Paper · 29255124

Pyruvate Kinase and Warburg Metabolism in Pulmonary Arterial Hypertension: Uncoupled Glycolysis and the Cancer-Like Phenotype of Pulmonary Arterial Hypertension.

Archer SL. Circulation, 2017. Cited by 73 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Pyruvate Kinase and Warburg Metabolism in Pulmonary Arterial Hypertension: Uncoupled Glycolysis and the Cancer-Like Phenotype of Pulmonary Arterial Hypertension. Papers, record 29255124. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/29255124

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Pyruvate Kinase and Warburg Metabolism in Pulmonary Arterial Hypertension: Uncoupled Glycolysis and the Cancer-Like Phenotype of Pulmonary Arterial Hypertension.; PubMed
Journal: Circulation; PubMed
Year: 2017; PubMed
Publication types: Editorial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Comment; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/29255124/; PubMed
DOI: https://doi.org/10.1161/circulationaha.117.031655; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC5739072/; PubMed
The journal: https://conductscience.org/library/journal-index/0147763; PubMed
Citations, by iCite: 73; iCite
Relative citation ratio, by iCite: 2.63; iCite
Revised in PubMed: 2019-03-04; PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Archer SL	Stephen L

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Hypertension, Pulmonary	Major topic
Neoplasms	Major topic
Endothelial Cells
Glycolysis
Heterogeneous-Nuclear Ribonucleoproteins
Humans
MicroRNAs
Phenotype
Polypyrimidine Tract-Binding Protein
Pyruvate Kinase

Source PubMed

Grants4

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
R01 HL071115	NHLBI NIH HHS	United States	R01HL071115	PubMed and NIH	NIH RePORTER
R01 HL113003	NHLBI NIH HHS	United States	R01HL113003	PubMed and NIH	NIH RePORTER
RC1 HL099462	NHLBI NIH HHS	United States	RC1HL099462	PubMed and NIH	NIH RePORTER
	CIHR	Canada		PubMed	PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections2

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

Kind	PMID	Title	In Papers	Source
Comment on	28,971,999	Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2.	https://conductscience.org/library/papers/28971999	PubMed
Comment on	28,972,001	Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis.	https://conductscience.org/library/papers/28972001	PubMed

References21

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	23,247,844	FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate.	J Mol Med (Berl)	2013	https://conductscience.org/library/papers/23247844	PubMed
2	16,282,179	Acute oxygen-sensing mechanisms.	N Engl J Med	2005	https://conductscience.org/library/papers/16282179	PubMed
3	28,971,999	Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2.	Circulation	2017	https://conductscience.org/library/papers/28971999	PubMed
4	26,224,795	Bromodomain-Containing Protein 4: The Epigenetic Origin of Pulmonary Arterial Hypertension.	Circ Res	2015	https://conductscience.org/library/papers/26224795	PubMed
5	15,996,096	Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.	Biochemistry	2005	https://conductscience.org/library/papers/15996096	PubMed
6	25,458,841	A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth.	Mol Cell	2014	https://conductscience.org/library/papers/25458841	PubMed
7	24,481,450	Control of glioma cell death and differentiation by PKM2-Oct4 interaction.	Cell Death Dis	2014	https://conductscience.org/library/papers/24481450	PubMed
8	21,620,138	Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.	Cell	2011	https://conductscience.org/library/papers/21620138	PubMed
9	25,778,902	Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by lipopolysaccharide in colorectal cancer.	Cell Signal	2015	https://conductscience.org/library/papers/25778902	PubMed
10	24,120,661	Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization.	Mol Cell	2013	https://conductscience.org/library/papers/24120661	PubMed

1 to 10 of 21

See all 21 references

Cited by55

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 73 citations.

PMID	Title	Journal	Year	In Papers	Source
42,929,872	Tirzepatide Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension: Association with the SIRT1/H4K12la/c-Jun Axis.	Cells	2026	https://conductscience.org/library/papers/42929872	PubMed
42,212,385	Sex-dependent differences in mitochondrial protein acetylation in metabolic condition, oxidative stress, vascular dysfunction, hypertension, and cardiovascular disease.	Clin Sci (Lond)	2026	https://conductscience.org/library/papers/42212385	PubMed
41,032,703	Macrophage plasticity and glucose metabolism: the role of immunometabolism in pulmonary arterial hypertension.	Clin Sci (Lond)	2025	https://conductscience.org/library/papers/41032703	PubMed
41,011,644	Can Sirtuin 1 Serve as a Therapeutic Target in Pulmonary Arterial Hypertension? A Comprehensive Review.	Molecules	2025	https://conductscience.org/library/papers/41011644	PubMed
40,796,654	C-type natriuretic peptide attenuates enhanced glycolysis and de novo pyrimidine synthesis in pericytes of patients with pulmonary arterial hypertension.	Commun Biol	2025	https://conductscience.org/library/papers/40796654	PubMed
40,776,975	Metabolic Alterations Associated With Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: The Modulatory Effects and Improvement Mechanisms of Exercise.	Rev Cardiovasc Med	2025	https://conductscience.org/library/papers/40776975	PubMed
40,680,382	c-Myc promotes metabolic reprogramming in pulmonary hypertension via the stimulation of glutaminolysis and the reductive tricarboxylic acid cycle.	Redox Biol	2025	https://conductscience.org/library/papers/40680382	PubMed
40,401,523	Transcriptional signatures of endothelial cells shape immune responses in cardiopulmonary health and disease.	JCI Insight	2025	https://conductscience.org/library/papers/40401523	PubMed
40,277,943	Mitochondrial Dysfunction: A New Hallmark in Hereditable Thoracic Aortic Aneurysm Development.	Cells	2025	https://conductscience.org/library/papers/40277943	PubMed
40,274,312	Tet Methylcytosine Dioxygenase 2 (TET2) Mutation Drives a Global Hypermethylation Signature in Patients With Pulmonary Arterial Hypertension (PAH): Correlation With Altered Gene Expression Relevant to a Common T Cell Phenotype.	Compr Physiol	2025	https://conductscience.org/library/papers/40274312	PubMed

1 to 10 of 55

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Genes17

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
BMPR2	659	PubTator's text mining	https://conductscience.org/library/genes/659	NCBI Gene
BRD4	23,476	PubTator's text mining	https://conductscience.org/library/genes/23476	NCBI Gene
CCND1	595	PubTator's text mining	https://conductscience.org/library/genes/595	NCBI Gene
CTNNB1	1,499	PubTator's text mining	https://conductscience.org/library/genes/1499	NCBI Gene
DNMT1	1,786	PubTator's text mining	https://conductscience.org/library/genes/1786	NCBI Gene
DNMT3B	1,789	PubTator's text mining	https://conductscience.org/library/genes/1789	NCBI Gene
IL1B	3,553	PubTator's text mining	https://conductscience.org/library/genes/3553	NCBI Gene
LDHA	3,939	PubTator's text mining	https://conductscience.org/library/genes/3939	NCBI Gene
MCU	90,550	PubTator's text mining	https://conductscience.org/library/genes/90550	NCBI Gene
MIR204	406,987	PubTator's text mining	https://conductscience.org/library/genes/406987	NCBI Gene

1 to 10 of 17

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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