aerobic Glycolysis by microRNAs in Cancer.Mol Cell Pharmacol2011https://conductscience.org/library/papers/22792411PubMed
822,922,757Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.Nat Chem Biol2012https://conductscience.org/library/papers/22922757PubMed
924,382,387New and emerging HDAC inhibitors for cancer treatment.J Clin Invest2014https://conductscience.org/library/papers/24382387PubMed
1023,617,881Metabolic dysfunction in pulmonary hypertension: the expanding relevance of the Warburg effect.Eur J Clin Invest2013https://conductscience.org/library/papers/23617881PubMed
1126,699,943Constitutive Reprogramming of Fibroblast Mitochondrial Metabolism in Pulmonary Hypertension.Am J Respir Cell Mol Biol2016https://conductscience.org/library/papers/26699943PubMed

1 to 10 of 49

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Cited by161

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 219 citations.

PMIDTitleJournalYearIn PapersSource
42,893,628Phasic metabolic remodeling coordinates cardiac myofibroblast differentiation and function.Redox Biol2026https://conductscience.org/library/papers/42893628PubMed
42,733,743Heterogeneous nuclear ribonucleoprotein A1 as a candidate associated with pulmonary vascular remodeling in pulmonary arterial hypertension.J Mol Cell Cardiol Plus2026https://conductscience.org/library/papers/42733743PubMed
42,681,428High-Throughput Metabolomics in Transfusion Medicine.Methods Mol Biol2026https://conductscience.org/library/papers/42681428PubMed
42,559,126Recent advances in targeting cyanine dyes: hierarchical targeting mechanisms and theranostic integration for multi-disease precision therapy.Theranostics2026https://conductscience.org/library/papers/42559126PubMed
42,171,611Hemodynamic and metabolomic responses to infusion of GLP-1 agonist exenatide in pulmonary arterial hypertension.JCI Insight2026https://conductscience.org/library/papers/42171611PubMed
42,148,308PKM2 mediates the glycolytic response to matrix stiffness in lung fibroblasts.Front Cell Dev Biol2026https://conductscience.org/library/papers/42148308PubMed
42,047,020Dynamin 2 Regulates Mitochondrial Mitotic Fission in Pulmonary Hypertension.Circ Res2026https://conductscience.org/library/papers/42047020PubMed
41,881,976Dimeric PKM2 in chondrocytes impairs mitochondrial homeostasis in osteoarthritis.Cell Death Dis2026https://conductscience.org/library/papers/41881976PubMed
41,526,595Circulating microRNAs in pulmonary arterial hypertension: biomarkers for diagnosis, prognostic stratification, and treatment.Geroscience2026https://conductscience.org/library/papers/41526595PubMed
41,393,963A Lifelong Journey in the Field of the Pulmonary Circulation: Perspectives Through the Lens of the Cardiovascular Pulmonary Research Laboratory.Pulm Circ2025https://conductscience.org/library/papers/41393963PubMed

1 to 10 of 161

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Genes16

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
BMPR2659PubTator's text mininghttps://conductscience.org/library/genes/659NCBI Gene
HNRNPA13,178PubTator's text mininghttps://conductscience.org/library/genes/3178NCBI Gene
HNRNPA2B13,181PubTator's text mininghttps://conductscience.org/library/genes/3181NCBI Gene
HNRNPC3,183PubTator's text mininghttps://conductscience.org/library/genes/3183NCBI Gene
IL1B3,553PubTator's text mininghttps://conductscience.org/library/genes/3553NCBI Gene
IL63,569PubTator's text mininghttps://conductscience.org/library/genes/3569NCBI Gene
MPC151,660PubTator's text mininghttps://conductscience.org/library/genes/51660NCBI Gene
MPC225,874PubTator's text mininghttps://conductscience.org/library/genes/25874NCBI Gene
PDK15,163PubTator's text mininghttps://conductscience.org/library/genes/5163NCBI Gene
PDP154,704PubTator's text mininghttps://conductscience.org/library/genes/54704NCBI Gene

1 to 10 of 16

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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