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Paper · 32606754

Brevilin A, a Natural Sesquiterpene Lactone Inhibited the Growth of Triple-Negative Breast Cancer Cells via Akt/mTOR and STAT3 Signaling Pathways.

Qu Z and 5 others. Onco Targets Ther, 2020. Cited by 23 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Brevilin A, a Natural Sesquiterpene Lactone Inhibited the Growth of Triple-Negative Breast Cancer Cells via Akt/mTOR and STAT3 Signaling Pathways. Papers, record 32606754. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/32606754

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Brevilin A, a Natural Sesquiterpene Lactone Inhibited the Growth of Triple-Negative Breast Cancer Cells via Akt/mTOR and STAT3 Signaling Pathways.
PubMed
Journal
Onco Targets Ther
PubMed
Year
2020
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
23
iCite
Relative citation ratio, by iCite
1.39
iCite
Revised in PubMed
2022-04-15
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Qu ZZhao
2Lin YYushan
3Mok DKDaniel Kam-Wah
4Bian QQingya
5Tai WCWilliam Chi-Shing
6Chen SSibao

Source PubMed

Topics0

NLM's MeSH indexing of the paper, its major topics first.

None in this release.

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References25

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
119,238,148Cell cycle, CDKs and cancer: a changing paradigm.Nat Rev Cancer2009https://conductscience.org/library/papers/19238148PubMed
226,916,116The Enigma of Rapamycin Dosage.Mol Cancer Ther2016https://conductscience.org/library/papers/26916116PubMed
323,071,863Phosphorylated mTOR expression correlates with poor outcome in early-stage triple negative breast carcinomas.Int J Clin Exp Pathol2012https://conductscience.org/library/papers/23071863PubMed
431,500,389Brevilin A, a Sesquiterpene Lactone, Inhibits the Replication of Influenza A Virus In Vitro and In Vivo.Viruses2019https://conductscience.org/library/papers/31500389PubMed
531,178,739Brevilin A Induces Cell Cycle Arrest and Apoptosis in Nasopharyngeal Carcinoma.Front Pharmacol2019https://conductscience.org/library/papers/31178739PubMed
631,781,335Natural Sesquiterpene Lactones Enhance Chemosensitivity of Tumor Cells through Redox Regulation of STAT3 Signaling.Oxid Med Cell Longev2019https://conductscience.org/library/papers/31781335PubMed
730,410,360Brevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells.Onco Targets Ther2018https://conductscience.org/library/papers/30410360PubMed
811,073,801Mechanisms of apoptosis.Am J Pathol2000https://conductscience.org/library/papers/11073801PubMed
923,222,093Updates in the treatment of basal/triple-negative breast cancer.Curr Opin Obstet Gynecol2013https://conductscience.org/library/papers/23222093PubMed
1030,207,593Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.CA Cancer J Clin2018https://conductscience.org/library/papers/30207593PubMed

1 to 10 of 25

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Cited by17

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 23 citations.

PMIDTitleJournalYearIn PapersSource
41,510,721Targeting STAT3 in Breast Cancer Using Innovative Natural and Synthetic Scaffolds to Trigger Apoptosis, Autophagy, and Halt Tumor Progression.Curr Drug Targets2026https://conductscience.org/library/papers/41510721PubMed
40,372,575Natural sesquiterpene lactones in prostate cancer therapy: mechanisms and sources.Med Oncol2025https://conductscience.org/library/papers/40372575PubMed
40,211,707Brevilin A inhibits IL‑17A‑induced inflammation in psoriasis by modulating HSP 70.Mol Med Rep2025https://conductscience.org/library/papers/40211707PubMed
40,001,571Sesquiterpene Lactones as Promising Phytochemicals to Cease Metastatic Propagation of Cancer.Biomolecules2025https://conductscience.org/library/papers/40001571PubMed
39,857,717Sesquiterpene Lactones as Promising Anti-Glioblastoma Drug Candidates Exerting Complex Effects on Glioblastoma Cell Viability and Proneural-Mesenchymal Transition.Biomedicines2025https://conductscience.org/library/papers/39857717PubMed
38,840,248Mechanistic prediction and validation of Brevilin A Therapeutic effects in Lung Cancer.BMC Complement Med Ther2024https://conductscience.org/library/papers/38840248PubMed
38,744,788Brevilin A Inhibits Prostate Cancer Progression by Decreasing PAX5-Activated SOX4.Mol Biotechnol2025https://conductscience.org/library/papers/38744788PubMed
38,699,644Potential therapeutic targets of the JAK2/STAT3 signaling pathway in triple-negative breast cancer.Front Oncol2024https://conductscience.org/library/papers/38699644PubMed
38,067,432In Vitro and In Vivo Anti-Cancer Activity of Lasiokaurin in a Triple-Negative Breast Cancer Model.Molecules2023https://conductscience.org/library/papers/38067432PubMed
37,593,607Brevilin A exerts anti-colorectal cancer effects and potently inhibits STAT3 signaling invitro.Heliyon2023https://conductscience.org/library/papers/37593607PubMed

1 to 10 of 17

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Genes13

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
AKT1207PubTator's text mininghttps://conductscience.org/library/genes/207NCBI Gene
ANXA5308PubTator's text mininghttps://conductscience.org/library/genes/308NCBI Gene
CASP3836PubTator's text mininghttps://conductscience.org/library/genes/836NCBI Gene
CCNB1891PubTator's text mininghttps://conductscience.org/library/genes/891NCBI Gene
CCND1595PubTator's text mininghttps://conductscience.org/library/genes/595NCBI Gene
CCND3896PubTator's text mininghttps://conductscience.org/library/genes/896NCBI Gene
CDK1983PubTator's text mininghttps://conductscience.org/library/genes/983NCBI Gene
CDK61,021PubTator's text mininghttps://conductscience.org/library/genes/1021NCBI Gene
ESR12,099PubTator's text mininghttps://conductscience.org/library/genes/2099NCBI Gene
MTOR2,475PubTator's text mininghttps://conductscience.org/library/genes/2475NCBI Gene

1 to 10 of 13

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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