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Paper · 21620138

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.

Luo W and 8 others. Cell, 2011. Cited by 1,243 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Papers, record 21620138. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/21620138

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.
PubMed
Journal
Cell
PubMed
Year
2011
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
1,243
iCite
Relative citation ratio, by iCite
29.2
iCite
Revised in PubMed
2026-01-28
PubMed

Authors9

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Luo WWeibo
2Hu HHongxia
3Chang RRyan
4Zhong JJun
5Knabel MMatthew
6O'Meally RRobert
7Cole RNRobert N
8Pandey AAkhilesh
9Semenza GLGregg L

Source PubMed

Topics20

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cell HypoxiaMajor topic
DioxygenasesMajor topic
Hypoxia-Inducible Factor 1, alpha SubunitMajor topic
NeoplasmsMajor topic
Pyruvate KinaseMajor topic
Animals
Cell Line, Tumor
Feedback
Gene Knockdown Techniques
Gene Knockout Techniques
HeLa Cells
Humans
Hypoxia-Inducible Factor 1
Hypoxia-Inducible Factor-Proline Dioxygenases
Metabolic Networks and Pathways
Mice
Response Elements
Transcriptional Activation
p300-CBP Transcription Factors
p300-CBP-Associated Factor

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
N01 HV028180NHLBI NIH HHSUnited StatesN01HV028180PubMed and NIHNIH RePORTER
N268201000032CPHS HHSUnited StatesPubMedPubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections2

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn PapersSource
Comment in21,620,132PK-M2 Makes Cells Sweeter on HIF1.https://conductscience.org/library/papers/21620132PubMed
Comment in21,654,817Cancer metabolism: feed it forward.https://conductscience.org/library/papers/21654817PubMed

References28

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
113,130,303Targeting HIF-1 for cancer therapy.Nat Rev Cancer2003https://conductscience.org/library/papers/13130303PubMed
219,920,251Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.Sci Signal2009https://conductscience.org/library/papers/19920251PubMed
318,498,744Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.Mol Cell2008https://conductscience.org/library/papers/18498744PubMed
417,418,790HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells.Cell2007https://conductscience.org/library/papers/17418790PubMed
511,902,584Hypoxia--a key regulatory factor in tumour growth.Nat Rev Cancer2002https://conductscience.org/library/papers/11902584PubMed
612,912,907HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.EMBO J2003https://conductscience.org/library/papers/12912907PubMed
715,996,096Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.Biochemistry2005https://conductscience.org/library/papers/15996096PubMed
811,595,184C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.Cell2001https://conductscience.org/library/papers/11595184PubMed
920,010,808HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.Nature2010https://conductscience.org/library/papers/20010808PubMed
1015,823,097Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene.Biochem J2005https://conductscience.org/library/papers/15823097PubMed

1 to 10 of 28

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Cited by885

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1,243 citations.

PMIDTitleJournalYearIn PapersSource
42,985,372Hexokinases and Glial Tumor Metabolism: A Bridge between Bioenergetics and Translational Oncology.Oncol Res2026https://conductscience.org/library/papers/42985372PubMed
42,934,867Melatonin Mitigates Doxorubicin-Induced Cardiotoxicity by Targeting the USP18/PKM2 Axis Without Compromising Antitumor Efficacy.Adv Sci (Weinh)2026https://conductscience.org/library/papers/42934867PubMed
42,896,440Hypoxia-induced SATB homeobox 2 increases hypoxia-inducible factor-1-dependent tumorigenesis and drives bevacizumab resistance in lung adenocarcinoma.Transl Oncol2026https://conductscience.org/library/papers/42896440PubMed
42,882,502Hypoxia-ROS-HSP Triad Axis in Cancer: Mechanisms, Crosstalk, and Therapeutic Implications.Cells2026https://conductscience.org/library/papers/42882502PubMed
42,851,167Spatiotemporal heterogeneity and dynamic evolution of microglial glucose metabolic reprogramming in Alzheimer's disease.Alzheimers Dement2026https://conductscience.org/library/papers/42851167PubMed
42,780,579Research progress on protein lactylation in female reproductive disease: molecular mechanisms, functions, and therapeutic implications.Front Pharmacol2026https://conductscience.org/library/papers/42780579PubMed
42,762,272Sodium Sulfite as an Oxygen-Depletion-Based Chemical Model of Tumor Hypoxia In Vitro.Appl Biochem Biotechnol2026https://conductscience.org/library/papers/42762272PubMed
42,737,822Biomolecular Condensates Integrate Transcriptional and Epigenetic Responses to Hypoxia.Int J Mol Sci2026https://conductscience.org/library/papers/42737822PubMed
42,726,156HDCA suppresses exosomal lncRNA MSTRG171708 release to inhibit Treg-mediated immunometabolism in hepatocellular carcinoma.Mol Biomed2026https://conductscience.org/library/papers/42726156PubMed
42,694,344My Love Story With HIFs in the Disc: A Journey to the Humboldt Research Award.JOR Spine2026https://conductscience.org/library/papers/42694344PubMed

1 to 10 of 885

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Genes31

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
EGLN3112,399Swiss-Prot's referenceshttps://conductscience.org/library/genes/112399NCBI Gene
PKM5,315Swiss-Prot's referenceshttps://conductscience.org/library/genes/5315NCBI Gene
ADRB2154PubTator's text mininghttps://conductscience.org/library/genes/154NCBI Gene
ARNT405PubTator's text mininghttps://conductscience.org/library/genes/405NCBI Gene
ATF4468PubTator's text mininghttps://conductscience.org/library/genes/468NCBI Gene
COX4I11,327PubTator's text mininghttps://conductscience.org/library/genes/1327NCBI Gene
CUL28,453PubTator's text mininghttps://conductscience.org/library/genes/8453NCBI Gene
EGLN154,583PubTator's text mininghttps://conductscience.org/library/genes/54583NCBI Gene
EGLN2112,398PubTator's text mininghttps://conductscience.org/library/genes/112398NCBI Gene
ELOB6,923PubTator's text mininghttps://conductscience.org/library/genes/6923NCBI Gene

1 to 10 of 31

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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