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Paper · 33097693

Prime editing for functional repair in patient-derived disease models.

Schene IF and 11 others. Nat Commun, 2020. Cited by 188 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Prime editing for functional repair in patient-derived disease models. Papers, record 33097693. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/33097693

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Prime editing for functional repair in patient-derived disease models.
PubMed
Journal
Nat Commun
PubMed
Year
2020
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
188
iCite
Relative citation ratio, by iCite
7.19
iCite
Revised in PubMed
2024-08-03
PubMed

Authors12

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Schene IFImre F
2Joore IPIndi P
3Oka RRurikahttps://orcid.org/0000-0003-4107-7250
4Mokry MMichalhttps://orcid.org/0000-0002-5298-4852
5van Vugt AHMAnke H M
6van Boxtel RRubenhttps://orcid.org/0000-0003-1285-2836
7van der Doef HPJHubert P J
8van der Laan LJWLuc J Whttps://orcid.org/0000-0002-0651-5334
9Verstegen MMAMonique M A
10van Hasselt PMPeter M

1 to 10 of 12Source PubMed

See all 12 authors

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Gene EditingMajor topic
OrganoidsMajor topic
beta CateninMajor topic
CRISPR-Cas Systems
Cell Line
Cell Proliferation
Copper-Transporting ATPases
Deoxyribonuclease I
Diacylglycerol O-Acyltransferase
HEK293 Cells
Hepatolenticular Degeneration
High-Throughput Nucleotide Sequencing
Humans
Mutation
Recombinational DNA Repair
Stem Cells
Targeted Gene Repair

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References26

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
123,354,049In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.Nature2013https://conductscience.org/library/papers/23354049PubMed
227,315,476Modeling Development and Disease with Organoids.Cell2016https://conductscience.org/library/papers/27315476PubMed
324,463,181Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases.Bioinformatics2014https://conductscience.org/library/papers/24463181PubMed
429,813,047Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction.Nat Biotechnol2018https://conductscience.org/library/papers/29813047PubMed
521,478,889A framework for variation discovery and genotyping using next-generation DNA sequencing data.Nat Genet2011https://conductscience.org/library/papers/21478889PubMed
631,634,902Search-and-replace genome editing without double-strand breaks or donor DNA.Nature2019https://conductscience.org/library/papers/31634902PubMed
730,323,312Base editing: precision chemistry on the genome and transcriptome of living cells.Nat Rev Genet2018https://conductscience.org/library/papers/30323312PubMed
827,698,416Tissue-specific mutation accumulation in human adult stem cells during life.Nature2016https://conductscience.org/library/papers/27698416PubMed
919,329,995Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.Nature2009https://conductscience.org/library/papers/19329995PubMed
1020,080,505Fast and accurate long-read alignment with Burrows-Wheeler transform.Bioinformatics2010https://conductscience.org/library/papers/20080505PubMed

1 to 10 of 26

See all 26 references

Cited by143

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 188 citations.

PMIDTitleJournalYearIn PapersSource
42,891,351Strategies and mechanisms of precision genome engineering: From gene editing to genome writing.IMetaOmics2026https://conductscience.org/library/papers/42891351PubMed
42,840,083Genome edited sheep generated by zygote electroporation of prime editor ribonucleoproteins.Front Genome Ed2026https://conductscience.org/library/papers/42840083PubMed
42,793,032Prime Editing for Precision Genetic Medicine: A Systematic Review of Technologies, Delivery, and Therapeutic Applications.Genes (Basel)2026https://conductscience.org/library/papers/42793032PubMed
42,680,881Solute carrier membrane transporters: emerging targets in CNS disorders.Nat Rev Drug Discov2026https://conductscience.org/library/papers/42680881PubMed
42,666,729Cardiac involvement in Wilson disease: pathophysiology, clinical spectrum, and multimodality imaging assessment.Front Cardiovasc Med2026https://conductscience.org/library/papers/42666729PubMed
42,662,231Advances in prime editing: Molecular innovations, Large-fragment engineering, and AI-driven design.Biodes Res2026https://conductscience.org/library/papers/42662231PubMed
42,610,144AI-driven CRISPR strategies in breast cancer: Organoid modeling, adaptive editing, and precision delivery.Iran J Basic Med Sci2026https://conductscience.org/library/papers/42610144PubMed
42,599,088Liver Organoids: From Disease Modelling to Regenerative Medicine.Cell Prolif2026https://conductscience.org/library/papers/42599088PubMed
42,587,136Mechanistic machine learning for prediction of prime editing outcomes.Nat Biotechnol2026https://conductscience.org/library/papers/42587136PubMed
42,351,663Organoids in Pediatric Congenital Hepatobiliary Diseases: Current Status and Progress in Clinical Translational Research.Biomedicines2026https://conductscience.org/library/papers/42351663PubMed

1 to 10 of 143

See all 143 cited by

Genes10

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ACTB60PubTator's text mininghttps://conductscience.org/library/genes/60NCBI Gene
ATP7B540PubTator's text mininghttps://conductscience.org/library/genes/540NCBI Gene
BTRC8,945PubTator's text mininghttps://conductscience.org/library/genes/8945NCBI Gene
CTNNB11,499PubTator's text mininghttps://conductscience.org/library/genes/1499NCBI Gene
DGAT18,694PubTator's text mininghttps://conductscience.org/library/genes/8694NCBI Gene
DNASE11,773PubTator's text mininghttps://conductscience.org/library/genes/1773NCBI Gene
EPHA82,046PubTator's text mininghttps://conductscience.org/library/genes/2046NCBI Gene
ERF2,077PubTator's text mininghttps://conductscience.org/library/genes/2077NCBI Gene
NEB4,703PubTator's text mininghttps://conductscience.org/library/genes/4703NCBI Gene
RSPO1284,654PubTator's text mininghttps://conductscience.org/library/genes/284654NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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